COVID-19 News

Here are the news, press releases and videos from the Institut Pasteur (Paris), which was mobilized as soon as the first cases were announced, following the declaration of the epidemic by the Chinese authorities. For the record, an epidemic of pneumonia of viral appearance and of unknown etiology emerged in the city of Wuhan (Hubei province, China) in December 2019. On January 9, 2020, the discovery of a new coronavirus (first called 2019-nCoV, then SARS-CoV-2) was officially announced by the Chinese health authorities and the World Health Organization (WHO). This coronavirus is the agent responsible for the new infectious respiratory disease called Covid-19 (CoronaVIrus Disease 2019).
Covid-19 Essai Clinique
2021.01.25
COVID-19: progress update on the Institut Pasteur's scientific response and vaccine candidate research programs
Since early 2020, the Institut Pasteur has been engaged in research in several of its areas of scientific expertise, including virology, diagnostics, pathophysiology, epidemiology, modeling, therapeutic research and vaccine research. A number of research programs to find a vaccine for SARS-CoV-2, the virus responsible for the COVID-19 epidemic, are under way. In light of the intermediate results of its Phase I clinical trial, the Institut Pasteur is stopping development of one of its vaccine candidates, the vaccine based on the measles vaccine virus.
COVID-19 : un projet vaccin lentiviral par voie intra-nasale assure une protection importante chez l’animal
2021.01.19
COVID-19: a lentiviral vaccine candidate for intranasal administration provides sterilizing protection in animal models
Scientists from the Institut Pasteur-TheraVectys Joint Laboratory recently published in Cell Host & Microbe1 the results of tests, in two preclinical models, of a COVID-19 vaccine candidate using a lentiviral vector administered by nasal route. Their study demonstrates that the vaccine candidate induces antibody response with strong neutralizing activity against SARS-CoV-2, as well as substantial cell-mediated responses.
2020.12.28
COVID-19: optimizing surveillance in long-term care facilities
Throughout the world, long-term care facilities have been high-risk sites for virus spread since the emergence of the COVID-19 epidemic. In this context, the capacity for timely surveillance and control of case numbers is essential in such facilities. Scientists at the Institut Pasteur have joined forces with the University of Versailles-Saint-Quentin-en-Yvelines, Inserm, and the National Conservatory of Arts and Trades to analyze various methods for surveillance and testing of residents at these facilities.
INNOVATION - Our Sucess Stories - Institut Pasteur
2020.12.07
Unprecedented solidarity and support to accompany the member institutes of the International Network in the face of the COVID-19 pandemic
The Institut Pasteur International Network, with the support of the International Department of the Institut Pasteur (Paris) and in association with institutional funders, has mobilised to help certain member institutes in Africa and Asia to carry out their public health missions in the context of the management of the COVID-19 pandemic.  The objective of this aid was to provide them with financial and logistical support to strengthen their surveillance, diagnosis and response systems in the face of the virus.
Covid-19 : la durée de la réponse immunitaire neutralisante plus longue chez les femmes que chez les hommes
2020.11.19
COVID-19: neutralizing immune response lasts longer in women than in men
As part of the SEROCoV-HUS study, teams from Strasbourg University Hospital and the Institut Pasteur monitored 308 hospital staff who had previously contracted a mild form of SARS-CoV-2. The scientists demonstrated that neutralizing antibodies could be detected in 84% of them up to 6 months after infection, but that the level fell more quickly in men than in women. These results seem to suggest that immunity lasts longer in women than in men.
2020.11.16
Operation and reliability of RT-PCR tests in the detection of SARS-CoV-2
The National Reference Center (CNR) for Respiratory Viruses at the Institut Pasteur specializes in viruses such as influenza and bronchiolitis in infants. As an expert center in France, the CNR is responsible for monitoring cases of respiratory infections and for epidemic surveillance. When a new virus emerges, like the novel coronavirus in China, the CNR's task is to do everything it can to detect the novel pathogen.
Nombre de décès de Covid-19 chez les moins de 65 ans : un indicateur plus fiable pour évaluer les taux d’infection dans les populations
2020.11.03
Number of Covid-19 deaths in the under-65s: a more reliable indicator for assessing infection rates in populations
Simply comparing the total number of deaths across countries may provide a misleading representation of the underlying level of transmission of SARS-CoV-2, the virus that causes COVID-19, because of large differences in reported COVID-19 death rates in elderly populations in different countries.
Fake News - Institut Pasteur
2020.11.04
COVID-19: Senlis Criminal Court convicts the author of a fake news video for defamation
On November 2, 2020, Senlis Criminal Court convicted the author of a misleading video claiming that the Institut Pasteur invented COVID-19, posted online on March 17, 2020, of public defamation towards the Institut Pasteur. The author's words, which were untrue and unfounded and were based on a misinterpretation of a patent submitted in 2004, led to a wave of strong reactions against the Institut Pasteur. Some members of staff and even some of their families were the victims of hateful messages, phone calls and/or emails, insults and threats.
Une équipe internationale de chercheurs a identifié des vulnérabilités communes aux coronavirus SARS-CoV-2, SARS-CoV-1 et MERS-CoV
2020.10.16
TEAM OF INTERNATIONAL SCIENTISTS IDENTIFY COMMON VULNERABILITIES ACROSS SARS-CoV-2, SARS-CoV-1 AND MERS CORONAVIRUSES
Driven by Molecular Insights, Massive Analysis of Medical Records from ~740,000 SARS-CoV-2 Patients Reveal Treatment Regimens for Current, and Potential Future, Viral Pandemics. Published on October 15, 2020, in Science. 
podcast - Institut Pasteur
2020.10.11
A sentinel for health monitoring #podcast
For the 2020 Pasteurdon (the Institut Pasteur’s public fundraising campaign), listen to a podcast in French. Mathieu Vidard, presenter of "La Terre au carré" on France Inter (major French public radio channel and part of Radio France), discusses with two distinguished scientists from the Institut Pasteur: Christophe d’Enfert, scientific director and François-Xavier Weill, who is in charge of a research unit that includes two national reference center. Both explain the Institut Pasteur's role in monitoring the occurrence of epidemics and in health surveillance.
podcast - Institut Pasteur
2020.10.07
Emerging diseases and Covid-19 #Podcast
Institut Pasteur's expertise in infectious diseases has made it one of the major players in research against Covid-19. For the 2020 Pasteurdon (the Institut Pasteur’s public fundraising campaign), a podcast in French has been recorded. Two Pasteurian researchers, Sylvie van der Werf and Arnaud Fontanet, talk about this pandemic and the Institut Pasteur's actions to fight the virus. They also explain how infectious diseases work and the factors behind the emergence of new diseases.    
Youtube Live - Institut Pasteur
2020.10.12
A feedback on 10 months of mobilization of the Institut Pasteur against covid-19
On Thursday, October 8, 2020, the Institut Pasteur in Paris organized an exceptional digital conference to review 10 months of mobilization against Covid-19, a force still in action for global health. Four experts from the Institut Pasteur were present to talk about the epidemic, tests, treatments, vaccines, scientific modelling, and answer questions from Internet users. This conference is available (in French) on the Youtube channel of the Institut Pasteur.  
2020.09.10
Editorial: How can we reach a level of herd immunity that will protect us from COVID-19?
Epidemiological theory teaches us that a microbial agent introduced into a population stops circulating when the proportion of the population that is immune to that agent is higher than or equal to 1-1/R0, where R0 is the much-discussed reproduction rate, the number of secondary cases generated by each infected person in a non-immune population in the absence of control measures.
2020.10.15
Innate immunity and fusion of cells infected with SARS-CoV-2
Innate immunity is the fastest-acting component of the immune system, but so far little is known about its role during infection with SARS-CoV-2. A few hours after an infection, the body emits an alarm signal, interferon, enabling cells that have not yet been infected to produce antiviral proteins. This phenomenon occurs well before the production of neutralizing antibodies. Scientists from the Institut Pasteur and the CNRS set out to investigate the consequences of SARS-CoV-2 infection for cell function and the antiviral role of innate immunity.
COVID-19 : un projet vaccin lentiviral par voie intra-nasale assure une protection importante chez l’animal
2021.01.19
COVID-19: a lentiviral vaccine candidate for intranasal administration provides sterilizing protection in animal models
Scientists from the Institut Pasteur-TheraVectys Joint Laboratory recently published in Cell Host & Microbe1 the results of tests, in two preclinical models, of a COVID-19 vaccine candidate using a lentiviral vector administered by nasal route. Their study demonstrates that the vaccine candidate induces antibody response with strong neutralizing activity against SARS-CoV-2, as well as substantial cell-mediated responses.
2020.07.15
Type 1 Interferon deficiency: A blood based Signature for Detecting Patients at risk of severe Covid-19 for a therapeutic approach
Which patients will develop a severe form of Covid-19? This is a key question that needs to be answered to improve the individual management and prognosis of patients. In a study published in Science on July 13, teams from AP-HP, Inserm, Université of Paris, Institut Pasteur and Institut Imagine describe a unique and unexpected immunological phenotype in severe and critical patients, consisting of a severely impaired response of interferon (IFN) type I, associated with a persistent blood viral load and an excessive inflammatory response.
2020.07.15
Type 1 Interferon deficiency: A blood based Signature for Detecting Patients at risk of severe Covid-19 for a therapeutic approach
Which patients will develop a severe form of Covid-19? This is a key question that needs to be answered to improve the individual management and prognosis of patients. In a study published in Science on July 13, teams from AP-HP, Inserm, Université of Paris, Institut Pasteur and Institut Imagine describe a unique and unexpected immunological phenotype in severe and critical patients, consisting of a severely impaired response of interferon (IFN) type I, associated with a persistent blood viral load and an excessive inflammatory response.
2020.07.06
COVID-19: no cross-protective immunity conferred by other coronaviruses in children
Every winter, seasonal coronaviruses are responsible for repeated colds and bronchitis from early childhood onwards. The question of whether the four seasonal coronaviruses can confer cross-protective immunity for COVID-19 was recently raised when it was demonstrated that some individuals had antibodies and immunity cells recognizing the SARS-CoV-2 virus before it was in active circulation. The existence of such immunity would have a major impact on our understanding of how the outbreak is likely to develop.
Covid-19 dans les écoles primaires : pas de transmission importante du virus entre enfants ou vers les enseignants
2020.06.23
COVID-19 in primary schools: no significant transmission among children or from students to teachers
In late April 2020, scientists at the Institut Pasteur, with the support of the Hauts-de-France Regional Health Agency and the Amiens Education Authority, carried out an epidemiological survey on 1,340 people linked to primary schools in Crépy-en-Valois, in the Oise department. Thanks to the cooperation of the people of Crépy-en-Valois, the survey, which made use of serological tests developed by the Institut Pasteur, revealed that the proportion of primary school students infected by the novel coronavirus was 8.8%.
2020.07.06
COVID-19: no cross-protective immunity conferred by other coronaviruses in children
Every winter, seasonal coronaviruses are responsible for repeated colds and bronchitis from early childhood onwards. The question of whether the four seasonal coronaviruses can confer cross-protective immunity for COVID-19 was recently raised when it was demonstrated that some individuals had antibodies and immunity cells recognizing the SARS-CoV-2 virus before it was in active circulation. The existence of such immunity would have a major impact on our understanding of how the outbreak is likely to develop.
Coronavirus - SARS-CoV - SRAS - Institut Pasteur
2020.01.22
SARS-CoV-2 : le rôle de l’Institut Pasteur dans la surveillance du virus 2019 n-CoV apparu en Chine (in French)
Dans le cadre de sa mission de surveillance des virus respiratoires sur le territoire français, l’Institut Pasteur mobilise ses équipes, notamment via le centre national de référence (CNR) des virus des infections respiratoires. Son rôle est d’identifier et confirmer les suspicions d’infection respiratoires aiguës liées au nouveau coronavirus apparu à Wuhan, en Chine, en décembre 2019, et dont le bilan s’alourdit chaque jour en ce début d’année.
Arnaud Fontanet Institut Pasteur
2020.07.02
Tête à Tête avec Arnaud Fontanet : la transmission de la Covid-19 dans les écoles primaires (In French)
Transmission de la COVID-19 dans les écoles primaires - Institut Pasteur
2020.06.24
Transmission de la COVID-19 dans les écoles primaires (in French)
Coronavirus 2019-nCoV : dernières avancées virologiques et présentation de la Task Force - Institut Pasteur
2020.06.18
Coronavirus 2019-nCoV : dernières avancées virologiques et présentation de la Task Force (in French)
Coronavirus - En temps de pandémie, la recherche fait partie de la réponse
2020.03.13
Coronavirus - En temps de pandémie, la recherche fait partie de la réponse Coronavirus: Institut Pasteur warns against false information circulating on social media (in French)
Lors de son allocution à la Nation, le Président de la République Française a rappelé sa « confiance dans la science » face à la pandémie de Covid-19.  Depuis les tous premiers cas de Covid-19 sur le sol français, la recherche française se mobilise pour comprendre le virus et tenter d’en limiter sa propagation. Les laboratoires de l’Institut Pasteur, de l’Inserm, du CNRS, et de leurs partenaires universitaires, unissent leurs connaissances et partagent leurs travaux. 
Une étude préclinique montre que l’hydroxychloroquine n’a pas d’effet antiviral contre le SARS-CoV-2 in vivo
2020.05.29
A preclinical study shows that hydroxychloroquine has no antiviral effect on SARS-CoV-2 in vivo
A study on the effects of hydroxychloroquine n macaques infected with the SARS-CoV-2 virus, used alone or in combination with azithromycin, have been pre-published(1) on Research Square, after their submission to Nature. Scientists from the CEA, Inserm, Institut Pasteur, Université de Paris-Saclay, Université Claude Bernard Lyon 1 and Aix-Marseille Université have been involved in the study, which has been carried out under the aegis of the multidisciplinary consortium, REACTing(2).
2020.04.17
L’Institut Pasteur étudie la transmission du SARS-CoV-2 de l’Homme aux animaux domestiques (in French)
L'infection par le SARS-CoV-2 présente des défis sans précédent liés au contrôle et à la prévention de cette maladie virale dans le monde. Si l’émergence du virus est bien documentée, d'importantes questions sur la transmissibilité de la maladie restent sans réponse, en particulier concernant les animaux de compagnie.
Laboratoire Réponse Humorale aux Pathogènes
2020.04.15
Vers des anticorps thérapeutiques contre le Covid-19 (in French)
Le laboratoire Immunologie humorale de l’Institut Pasteur (équipe Inserm/Pasteur dirigée par Hugo Mouquet) recherche des anticorps capables de neutraliser le virus SARS-Cov-2. Dans ce but, l’équipe d'Hugo Mouquet va isoler des lymphocytes B mémoires spécifiques du virus à partir du sang de patients en rémission, puis les utiliser pour permettre la production d’anticorps monoclonaux qu’elle étudiera au cas par cas. L’équipe espère ainsi rapidement proposer des anticorps monoclonaux potentiellement thérapeutiques, et contribuer au développement d’un vaccin.
Collectif
2020.04.15
Qu'est-ce que l'immunité collective ? (in French)
Alors que l'épidémie de Covid-19 est actuellement en cours, il est important de faire un point sur l'immunité collective. Comment se cacule-t-elle ? A quoi sert-elle ? Voici quelques explications.
Social
2020.04.14
SocialCov : Lancement d’une grande enquête auprès des français sur leurs contacts pendant le confinement (in French)
Les mesures de confinement mises en place sont, d’un point de vue épidémiologiques, inédites. Dans ce contexte, et pour comprendre l’évolution de la transmission du SARS-Cov-2, il est nécessaire d’évaluer la manière dont nos contacts ont changé au sein de notre population. Ainsi, il sera possible de les introduire dans les modèles prédictifs.
Medicaments
2020.04.10
COVIDAXIS : un essai clinique de prévention du Covid-19 chez les soignants (in French)
Le CHU de Saint Etienne et l’Institut Pasteur débutent un essai clinique, COVIDAXIS, qui va évaluer plusieurs médicaments pour prévenir l’infection par le SARS-CoV-2 chez le personnel soignant. En effet ces derniers sont particulièrement exposés et de nombreux cas ont été décrits chez les personnels soignants. En l’absence de vaccin, il est important d’évaluer si certains médicaments disponibles peuvent prévenir l’infection.
Tous unis contre le virus - Institut Pasteur
2020.03.24
Tous unis contre le virus : La Fondation de France, l’AP-HP et l’Institut Pasteur unissent leur force (in French)
Au sein d’une alliance « tous unis contre le virus », la Fondation de France, l’AP-HP et l’Institut Pasteur ont décidé d’unir leur force et de mobiliser tout leur réseau. Face à l’ampleur des besoins, un appel à la solidarité est lancé pour soutenir les soignants, les chercheurs et aider les personnes les plus vulnérables. Les dons collectés seront destinés à venir en aide aux personnels soignants, en milieu hospitalier ou non, à financer des projets de recherche ainsi qu’à soutenir des acteurs de terrain et des associations qui œuvrent auprès des plus vulnérables. 
2020.03.20
Lancement du site internet maladiecoronavirus.fr (in French)
Vous pensez avoir été exposé au Coronavirus Covid-19 et avez des symptômes ? Le ministère des Solidarités et de la Santé a validé un algorithme co-développé par l’Institut Pasteur et l’APHP permettant d’orienter, via des outils numériques, les personnes pensant avoir été exposées au Coronavirus (Covid-19). Toutes les personnes concernées sont invitées à utiliser l’une des applications référencées ci-dessous pour prendre connaissance de la marche à suivre en cas de doute (appel médecin traitant, appel SAMU Centre 15 etc.) :
COVID-19 : 20 projets de recherche sélectionnés pour lutter contre l’épidémie - Institut Pasteur
2020.03.12
Covid-19: 20 research projects selected to fight the epidemic
At a time when the Sars-CoV-2 epidemic is continuing to spread, France is mobilizing to accelerate research into the virus and Covid-19 disease through REACTing – a consortium coordinated by Inserm. With the support of the Ministry of Solidarity and Health and the Ministry of Higher Education, Research and Innovation, the Scientific Advisory Board of REACTing has selected 20 scientific initiatives covering diverse fields, from mathematical modelling to disease prevention and treatment.
COVID-19 - Institut Pasteur
2020.04.03
Coronavirus SARS-CoV-2: A look back at three months of mobilisation against an emerging disease (COVID-19)
On December 31, 2019, the WHO China Country Office was informed of cases of pneumonia of unknown etiology (unknown cause) detected in Wuhan City, Hubei Province of China. It was the official beginning of an epidemic that would rapidly become worldwide. In January, a task force was put in place at the Institut Pasteur and research projects were quickly launched. Here is a look back at three intense months.
Science
2020.03.20
Editorial: Facing challenges with the novel coronavirus SARS-CoV-2 outbreak
On December 31, 2019, Chinese authorities reported a cluster of pneumonia cases in Wuhan, China, most of which included patients whoreported exposure to a seafood market selling live animals. Emergence of a new pathogenic zoonotic coronavirus (SARS-CoV-2) was suspected. How can we face the challenges with the novel coronavirus SARS-CoV-2 outbreak?
CEPI collaborates with the Institut Pasteur in a consortium to develop COVID-19 vaccine
2020.03.19
CEPI collaborates with the Institut Pasteur in a consortium to develop Covid-19 vaccine
Consortium to be led by the Institut Pasteur and will include Themis and the University of Pittsburgh. CEPI to provide initial US$4.9 million for consortium to develop a Covid-19 vaccine candidate based on measles-vector technology. Partnership becomes eighth Covid-19 vaccine development project that CEPI has signed since Jan 23, 2020  
Coronavirus : attention aux fausses informations circulant sur les réseaux sociaux - Institut Pasteur
2020.10.22
Coronavirus: Institut Pasteur warns against false information circulating on social media
As the Covid-19 outbreak continues to spread in France, multiple information are circulating on social media and messaging platforms. Some of these messages contain misleading information, and some are supposedly based on the expertise of scientists at the Institut Pasteur. The Institut Pasteur asks you not to take any notice of this information and not to pass it on. 
COVID-19 : What we have learnt as of 20 February 2020 - Institut Pasteur
2020.02.20
COVID-19 : What we have learnt as of 20 February 2020
Fiche Maladie - Coronavirus de Wuhan - Institut Pasteur
2020.02.26
Novel coronavirus: what we know about the Covid-19 disease
During the weekend of February 22-23, 2020, the epidemic situation evolved worldwide with the intensification of outbreaks in South Korea, Japan and Singapore, and the appearance of new outbreaks in Iran and Italy. In these countries, we are witnessing a community transmission with no identified link with cases imported from China. This situation raises many questions. How is the disease diagnosed? What is the period of contagiousness? How long is the incubation? Etc. Here are the answers of the Institut Pasteur.  
2020.02.18
The Chinese Ambassador to France visits the Institut Pasteur
On Friday February 14, 2020, Stewart Cole, President of the Institut Pasteur, played host to His Excellency Mr Lu Shaye, Chinese Ambassador to France, who was visiting the Institut Pasteur to show support both personally and on behalf of his country for the Institut Pasteur’s efforts in response to the novel coronavirus outbreak.
Coronavirus - Wuhan - 2019-nCoV - Institut Pasteur
2020.01.31
Institut Pasteur isolates strains of coronavirus 2019-nCoV detected in France
As well as sequencing the whole genome of coronavirus 2019-nCoV, the Institut Pasteur continued to work on the samples taken from the first confirmed cases. The quality of these initial samples enabled rapid cell-culture isolation of the new virus. The Institut Pasteur's scientists now have access to the virus responsible for the infection. The isolation of the virus paves the way for new diagnostic, therapeutic and prophylactic approaches.
Coronavirus - Wuhan - 2019-nCoV - Institut Pasteur
2020.01.30
Institut Pasteur sequences the whole genome of the coronavirus, 2019-nCoV
On January 24, 2020, the French Ministry of Health confirmed the first three cases of patients affected by coronavirus, 2019-nCoV. On January 29, 2020, the Institut Pasteur, which is responsible for monitoring respiratory viruses in France, sequenced the whole genome of the coronavirus known as "2019-nCoV", becoming the first institution in Europe to sequence the virus since the start of the outbreak.
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