1. News | 2020.10.17

   Cancer: Alternative NHEJ, a potential target

   Ludovic Deriano’s Unit studied cells mutated for NHEJ, the canonical repair pathway for DNA double-strand break. The researchers showed that those transformed cells rely on alternative repair activities (alternative NHEJ) to survive DNA damage induced, in non-cycling (a state where the cell stops growing and dividing) G1 conditions. This alternative repair pathway represents an attractive target...

2. News | 2021.02.22

   How is the embryonic thymus microenvironment shaped ?

   The Lymphopoiesis Unit identified within the first cells that seed the thymus a unique population of lymphoid progenitors. These cells can generate lymphoid tissue inducer or invariant T cells, two cell types that are critical in the immune system. They are required to ensure thymic medullary epithelial cell maturation and negative selection, at birth. These results highlight the relevance of a...

3. News | 2020.03.19

   Discovery of numerous potential open reading frames in the Cryptococcus genome

   Gene structure, including the transcript leader, is very diverse in fungi. New sequencing data analysis from the RNA Biology of Fungal Pathogens unit revealed that in the pathogenic yeasts Cryptococcus, the transcript leader sequence are rich in potential upstream Open Reading Frames, which regulate both gene expression and protein diversity.Pathogenic Cryptococcus species are responsible for...

4. News | 2020.10.24

   GABAA receptors undergo asymmetric motions

   α1β2γ2 GABAA receptors mediate most inhibitory synaptic transmission in the brain, and are the target of widely used therapeutic drugs such as benzodiazepines. Upon activation by the neurotransmitter, they undergo activation and desensitization transitions. Researchers from the Channel Receptors Unit showed that they undergo asymmetric motions during desensitization, with potential implications...

5. News | 2020.08.04

   Malaria: parasite resistance to artemisinin now found in Africa

   Resistance to artemisinin, the main component of current antimalarial treatments recommended by WHO, is widespread in South-East Asia, but has not been described in Africa. In a study published in 2020, scientists from the Institut Pasteur, in collaboration with the NMCP in Rwanda, the WHO and Columbia University provided for the first time evidence of the de novo emergence of Pfkelch13-mediated...

6. News | 2020.02.08

   Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium

   In nature, female mosquitoes take successive blood meals during which they are exposed to a variety of microbes present in the host. In Africa, Trypanosoma parasites, causing trypanosomiases, are sympatric with the malaria parasites. In recent work, we showed that pre-exposure of Anopheles mosquitoes to Trypanosoma enhances their vector competence to malaria parasites, reduces their reproductive...

7. News | 2020.07.09

   Extravascular dermal trypanosomes in suspected and confirmed cases of Human African Trypanosomiasis

   Diagnosis of sleeping sickness, a neglected tropical disease caused by African trypanosomes, relies on the detection of parasites in blood. Following their previous discovery that the skin is a reservoir for trypanosomes, scientists from the Institut Pasteur and colleagues have recently confirmed and quantified this phenomenon in humans, thereby improving our epidemiological understanding and...

8. News | 2020.10.16

   Deciphering Hantavirus’ structure

   Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for which no treatment is available. X-ray structures of the hantavirus surface glycoprotein lattice reveal a built-in mechanism controlling envelope glycoprotein membrane insertion. This study provides important information for development of immunogen protection against these deadly viruses.Rodent-borne...

9. Document de presse | 2021.05.11

   Genetics: Biosynthesis pathway of a new DNA nucleobase elucidated

   DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. This exception, the only one observed to date, has long remained a mystery. Scientists from the Institut Pasteur and the CNRS, in collaboration with the CEA, have now...

10. News | 2021.05.06

    New Edition of the Biobanking MOOC

    (Free and Certifying)Biobanks are entities ensuring the governance, management and conservation of biological resources, living cells, viruses, bacteria and fungi, the genome of various organisms, etc….The objective of biobanks is to conserve these resources in the best possible conditions in order to maintain their integrity and to make them available both to the scientific community to advance...

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