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News | 2021.04.29
AVATAR MEDICAL raises €1.2 million to equip surgeons and radiologists with virtual reality in France and the United States
AVATAR MEDICAL, a spin-off of Institut Pasteur and Institut Curie, has raised €1.2 million ($1.4 million) in pre-seed funding from investors including the Institut Pasteur to radically change the way surgeons access, interpret, and act upon the valuable clinical information contained in medical images.Founded in July 2020 by a team of French scientists and Franco-American entrepreneurs, AVATAR...
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News | 2021.04.30
Intraneural stem cells : How they are maintained at long-term
It remains unclear whether and how neural stem cells (NSCs) are maintained at long-term in the vertebrate brain. Combining intravital imaging, genetic tracing in vivo and biophysical modeling in the adult zebrafish, researches from Institut Pasteur quantitatively characterized NSC dynamics during adult life. The resulting model demonstrates that NSC maintenance is a population property,...
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News | 2020.07.03
ARIAweb: a server for automated NMR structure calculation
The ARIA software suite developed at Institut Pasteur automates the analysis of NMR data to calculate three-dimensional structures of macromolecules. To improve the user experience for ARIA and provide a larger and easier access, tructural bioinformatics Unit has created the ARIAweb server, providing an online service for such computationally intensive calculations and offering a dedicated...
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News | 2020.07.22
Modified aptamers allow recognition of malaria parasites
Aptamers can be thought of as analogs of antibodies entirely composed of nucleic acids (DNA or RNA). They can be used in a wide range of applications but they have limitations due to their inherent chemical nature. The Laboratory for Bioorganic Chemistry of Nucleic Acids demonstrated that chemically modified aptamers could distinguish P. vivax from P. falciparum, both...
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News | 2020.03.27
The cooperativity mécanisms between DNA polymerase D and PCNA deciphered
Replicative DNA polymerases have evolved the ability to copy the genome with high processivity and fidelity. In Eukarya and Archaea, their processivity is greatly enhanced by binding to the proliferative cell nuclear antigen (PCNA) that encircles the DNA. By using an integrative approach which combines cryo-electron microscopy and X-ray crystallography, the Unit of Structural Dynamics...
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News | 2020.07.16
Gene therapy : Cas9 generates unexpected deletions
Triplet repeat expansions are responsible for more than two dozen neurological and developmental disorders. Shortening these repeats with endonucleases could become a viable option for patients affected with neurodegenerative disorders. Researchers from Institut Pasteur previously showed that a TALEN was very efficient for that use. They now show that Cas9 generates unexpected large chromosomal...
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News | 2020.03.05
The organization of mesenchymal stromal cells elucidated
Cells in vivo organize into 3D structures that underlie the shape and mechanics of tissues, as well as their biological function. Researchers mapped how mesenchymal stromal cells organize into organoids, by building a multiscale description based on massive single-cell data from microfluidic experiments. They found that cells organize into a core-shell structure that couples their level of...
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News | 2021.05.03
New Edition of the Emerging & Re-emerging Viruses MOOC
Free et Self-pacedEmerging and re-emerging viruses are key players among the different pathogens that have caused recent epidemics, as attested by several severe outbreaks affecting humans such as Ebola, chikungunya, influenza, Zika, dengue, SARS and MERS or outbreaks attacking animals such as rabies and bluetongue disease.This MOOC aims to provide a fundamental knowledge about the different...
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News | 2020.10.17
Cancer: Alternative NHEJ, a potential target
Ludovic Deriano’s Unit studied cells mutated for NHEJ, the canonical repair pathway for DNA double-strand break. The researchers showed that those transformed cells rely on alternative repair activities (alternative NHEJ) to survive DNA damage induced, in non-cycling (a state where the cell stops growing and dividing) G1 conditions. This alternative repair pathway represents an attractive target...
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News | 2021.02.22
How is the embryonic thymus microenvironment shaped ?
The Lymphopoiesis Unit identified within the first cells that seed the thymus a unique population of lymphoid progenitors. These cells can generate lymphoid tissue inducer or invariant T cells, two cell types that are critical in the immune system. They are required to ensure thymic medullary epithelial cell maturation and negative selection, at birth. These results highlight the relevance of a...
