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News | 2021.01.26
Candida infections: the role of the Rme1 protein in the formation of chlamydospores
Candida albicans is a yeast that naturally resides in the human intestinal tract, but which can prove to be a formidable pathogen in the event of a drop in the host's immune defences, responsible for superficial or generalised ailments, sometimes fatal. A research group including researchers from the Institut Pasteur has studied the morphological mechanisms facilitating infection by C. albicans....
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News | 2021.02.01
COVID-19: New diagnostic tool for use outside the lab, offering the same efficacy as a PCR test
PCR tests are currently the gold standard for detecting SARS-CoV-2. These tests are reliable, but their complexity makes them difficult to use for point-of-care testing (POCT), in other words testing outside the laboratory. Scientists from the Institut Pasteur and ESPCI Paris-PSL have developed COVIDISC, a new portable device for this purpose. Since 2014, Institut Pasteur scientists have...
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News | 2021.02.05
COVID-19 risk factors surveillance among healthcare workers: a study implemented by MediLabSecure Project
According to the WHO recommendations, a multi-centre surveillance study has been implemented among healthcare workers in five African countries: Burkina Faso, Cameroon, Niger, Central African Republic and Madagascar. Coordinated by Institut Pasteur, this cohort study aims to identify the contamination risk factors and better understand the transmission/spread of the virus. The revue “...
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News | 2021.02.08
Antibiotic response in bacteria: the role of membrane vesicles
Membrane vesicles (also known as extracellular vesicles) are produced by all kinds of organisms. They are small lipid bags that come off a donor cell and get internalized by a recipient cell. Their role is to carry biological information and they are described as key intercellular communication players. However, their role in the microbial world is still very much unknown. Researchers from the...
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Fiche maladie | 2023.09.15
Legionellosis
Legionellosis is a collective term for diseases caused by Legionella bacteria, including the potentially fatal Legionnaires' disease. The most common species, Legionella pneumophila, causes a severe lung infection. The recent emergence of the disease can be explained by the affinity of Legionella bacteria for modern water supply systems. Although there is no vaccine for Legionnaires' disease, it...
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Document de presse | 2021.02.12
Heat islands and lack of running water promote dengue fever in Delhi, India
What if more inclusive urban planning for poor populations was key to fighting dengue fever? This is what researchers from the CNRS, the Institut Pasteur and the Indian Council of Medical Research1 have demonstrated using a geographical approach applied to the greater city of Delhi (India). Their study is published in the journal PLOS Neglected Tropical Disease on 11 February 2021. Dengue is a...
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Document de presse | 2021.02.12
Comment: The tortuous path to ending the Covid-19 pandemic
The COVID-19 pandemic has devastated health-care systems, shut down schools and communities, and plunged the world into an economic recession. While 2020 was a challenging year, 2021 looks to be difficult with the emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The race to vaccinate the world will need to respond to the pathogen's constant evolution...
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News | 2021.02.15
Discovery of messenger RNA in 1961
Since the beginning of the COVID-19 pandemic, words that just a year ago would have been the preserve of scientists have entered everyday language. One example is PCR, used for diagnostic tests. Another term that was once unfamiliar and is now on everyone's lips is messenger RNA, the miraculous molecule that has led to vaccines being administered to the general population less than a year after...
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News | 2021.03.09
Whooping cough: light shed on the entry mechanism of a key Bordetella pertussis virulence factor
Bordetella pertussis is the agent responsible for whooping cough, a disease that is currently on the rise. In particular, the bacterium produces the CyaA toxin. A consortium including several teams from the Institut Pasteur, CNRS, and Sorbonne University, working closely with the C2RT Proteins Pole technical cores and several SOLEIL and ESRF synchrotron light lines, has examined the entry...
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News | 2021.02.16
Quantitative biological image analysis and cell motility
Biological image analysis using mathematical methods, artificial intelligence and computer visualization techniques has become an essential tool for biological research and an effective driver for new discoveries. In a publication in Patterns (Cell Press)1, scientists from the "Bioimage Analysis Unit" recently presented the results of multidisciplinary research using quantitative image...
