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Document de presse | 2020.07.01
Microbiota: gut geography influences interactions between bacteria and their viruses
The gut microbiota houses a complex and varied microbial community that coexists in a balance which is crucial for human health but poorly understood. In this microbiota bacteria are under the predation by their viruses, bacteriophages, but some of them may find refuge in the mucus that covers gut tissue, thereby preserving the balance between populations of bacteriophages and bacteria. These are...
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Document de presse | 2021.04.21
SARS-CoV-2: infection induces antibodies capable of killing infected cells regardless of disease severity
Drawing on epidemiological field studies and the FrenchCOVID hospital cohort coordinated by Inserm, teams from the Institut Pasteur, the CNRS and the Vaccine Research Institute (VRI, Inserm/University Paris-Est Créteil) studied the antibodies induced in individuals with asymptomatic or symptomatic SARS-CoV-2 infection. The scientists demonstrated that infection induces polyfunctional antibodies....
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News | 2021.04.26
Yellow fever: understanding the rare side effects of vaccines
Preventive vaccination is a powerful tool in controlling viral outbreaks. It is important that any side effects associated with the use of vaccines are as mild as possible. Scientists from the Institut Pasteur set out to understand the reasons behind the rare neurological side effects that occasionally occur with use of the yellow fever vaccine. They studied a vaccine strain known as FNV, which...
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News | 2021.05.05
Malaria: Efficacy of a new treatment for Plasmodium vivax
Malaria remains a major public health burden in some world regions. In 2018, 237,000 cases were reported in Brazil, 91.5% of them caused by the parasite Plasmodium vivax. A new malaria drug known as tafenoquine was recently approved by several medicines regulatory authorities to treat P. vivax. Scientists from the Institut Pasteur, in partnership with the Oswaldo Cruz Foundation (Fiocruz) in...
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Fiche maladie | 2015.10.06
Group A and B Streptococcus
Infections with group A and B Streptococcus (respectively Streptococcus pyogenes and Streptococcus agalactiae) are frequent. The two bacteria are part of the commensal flora; they are opportunistic pathogens and only cause symptoms in certain conditions or in people at risk. Group A Streptococcus (also known as GAS or Strep A) is responsible for several benign infections but can also cause...
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News | 2020.02.04
Transgenerational sterility caused by heritable small RNAs
The results of a study from researchers from Institut Pasteur illustrate how small non-coding RNAs can act as epigenetic molecules capable of transmitting traits across generation, over and above the information encoded in our genomes. Using the nematode Caenorhabditis elegans they show that the inheritance of small RNAs antisense to histone genes adversely affect the fertility of worms across...
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News | 2021.04.29
AVATAR MEDICAL raises €1.2 million to equip surgeons and radiologists with virtual reality in France and the United States
AVATAR MEDICAL, a spin-off of Institut Pasteur and Institut Curie, has raised €1.2 million ($1.4 million) in pre-seed funding from investors including the Institut Pasteur to radically change the way surgeons access, interpret, and act upon the valuable clinical information contained in medical images.Founded in July 2020 by a team of French scientists and Franco-American entrepreneurs, AVATAR...
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News | 2021.04.30
Intraneural stem cells : How they are maintained at long-term
It remains unclear whether and how neural stem cells (NSCs) are maintained at long-term in the vertebrate brain. Combining intravital imaging, genetic tracing in vivo and biophysical modeling in the adult zebrafish, researches from Institut Pasteur quantitatively characterized NSC dynamics during adult life. The resulting model demonstrates that NSC maintenance is a population property,...
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News | 2020.07.03
ARIAweb: a server for automated NMR structure calculation
The ARIA software suite developed at Institut Pasteur automates the analysis of NMR data to calculate three-dimensional structures of macromolecules. To improve the user experience for ARIA and provide a larger and easier access, tructural bioinformatics Unit has created the ARIAweb server, providing an online service for such computationally intensive calculations and offering a dedicated...
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News | 2020.07.22
Modified aptamers allow recognition of malaria parasites
Aptamers can be thought of as analogs of antibodies entirely composed of nucleic acids (DNA or RNA). They can be used in a wide range of applications but they have limitations due to their inherent chemical nature. The Laboratory for Bioorganic Chemistry of Nucleic Acids demonstrated that chemically modified aptamers could distinguish P. vivax from P. falciparum, both...
