The 2017-2018 call for enrollment of students in October 2018 is open.
Candidates are advised to read carefully the Application information section for details on the application procedures.
The titles of PhD projects and the names of the laboratory heads and thesis directors are listed below. For each project, there is a direct link to a description of the project proposal with contact information. The first step is to apply to the thesis director of the project(s) of interest by sending a CV and a letter of motivation. You may apply to more than one project, however by November 2nd, each thesis director must choose just one candidate to present to the Admissions committee.
Laboratories may be contacted from now until November 2nd, the sooner the better. The full applications, prepared jointly by the candidate and the laboratory, are due November 13. Interviews of selected candidates will take place January 30 – February 2, 2018. Start of the Ph.D.: October 1st, 2018.
More information about the scientific interests of the Departments and Laboratories is available at www.pasteur.fr/en/research.
The list below may be updated regularly, with the most recent proposals appearing at the end.
|
Project number |
Title of the PhD project |
Lab name / Department |
Keywords |
Lab Head / Thesis Director |
|---|---|---|---|---|
|
The actinobacterial exception: structure and regulation of a central metabolic supercomplex |
Stuctural Microbiology Structural Biology & Chemistry |
Actinobacteria, tuberculosis, Corynebacterium, integrative structural biology,macromolecular complexes, metabolism, X-ray crystallography, cryo-EM |
Pedro Alzari Marco Bellinzoni
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Mechanism of regulation and functional conservation of IMPDH, a key enzyme of the guanine nucleotide metabolism |
Chemistry and Biocatalysis Structural Biology & Chemistry |
Invasive bacteria, nucleotide metabolism, IMPDH, supramolecular assembly, Bateman domain, effector binding site, enzymology, biophysics, structural biology, two-hybrid screening, interactome |
Sylvie Pochet Hélène Munier-Lehmann |
|
|
Membrane insertion and translocation of the CyaA toxin |
Biochemistry of Molecular Interactions Structural Biology & Chemistry |
Protein membrane interaction, protein membrane translocation, lipid |
Daniel Ladant Alexandre Chenal |
|
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Role of intermediate filaments in mechanotransduction during cell migration |
Cell polarity, Migration and Cancer Cellular Biology & Infection |
Migration, cytoskeleton, intermediate filaments, mechanotransduction, nuclear organization |
Sandrine Etienne-Manneville |
|
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Unraveling the molecular mechanism of type IIB topoisomerases
|
Structural microbiology Structural biology & chemistry |
Integrative structural biology, topoisomerase, new DNA topoisomerase, topoisomerase VI, topoisomerase VIII |
Pedro Alzari Claudine Mayer |
|
|
Interplay between polarity proteins, junction complexes and regulators of Rho-GTPases in the control of apical contraction during hematopoietic stem cell emergence from the aorta floor in the zebrafish embryo |
Macrophages and Development of Immunity Developmental & Stem Cell Biology |
Hematopoiesis, stem cells, zebra fish, live cell imaging, cell and developmental biology
|
Philippe Herbomel Anne Schmidt |
|
|
Control of bacterial cell shape |
Bacterial Morphogenesis and Growth Microbiology |
Regulation of bacterial growth and morphogenesis, peptidoglycan cell wall, high-resolution fluorescence microscopy, genetics of cell-shape regulation |
Sven van Teeffelen |
|
|
Unraveling the metacyclic to bloodstream form differentiation of African trypanosomes during the early infection of the Mammalian host |
Trypanosome Cell Biology Parasites & Insect Vectors |
African trypanosome, Tsetse flies, host, infection, metacyclic form, bloodstream form, virulence factor |
Philippe Bastin Brice Rotureau |
|
|
Modulation of the human T cell response by type I interferon |
Cytokine Signaling Immunology |
Human immunology, autoimmunity, inflammation, gene regulation |
Sandra Pellegrini Frédérique Michel |
|
|
Study of RNA molecules contained in extracellular vesicles in Cryptococcus neoformans |
RNA Biology of Fungal Pathogens Mycology |
RNA, Pathogenic fungi, vesicles, Cryptococcus neoformans |
Guilhem Janbon |
|
|
USF1 transcription factors and the oncogenic response to H. pylori infection |
Infection, Genotoxicity and cancer Microbiology |
H. pylori, host-pathogen interaction, gene regulation, DNA repair, oncogenesis, gastric cancer |
Hilde De Reuse Eliette Touati |
|
|
Synthetic carbohydrate-based conjugates toward a broad coverage vaccine against bacillary dysentery |
Chemistry of Biomolecules Structural Biology & Chemistry |
Chemical biology, Glycochemistry, Target synthesis, Molecular tools, Glycosylation, Protecting group manipulation, Bioconjugates, Carbohydrate-protein interactions, Antigens, Vaccines, Diarrheal diseases, Shigella |
Laurence Mulard |
|
|
The malaria parasite epitranscriptome: Deciphering the role of RNA modifications in malaria parasite virulence and development |
Biology of Host-Parasite Interactions Parasites & Insect Vectors |
Epitranscriptomics, translation control, non-coding RNA, RNA-protein interactions, CRISPR/Cas9 genome editing |
Artur Scherf |
|
|
Fetal liver hematopoiesis: characterization of the hematopoietic stromal compartment that sustains stem cell expansion |
Lymphopoiesis Immunology |
Fetal liver, stroma, hematopoiesis |
Ana Cumano |
|
|
Combatting Alzheimer´s Disease by Activating Autophagy |
Membrane Biochemistry and Transport Cell Biology & Infection |
Autophagy, initiation, ULK1 complex, ATG9, Alzheimer, neurodegeneration |
Thomas Wollert |
|
|
Structural and functional characterization of intact pestivirus non-structural membrane protein 2 (NS2) |
Structural Virology Virology |
Pestivirus, uncleaved NS2-NS3, membrane protein expression and purification, x-ray crystallography, single-particle cryo-electron microscopy (cryo-EM) |
Félix A. Rey M. Alejandra Tortorici
|
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Aberrant RNA detection and degradation through nonsense-mediated mRNA decay |
Genetics of Macromolecular Interactions Genomes & Genetics |
RNA degradation, RNA translation, yeast, nonsense-mediated mRNA decay |
Alain Jacquier Cosmin Saveanu
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Investigation of the role of neuronal, microglial and glial cells during rabies virus infection in the modulation of the innate immune response
|
Lyssavirus Dynamics and Host Adaptation Infection & Epidemiology |
Brain, rabies, inflammation, neurons, glial cells, microglial cells |
Hervé Bourhy |
|
|
The role of nicotinic receptors in Alzheimer’s Disease pathology and treatment
|
Integrative Neurobiology of Cholinergic Systems Neuroscience |
Alzheimer’s Disease, nicotinic receptor, mouse models, in vivo imaging |
Uwe Maskos |
|
|
Functional study of the TIFA-dependent innate immune response during Chlamydia trachomatis infection |
Cellular Biology of Microbial Infection Cell Biology & Infection |
Innate defense, signaling cascade, female genital tract, Chlamydia trachomatis, bacterial infection |
Agathe Subtil Yongzheng Wu |
|
|
Study of the interplay between nucleoporins and chromatin factors to orchestrate HIV-1 replication |
Molecular Virology and Vaccinology Virology |
HIV-1, ChIP-sequencing, mass spectrometry, super-resolution microscopy, nuclear pore complex, chromatin |
Pierre Charneau Francesca Di Nunzio |
|
|
Left-right patterning of heart morphogenesis |
Heart Morphogenesis Developmental & Stem Cell Biology |
Left-right patterning, asymmetric morphogenesis, congenital heart defects, mouse genetics, transcriptomics
|
Sigolène Meilhac |
|
|
Generation and Identity of long-lived B cell Plasmocytes |
Antibodies in Therapy & Pathology Immunology |
Plasmocytes, B cell memory, autoimmune diseases, rituximab treatment |
Pierre Bruhns François Huetz |
|
|
New tool for visualizing and detecting Klebsiella pneumoniae infections |
Photonic BioImaging Center for Innovation and Technological Research & Cell Biology and Infection |
Aptamer, nanobody, Klebsiella pneumoniae, in vivo imaging |
Spencer Shorte Régis Tournebize |
|
|
Human infection with zoonotic simian foamy retroviruses: role of virological and immunological factors in restricting viral emergence |
Epidemiology and Physiopathology of oncogenic viruses Virology |
Retroviruses, zoonosis, emergence, neutralizing antibodies |
Antoine Gessain Florence Buseyne |
|
|
Effect of T cell immunity on antibody-dependent enhancement phenomenon in dengue viral infection |
Functional Genetics of Infectious Diseases Genome & Genetics |
Dengue virus, dengue vaccine, T cell immunity, antibody-dependent enhancement, ADE, endothelial cells dysfunction |
Anavaj Sakuntabhai |
|
|
Zika virus replication and antiviral responses |
Virus and Immunity Virology |
Zika, virus, restriction factors, cytopathic effect, cell death |
Olivier Schwartz |
|
|
How can Yersinia pestis become invisible to the host immune system? |
Yersinia Research Microbiology |
Plague, Yersinia pestis, host cellular immune response, immune evasion |
Javier Pizarro Cerda Christian Demeure |
|
|
Control of fatty acid degradation in enterobacteria |
Metabolism and Stress Adaptation Microbiology |
Stress response, genetic regulation, metabolism, fatty acid, E. coli, Salmonella |
Frédéric Barras Emmanuelle Bouveret
|
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|
Roles of cellular interactions within neural stem cell lineages during niche morphogenesis and lineage progression |
Brain plasticity in response to the environment Developmental & Stem Cell Biology |
Neural stem cells, lineage, niche, glia, communication, morphogenesis, Drosophila
|
Pauline Spéder-Murphy |
|
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Molecular evolution and viral adaptability in different host environments
|
Functional Genetics of Infectious Diseases Genomes & Genetcs |
Virus, evolution, human genetics |
Anavaj Sakuntabhai Etienne Simon-Loriere / Jean-François Bureau |
|
|
Genomic portrait of a neonatal pathogen |
Biology of Gram-positive Pathogens Microbiology |
Streptococcus agalactiae, Tn-Seq, essential genes, metabolism, host-pathogen interaction |
Patrick Trieu-Cuot Arnaud Firon |
|
|
Deciphering the interactome of bacterial pathogens with mass spectrometry
|
Utechs Mass Spectrometry for Biology Structural Biology & Chemistry |
Mass Spectrometry, top-down proteomic, cross-linking, native Mass spectrometry |
Julia Chamot-Rooke |
|
|
Molecular modeling of PTM alteration of Rac1 structure/function by environmental infectious and oncogenic factors |
Structural Bioinformatics Structural Biology & Chemistry |
Molecular modeling, enhanced sampling approaches, bacterial protein toxins, Rho GTPases, short linear motifs |
Michael Nilges Thérèse Malliavin |
|
|
The role of calcium in biogenesis and function of extra-cytoplasmic proteins in Gram-negative bacteria |
Biochemistry of Macromolecular Interactions Structural Biology & chemistry |
Protein folding, calcium, disulfide bonds, protein export, type 2 secretion |
Daniel Ladant Olivera Francetic |
|
|
Structural Dynamics of Macromolecular Complexes |
Structural Bioinformatics Structural Biology & Chemistry |
Mass Spectrometry, electron microscopy, computer modeling, macromolecular complexes.
|
Michael Nilges Ricardo Pellarin |
|
|
Deciphering the functional role of adult-born neuron integration and its effect on established networks |
Perception and Memory Neuroscience |
Adult neurogenesis, sensory systems, olfactory bulb, structural plasticity, computational modeling |
Pierre-Marie Lledo |
|
|
Identifying factors that affect the interplay between M. tuberculosis and human macrophages |
Integrated Mycobacterial Pathogenomics Genomes & Genetics |
Tuberculosis, innate immunity, host-pathogen interactions, macrophage |
Roland Brosch Ludovic Tailleux |
|
|
Super-resolution imaging and computational modeling of dynamic chromosome architecture
|
Imaging and Modeling Cell biology & infections |
Chromatin, polymers, simulations, super-resolution microscopy, nuclear architecture, DNA damage, gene expression
|
Christophe Zimmer |
|
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Dissecting the kinetics of long-distance enhancer-promoter interactions
|
Physics of biological function Developmental & stem cell biology |
Quantitative biology, live imaging, transcription, stem cells, embyros |
Thomas Gregor |
|
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Two-photon Imaging of large-scale functional connectivity during multimodal sensory integration
|
Neural circuit dynamics and decision making Neuroscience
|
Two-photon imaging, multi-sensory integration, behaviour, neocortex
|
Florent Haiss |