1. News | 2021.03.30

   Cancer: CAR T cell function scrutinized to improve immunotherapy

   Immunotherapy, or the notion of "retraining" patients' immune systems, constitutes a major step forward in the fight against cancer. Although the results of CAR T cell therapy are very positive, its efficacy is still difficult to predict. Research by scientists at the Institut Pasteur has improved our understanding of how these cells function. One immunotherapy strategy involves genetically...

2. Document de presse | 2021.04.06

   Light shed on the coordination of neural stem cell activation

   In all adult vertebrates, neural stem cells can be recruited to produce new neurons in the brain. However, little is known about these so-called "activation" processes. Scientists at the Institut Pasteur, CNRS, and Tel Aviv University working in collaboration with the École Polytechnique and INRAE have successfully performed 3D visualization and spatial and temporal distribution analysis of...

3. News | 2021.03.30

   Mobilization of the Institut Pasteur International Network to manage the COVID-19 outbreak: case study of support provided to the Institut Pasteur de Bangui

   Since the beginning of the COVID-19 pandemic, and increasingly rapidly thereafter, the Institut Pasteur International Network has drawn heavily on all its expertise and resources to tackle this emerging virus and its consequences, particularly through its support of institutes based in low-income countries. All Network member institutes have been identified by their health authorities as...

4. Document de presse | 2021.04.14

   Genetic admixture in the South Pacific: from Denisovans to the human immune response

   Describing the genetic diversity of human populations is essential to improve our understanding of human diseases and their geographical distribution. However, the vast majority of genetic studies have been focused on populations of European ancestry, which represent only 16% of the global population. Scientists at the Institut Pasteur, Collège de France, and CNRS have looked at understudied...

5. Document de presse | 2020.07.01

   Microbiota: gut geography influences interactions between bacteria and their viruses

   The gut microbiota houses a complex and varied microbial community that coexists in a balance which is crucial for human health but poorly understood. In this microbiota bacteria are under the predation by their viruses, bacteriophages, but some of them may find refuge in the mucus that covers gut tissue, thereby preserving the balance between populations of bacteriophages and bacteria. These are...

6. Document de presse | 2021.04.21

   SARS-CoV-2: infection induces antibodies capable of killing infected cells regardless of disease severity

   Drawing on epidemiological field studies and the FrenchCOVID hospital cohort coordinated by Inserm, teams from the Institut Pasteur, the CNRS and the Vaccine Research Institute (VRI, Inserm/University Paris-Est Créteil) studied the antibodies induced in individuals with asymptomatic or symptomatic SARS-CoV-2 infection. The scientists demonstrated that infection induces polyfunctional antibodies....

7. News | 2021.04.26

   Yellow fever: understanding the rare side effects of vaccines

   Preventive vaccination is a powerful tool in controlling viral outbreaks. It is important that any side effects associated with the use of vaccines are as mild as possible. Scientists from the Institut Pasteur set out to understand the reasons behind the rare neurological side effects that occasionally occur with use of the yellow fever vaccine. They studied a vaccine strain known as FNV, which...

8. News | 2021.05.05

   Malaria: Efficacy of a new treatment for Plasmodium vivax

   Malaria remains a major public health burden in some world regions. In 2018, 237,000 cases were reported in Brazil, 91.5% of them caused by the parasite Plasmodium vivax. A new malaria drug known as tafenoquine was recently approved by several medicines regulatory authorities to treat P. vivax. Scientists from the Institut Pasteur, in partnership with the Oswaldo Cruz Foundation (Fiocruz) in...

9. Fiche maladie | 2015.10.06

   Group A and B Streptococcus

   Infections with group A and B Streptococcus (respectively Streptococcus pyogenes and Streptococcus agalactiae) are frequent. The two bacteria are part of the commensal flora; they are opportunistic pathogens and only cause symptoms in certain conditions or in people at risk. Group A Streptococcus (also known as GAS or Strep A) is responsible for several benign infections but can also cause...

10. News | 2020.02.04

    Transgenerational sterility caused by heritable small RNAs

    The results of a study from researchers from Institut Pasteur illustrate how small non-coding RNAs can act as epigenetic molecules capable of transmitting traits across generation, over and above the information encoded in our genomes. Using the nematode Caenorhabditis elegans they show that the inheritance of small RNAs antisense to histone genes adversely affect the fertility of worms across...

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