Activités de recherche du CNR des Corynebactéries du complexe diphtheriae

Effectuée en s’appuyant sur les données et sur le matériel biologique recueillis dans le cadre du CNR, l’activité de recherche est décrite dans le rapport annuel d’activité. Elle est complémentaire de l'activité de recherche de l'unité Biodiversité et épidémiologie des bactéries pathogènes à laquelle le CNR est rattaché.

Publications principales

Diphtheria Outbreak among Migrants in Europe.
Reply Hoefer A, Brisse S. N Engl J Med. 2025 Oct 9;393(14):1445.
doi: 10.1056/NEJMc2510099. PMID: 41061243.

Corynebacterium diphtheriae Outbreak in Migrant Populations in Europe
Hoefer A, Seth-Smith H, Palma F, Schindler S, Freschi L, Dangel A, Berger A, D'Aeth J, Cordery R, Delgado-Rodriguez E, Gruner E, Flury D, Hinic V, Kofler J, Lienhard R, Mariman R, Nolte O, Schibli A, Toubiana J, Traugott M, Jacquinet S, Indra A, Fry NK, Palm D, Sing A, Brisse S, Egli A; 2022. N Engl J Med. 2025 Jun 19;392(23):2334-2345. doi: 10.1056/NEJMoa2311981. Epub 2025 Jun 4. PMID: 40466062.

Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing 
Zidane N, Rodrigues C, Bouchez V, Rethoret-Pasty M, Passet V, Brisse S, Crestani C. Genome Res. 2025 Aug 1;35(8):1758-1766. doi: 10.1101/gr.279829.124. PMID: 40456603; PMCID: PMC12315706.

Microevolution and genomic epidemiology of the diphtheria-causing zoonotic pathogen Corynebacterium ulcerans
Crestani C, Passet V, Rethoret-Pasty M, Zidane N, Brémont S, Badell E, Criscuolo A, Brisse S. Nat Commun. 2025 May 24;16(1):4843. doi: 10.1038/s41467-025-60065-0. PMID: 40413184; PMCID: PMC12103533.

Diphtheria antitoxin treatment: from pioneer to neglected
Grandière Pérez L, Brisse S. Mem Inst Oswaldo Cruz. 2025 Jan 20;120:e240214. doi: 10.1590/0074-02760240214. PMID: 39841756; PMCID: PMC11752783.

Cutaneous diphtheria from 2018 to 2022: an observational, retrospective study of epidemiological, microbiological, clinical, and therapeutic characteristics in metropolitan France
Chêne L, Morand JJ, Badell E, Toubiana J, Janvier F, Marthinet H, Suppini JP, Valois A, Texier G, Brisse S, Dutasta F ŒDIPE Study Group. Emerg Microbes Infect. 2024 Dec;13(1):2408324. doi: 10.1080/22221751.2024.2408324. Epub 2024 Sep 30. PMID: 39324172; PMCID: PMC11443539.

Retrospective Study of Infections with Corynebacterium diphtheriae Species
Complex, French Guiana, 2016-2021 Gaillet M, Hennart M, Rose VS, Badell E, Michaud C, Blaizot R, Demar M, Carvalho L, Carod JF, Andrieu A, Djossou F, Toubiana J, Epelboin L, Brisse S. Emerg Infect Dis. 2024 Aug;30(8):1545-1554. doi: 10.3201/eid3008.231671. PMID: 39043387; PMCID: PMC11286053.

Corynebacterium diphtheriae and Corynebacterium ulcerans: development of EUCAST methods and generation of data on which to determine breakpoints
Berger A*, Badell E*, Åhman J*, Matuschek E, Zidane N, Kahlmeter G, Sing A, Brisse S. J Antimicrob Chemother. 2024 Mar 18:dkae056. doi: 10.1093/jac/dkae056.

La diphtérie zoonotique à Corynebacterium ulcerans à l’interface des santés humaine et animale
Laaberki MH, Djelouadji Z, Ayral F, Bouchard M, Brisse S. Le Point Vétérinaire.vol 454, June 2024. Lien vers l’article complet : https://www.lepointveterinaire.fr/publications/le-point-veterinaire/article/n-454/la-diphtarie-zoonotique-a-corynebacterium-ulcerans-a-l-interface-des-santas-humaine-et-animale.html

A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence
Melanie Hennart, Chiara Crestani, Sebastien Bridel, Nathalie Armatys, Sylvie Brémont, Annick Carmi-Leroy, Annie Landier, Virginie Passet, Laure Fonteneau, Sophie Vaux, Julie Toubiana, Edgar Badell, Sylvain Brisse (2023), bioRxiv, ver.3, peer-reviewed and recommended by PCI Infections 

Corynebacterium ramonii sp. nov., a novel toxigenic member of the Corynebacterium diphtheriae species complex
Chiara Crestani  1 , Gabriele Arcari  2 , Annie Landier  3 , Virginie Passet  3 , Dorian Garnier  3 , Sylvie Brémont  4 , Nathalie Armatys  3 , Annick Carmi-Leroy  4 , Julie Toubiana  5 , Edgar Badell  4 , Sylvain Brisse  6 Res Microbiol 2023

Ongoing diphtheria outbreak in Yemen: a cross-sectional and genomic epidemiology study.
Edgar Badell, Abdulilah Alharazi, Alexis Criscuolo, The NCPHL diphtheria outbreak working group#, Khaled Abdullah Ali Almoayed, Noémie Lefrancq, Valerie Bouchez, Julien Guglielmini, Melanie Hennart, Annick Carmi-Leroy, Nora Zidane, Marine Pascal-Perrigault, Manon Lebreton, Helena Martini, Henrik Salje, Julie Toubiana, Fekri Dureab, Ghulam Dhabaan and Sylvain Brisse August 2021, Lancet Microbe, e386.

Genomic Epidemiology and Strain Taxonomy of Corynebacterium Diphtheriae.
Julien Guglielmini, Melanie Hennart, Edgar Badell, Julie Toubiana, Alexis Criscuolo, and Sylvain Brisse. J Clinical Microbiology 59, no. 12 (2021): e0158121.

Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries.
Berbers G, van Gageldonk P, Kassteele J van de, Wiedermann U, Desombere I, Dalby T, Toubiana J, Tsiodras S, Ferencz IP, Mullan K, Griskevicius A, Kolupajeva T, Vestrheim DF, Palminha P, Popovici O, Wehlin L, Kastrin T, Maďarová L, Campbell H, Ködmön C, Bacci S, Barkoff A-M, He Q, Serosurveillance Study Team. 2021. Nat Commun 12:2871.

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae.
Hennart M, Panunzi LG, Rodrigues C, Gaday Q, Baines SL, Barros-Pinkelnig M, Carmi-Leroy A, Dazas M, Wehenkel AM, Didelot X, Toubiana J, Badell E, Brisse S. Genome Med. 2020 Nov 27;12(1):107. doi: 10.1186/s13073-020-00805-7. PMID: 33246485

Corynebacterium rouxii sp. nov., a novel member of the diphtheriae species complex.
Badell E, Hennart M, Rodrigues C, Passet V, Dazas M, Panunzi L, Bouchez V, Carmi-Leroy A, Toubiana J, Brisse S. Res Microbiol. 2020 Apr-Jun;171(3-4):122-127. doi: 10.1016/j.resmic.2020.02.003. Epub 2020 Feb 28. PMID: 32119905

Taxonomic status of Corynebacterium diphtheriae biovar Belfanti and proposal of Corynebacterium belfantii sp. nov.
Dazas M, Badell E, Carmi-Leroy A, Criscuolo A, Brisse S. Int J Syst Evol Microbiol. 2018 Dec;68(12):3826-3831. doi: 10.1099/ijsem.0.003069. Epub 2018 Oct 24.

Improved quadruplex real-time PCR assay for the diagnosis of diphtheria.
Badell E, Guillot S, Tulliez M, Pascal M, Panunzi LG, Rose S, Litt D, Fry NK, Brisse S. J Med Microbiol. 2019 Oct;68(10):1455-1465. doi: 10.1099/jmm.0.001070. Epub 2019 Sep 3. PMID: 31478826

Carriage of a Single Strain of Nontoxigenic Corynebacterium diphtheriae bv. Belfanti (Corynebacterium belfantii) in Four Patients with Cystic Fibrosis.
Pivot D, Fanton A, Badell-Ocando E, Benouachkou M, Astruc K, Huet F, Amoureux L, Neuwirth C, Criscuolo A, Aho S, Toubiana J, Brisse S. J Clin Microbiol. 2019 Apr 26;57(5):e00042-19. doi: 10.1128/JCM.00042-19. Print 2019 May. PMID: 30814269

Diphtheria in Mayotte, 2007-2015.
Belchior E, Henry S, Badell E, Collet L, Benoit-Cattin T, de Montera AM, Guiso N, Patey O, Levy-Bruhl D, Filleul L, Chieze F, Olivier S. Emerg Infect Dis. 2017 Jul;23(7):1218-1220. doi: 10.3201/eid2307.170262. PMID: 28628446

Toxigenic Corynebacterium ulcerans in a fatal human case and her feline contacts, France, March 2014.
Vandentorren S, Guiso N, Badell E, Boisrenoult P, Micaelo M, Troché G, Lecouls P, Moquet MJ, Patey O, Belchior E. Euro Surveill. 2014 Sep 25;19(38):20910. doi: 10.2807/1560-7917.es2014.19.38.20910. PMID: 25306877

Microbiological changes and diversity in autochthonous non-toxigenic Corynebacterium diphtheriae isolated in France.
Farfour E, Badell E, Dinu S, Guillot S, Guiso N. Clin Microbiol Infect. 2013 Oct;19(10):980-7. doi: 10.1111/1469-0691.12103. Epub 2013 Jan 15. PMID: 23320433

Mis à jour le 01/12/2025