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News | 2020.07.09
Extravascular dermal trypanosomes in suspected and confirmed cases of Human African Trypanosomiasis
Diagnosis of sleeping sickness, a neglected tropical disease caused by African trypanosomes, relies on the detection of parasites in blood. Following their previous discovery that the skin is a reservoir for trypanosomes, scientists from the Institut Pasteur and colleagues have recently confirmed and quantified this phenomenon in humans, thereby improving our epidemiological understanding and...
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News | 2020.10.16
Deciphering Hantavirus’ structure
Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for which no treatment is available. X-ray structures of the hantavirus surface glycoprotein lattice reveal a built-in mechanism controlling envelope glycoprotein membrane insertion. This study provides important information for development of immunogen protection against these deadly viruses.Rodent-borne...
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Document de presse | 2021.05.11
Genetics: Biosynthesis pathway of a new DNA nucleobase elucidated
DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. This exception, the only one observed to date, has long remained a mystery. Scientists from the Institut Pasteur and the CNRS, in collaboration with the CEA, have now...
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News | 2021.05.06
New Edition of the Biobanking MOOC
(Free and Certifying)Biobanks are entities ensuring the governance, management and conservation of biological resources, living cells, viruses, bacteria and fungi, the genome of various organisms, etc….The objective of biobanks is to conserve these resources in the best possible conditions in order to maintain their integrity and to make them available both to the scientific community to advance...
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News | 2021.05.06
Creation of the startup SPIKIMM to develop monoclonal antibodies as an innovative treatment for Covid-19
The Institut Pasteur has recently signed an exclusive worldwide license agreement with the new biotech start-up SpikImm SAS, created by Truffle Capital, for the development of anti-SARS-CoV-2 (Covid-19) monoclonal antibodies for therapeutic and diagnostic use.Monoclonal antibody therapy is one of the most innovative ways currently available to treat Covid-19 patients and prevent severe forms of...
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Document de presse | 2021.05.07
Christine Petit co-recipient of the 2021 Gruber Neuroscience Prize
Since 1993 the Gruber Foundation honors and encourages educational excellence in the fields of Cosmology, Genetics, Neuroscience, Justice and Women’s Rights, recognizing groundbreaking work that provides new models that inspire and enable fundamental shifts in knowledge and culture.Established in 2004, the Neuroscience Prize honors scientists for major discoveries that have advanced the...
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Document de presse | 2021.05.05
COVID-19: discovery of the mechanisms of short- and long-term anosmia
Loss of smell, or anosmia, is one of the earliest and most commonly reported symptoms of COVID-19. But the mechanisms involved had yet to be clarified. Scientists from the Institut Pasteur, the CNRS, Inserm, Université de Paris and the Paris Public Hospital Network (AP-HP) determined the mechanisms involved in the loss of smell in patients infected with SARS-CoV-2 at different stages of the...
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Document de presse | 2021.05.12
An Asthma Vaccine Effective in Mice
Inserm teams led by Laurent Reber (Infinity, Toulouse) and Pierre Bruhns (Humoral Immunity, Institut Pasteur, Paris) and French company NEOVACS have developed a vaccine that could induce long-term protection against allergic asthma, reducing the severity of its symptoms and thus significantly improving patient quality of life. Their research in animals has been published in the journal Nature...
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Document de presse | 2021.05.21
ART Plus Combination Immunotherapy Expands Natural Killer Cells That Facilitate Control of HIV
Yerkes National Primate Research Center researchers in collaboration with Institut Pasteur have determined a combination immunotherapy of Interleukin-21 (IL-21) and interferon alpha (IFNa) is effective in generating highly functional natural killer (NK) cells that can help control and reduce simian immunodeficiency virus (SIV) in animal models. This finding is key for controlling HIV/AIDS, which...
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News | 2021.05.21
Mitochondrial diseases: a new screening leads to insight on the effect of various genes on DOA
Dominant optic atrophy (DOA) is one of the most common forms of mitochondrial disease. It can be caused by genetic mutations in OPA1 resulting in mitochondrial dysfunction. Researchers from Institut Pasteur and CNRS found ways to study and modulate the effect of genetic mutations in OPA1.Genetic mutations in the gene Optic Atrophy 1 (OPA1) cause a disease named Dominant optic atrophy (DOA). Most...
