Virus des infections respiratoires (dont la grippe)

Activités de recherche du CNR virus des infections respiratoires (dont la grippe)

  1. Virus des infections respiratoires (dont la grippe)
  2. Activités de recherche du CNR virus des infections respiratoires (dont la grippe)

Les travaux de recherche de l’unité de génétique moléculaire des virus à ARN en lien avec le CNR concernent :

  • l’étude des mécanismes de l’évolution génétique des virus influenza, par mutations et réassortiment, selon les types, sous-types et origines (humaine ou animale) des virus ; l’objectif est de mieux comprendre la dynamique de l’évolution des populations virales au cours de l’infection, en relation avec la sévérité clinique de l’infection et les traitements antiviraux.
  • l’étude des déterminants moléculaires de la transmission inter-espèces et de l’adaptation à un nouvel hôte des virus influenza A ;  outre une meilleure compréhension des modalités de multiplication des virus, l’identification des interactions entre le virus et les composants de la cellule hôte permettra de proposer de nouvelles cibles pour le développement de nouvelles approches thérapeutiques antivirales.

PUBLICATIONS 2010-2014 (CNR-IPP)

1.1.1Publications nationales

Mosnier A, Daviaud I, Vabret A, Valette M, Enouf V, Debost E, Cohen JM. Virus respiratoire syncytial : un impact non négligeable chez les seniors. Med Mal Infect. 2014 Jun;44(6 Suppl):51.

Equipes de surveillance de la grippe*, Belchior E. Surveillance épidémiologique et virologique de la grippe en France métropolitaine, saison 2013-2014. BEH 2014; 28 : 460-465.

Equipes de surveillance de la grippe*, Belchior E. Surveillance épidémiologique et virologique de la grippe en France métropolitaine, saison 2012-2013. BEH 2013; 32 : 394-401.

Equipes de surveillance de la grippe*, Belchior E. Surveillance épidémiologique et virologique de la grippe en France métropolitaine, saison 2011-2012. BEH 2012; 38 : 424-427.

Rousset D, Bouscambert-Duchamp M, Enouf V,Valette M, Grog I, Caro V, Van der Werf S, Lina B. (2010) Epidémie de grippe A(H1N1)2009 en France : les paramètres virologiques. BEH, 24-25-26, 22 juin 2010, 272-274

Vaux S, Brouard C, Fuhrman C, Turbelin C, Cohen JM, Valette M, Enouf V, Caillere N, George S, Fonteneau L, Gallay A, Nicolau J, Herida M, Gastellu-Etchegorry M, Mailles A, Belanger F, Cardoso T, Rousset D,Bouscambert-Duchamp M, Mosnier A, Pelat C, Chiron E, Levy-Bruhl D, Saura C. (2010) Dynamique et impact A(H1N1)2009 en France métropolitaine, 2009-2010. BEH, 24-25-26, 22 juin 2010, 259-266

1.1.2Publications internationales

Freidl GS, Meijer A, de Bruin E, de Nardi M, Munoz O, Capua I, Breed AC, Harris K, Hill A, Kosmider R, Banks J, von Dobschuetz S, Stark K, Wieland B, Stevens K, van der Werf S, Enouf V, van der Meulen K, Van Reeth K, Dauphin G, Koopmans M; FLURISK Consortium. Influenza at the animal-human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1). Euro Surveill. 2014 May 8;19(18). pii: 20793. Review.

Bonduelle O, Carrat F, Luyt CE, Leport C, Mosnier A, Benhabiles N, Krivine A, Rozenberg F, Yahia N, Samri A, Rousset D, van der Werf S, Autran B, Combadiere B. Characterization of pandemic influenza immune memory signature after vaccination or infection. J Clin Invest. 2014 Jul 1;124(7):3129-36. doi: 10.1172/JCI74565. Epub 2014 Jun 9

Guihot A, Luyt CE, Parrot A, Rousset D, Cavaillon JM, Boutolleau D, Fitting C, Pajanirassa P, Mallet A, Fartoukh M, Agut H, Musset L, Zoorob R, Kirilovksy A, Combadière B, van der Werf S, Autran B, Carcelain G; FluBAL Study Group. Low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection. Am J Respir Crit Care Med. 2014 May 15;189(10):1240-9.

Cauchemez S, Fraser C, Van Kerkhove MD, Donnelly CA, Riley S, Rambaut A, Enouf V, van der Werf S, Ferguson NM. Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility. Lancet Infect Dis. 2014 Jan;14(1):50-6.

Blanchon T, Mentré F, Charlois-Ou C, Dornic Q, Mosnier A, Bouscambert M, Carrat F, Duval X, Enouf V, Leport C; Bivir Study Group. Factors associated with clinical and virological response in patients treated with oseltamivir or zanamivir for influenza A during the 2008-2009 winter. Clin Microbiol Infect. 2013 Feb;19(2):196-203

Bonduelle O, Yahia N, Siberil S, Benhabiles N, Carrat F, Krivine A, Rozenberg F, Dimitrov J, Kaveri SV, Curjol A, Tindel M, Louet M, Desert F, Launay O, Loulergue P, Badre G, Katlama C, Bricaire F, Samri A, Rousset D, van der Werf S, Jauréguiberry S, Combadiere B.  Longitudinal and integrative biomodeling of effector and memory immune compartments after inactivated influenza vaccination.J Immunol. 2013 Jul 15;191(2):623-31.

Crescenzo-Chaigne B, Barbezange C, van der Werf S. The Panhandle formed by influenza A and C virus NS non-coding regions determines NS segment expression. PLoS One. 2013 Nov 21;8(11):e81550.

Desdouits M, Munier S, Prevost MC, Jeannin P, Butler-Browne G, Ozden S, Gessain A, Van Der Werf S, Naffakh N, Ceccaldi PE. Productive infection of human skeletal muscle cells by pandemic and seasonal influenza A(H1N1) viruses. PLoS One. 2013 Nov 5;8(11):e79628.

Durier C, Desaint C, Lucht F, Girard PM, Lévy Y, May T, Michelet C, Rami A, Roman F, Delfraissy JF, Aboulker JP, Launay O; ANRS 151 study group and the REIVAC network. Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults. AIDS. 2013 Jan 2;27(1):87-93.

Guery B, Poissy J, el Mansouf L, Séjourné C, Ettahar N, Lemaire X, Vuotto F, Goffard A, Behillil S, Enouf V, Caro V, Mailles A, Che D, Manuguerra JC, Mathieu D, Fontanet A, van der Werf S; MERS-CoV study group. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission. Lancet. 2013 Jun 29;381(9885):2265-72.

Guery B, van der Werf S. Coronavirus: need for a therapeutic approach. Lancet Infect Dis. 2013 Sep;13(9):726-7.

Mailles A, Blanckaert K, Chaud P, van der Werf S, Lina B, Caro V, Campese C, Guéry B, Prouvost H, Lemaire X, Paty MC, Haeghebaert S, Antoine D, Ettahar N, Noel H, Behillil S, Hendricx S, Manuguerra JC, Enouf V, La Ruche G, Semaille C, Coignard B, Lévy-Bruhl D, Weber F, Saura C, Che D; investigation team. First cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission, France, May 2013. Euro Surveill. 2013 Jun 13;18(24).

Mosnier E, Mahamat A, Carvalho L, Nacher M, Abboud P, Chappert JL, Rousset D, Djossou F. Concurrent influenza and shigellosis outbreak in a gold mining site, French Guiana, March 2013.  Am J Trop Med Hyg . in press.

Opatowski L, Varon E, Dupont C, Temime L, van der Werf S, Gutmann L, Boëlle PY, Watier L, Guillemot D. Assessing pneumococcal meningitis association with viral respiratory infections and antibiotics: insights from statistical and mathematical models. Proc Biol Sci. 2013 Jun 19;280(1764):20130519.

Ploin D, Chidiac C, Carrat F, Cohen B, Javouhey E, Mayaud C, Descenclos JC, Lina B, Leport C, the Fluco study group. Complications and factors associated with severity of influenza in hospitalized children and adults during the pandemic wave of A(H1N1)pdm2009 infections-The Fluco French cohort. J Clin Virol 2013;58:114-9.

Pozo F, Lina B, Andrade HR, Enouf V, Kossyvakis A, Broberg E, et al. Guidance for clinical and public health laboratories testing for influenza virus antiviral drug susceptibility in Europe. J Clin Virol 2013;57:5-12.

Bonduelle O, Yahia N, Siberil S, Benhabiles N, Carrat F, Krivine A, Rozenberg F, Dimitrov J, Kaveri SV, Curjol A, Tindel M, Louet M, Desert F, Launay O, Loulergue P, Badre G, Katlama C, Bricaire F, Samri A, Rousset D, van der Werf S, Jauréguiberry S, Combadiere B.  Longitudinal and integrative biomodeling of effector and memory immune compartments after inactivated influenza vaccination.J Immunol. 2013 Jul 15;191(2):623-31.

Bone A, Guthmann JP, Assal A, Rousset D, Degeorges A, Morel P, et al. Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France. PLoS One 2012;7:e33056.

Carrat F, Duval X, Tubach F, Mosnier A, van der Werf S, Tibi A, Blanchon T, Leport C, Flahault A, Mentré F; the BIVIR study group. Effect of oseltamivir, zanamivir or oseltamivir-zanamivir combination treatments on transmission of influenza in households. Antivir Ther. 2012;17(6):1085-1090.

Heraud JM*, Njouom R*, Rousset D*, Kadjo H, Caro V, Ndiaye MN, Victoir K, Collard JM, Orelle A, Yekwa EL, Ekaza E, Razanajatovo NH, Adamou L, Biscornet L, Enouf V, van der Werf S, Diop OM. Spatiotemporal circulation of influenza viruses in 5 African countries during 2008-2009: a collaborative study of the Institut Pasteur International Network. J Infect Dis. 2012 Dec 15;206 Suppl 1:S5-13.

Launay O, Krivine A, Charlier C, Truster V, Tsatsaris V, Lepercq J, Ville Y, Avenell C, Andrieu T, Rozenberg F, Artiguebielle F, Tréluyer JM, Goffinet F; Inserm COFLUPREG Study Group. Low rate of pandemic A/H1N1 2009 influenza infection and lack of severe complication of vaccination in pregnant women: a prospective cohort study. PLoS One. 2012;7(12):e52303.

Legoff J, Rousset D, Abou-Jaoudé G, Scemla A, Ribaud P, Mercier-Delarue S, Caro V, Enouf V, Simon F, Molina JM, van der Werf S. I223R Mutation in Influenza A(H1N1)pdm09 Neuraminidase Confers Reduced Susceptibility to Oseltamivir and Zanamivir and Enhanced Resistance with H275Y. PLoS One. 2012;7(8):e37095.

Luytjes W, Enouf V, Schipper M, Gijzen K, Liu WM, van der Lubben M, Meijer A, van der Werf S, Soethout EC. HI responses induced by seasonal influenza vaccination are associated with clinical protection and with seroprotection against non-homologous strains. Vaccine. 2012 Jul 27;30(35):5262-9. Epub 2012 Jun 9.

Martirosyan L, Paget WJ, Jorgensen P, Brown CS, Meerhoff TJ, Pereyaslov D, Mott JA; EuroFlu group. 2012 The community impact of the 2009 influenza pandemic in the WHO European region: a comparison with historical seasonal data from 28 countries. BMC Infect Dis. 2012 Feb 10;12:36.

Rudrawar S, Kerry PS, Rameix-Welti MA, Maggioni A, Dyason JC, Rose FJ, van der Werf S, Thomson RJ, Naffakh N, Russell RJ, von Itzstein M. Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility. Org Biomol Chem. 2012 Nov 21;10(43):8628-39.

Vittecoq M, Grandhomme V, Champagnon J, Guillemain M, Crescenzo-Chaigne B, Renaud F, Thomas F, Gauthier-Clerc M, van der Werf S. High influenza a virus infection rates in mallards bred for hunting in the camargue, South of france. PLoS One. 2012;7(8):e43974.

Vittecoq M, Grandhomme V, Simon G, Herve S, Blanchon T, Renaud F, Thomas F, Gauthier-Clerc M, van der Werf S. Study of influenza A virus in wild boars living in a major duck wintering site. Infect Genet Evol. 2012 Mar;12(2):483-6. Epub 2011 Dec 17.

Escuret V, Cornu C, Boutitie F, Enouf V, Mosnier A, Bouscambert-Duchamp M, Gaillard S, Duval X, Blanchon T, Leport C, Gueyffier F, Van Der Werf S, Lina B. Oseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) virus infections. Antiviral Res. 2012 Nov;96(2):130-7. doi: 10.1016/j.antiviral.2012.08.002. Epub 2012 Aug 14.

Bone A, Guthmann JP, Assal A, Rousset D, Degeorges A, Morel P, Valette M, Enouf V, Jacquot E, Pelletier B, Le Strat Y, Pillonel J, Fonteneau L, van der Werf S, Lina B, Tiberghien P, Lévy-Bruhl D. 2012. Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France. PLoS One. 2012;7(3):e33056. Epub 2012 Mar 22.

Carrat F, Duval X, Tubach F, Mosnier A, van der Werf S, Tibi A, Blanchon T, Leport C, Flahault A, Mentré F; the BIVIR study group. 2012. Effect of oseltamivir, zanamivir or oseltamivir-zanamivir combination treatments on transmission of influenza in households. Antivir Ther. 2012;17(6):1085-1090.

WHO Writing Group, Ampofo WK, Baylor N, Cobey S, Cox NJ, Daves S, Edwards S, Ferguson N, Grohmann G, Hay A, Katz J, Kullabutr K, Lambert L, Levandowski R, Mishra AC, Monto A, Siqueira M, Tashiro M, Waddell AL, Wairagkar N, Wood J, Zambon M, Zhang W. Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010. Influenza Other Respi Viruses. 2012 Mar;6(2):142-52

Amato-Gauci, A., P. Zucs, R. Snacken, B. Ciancio, V. Lopez, E. Broberg, P. Penttinen, and A. Nicoll ; A; European Influenza Surveillance Network EISN. 2011. Surveillance trends of the 2009 influenza A(H1N1) pandemic in Europe. Euro Surveill 16.

Barakat, A., A. Benjouad, J. C. Manuguerra, R. El Aouad, and S. Van der Werf. 2011. Virological surveillance in Africa can contribute to early detection of new genetic and antigenic lineages of influenza viruses. J Infect Dev Ctries 5:270-277.

Blanchon, T., F. Mentré, C. Caharlois-Ou, Q. Dornic, A. Mosnier, M. Bouscambert-Duchamp, F. Carrat, X. Duval, V. Enouf, and C. Leport. 2011. Factors associated with clinical and virological response in patients treated with oseltamivir or zanamivir for influenza A during the 2008-2009 winter season. . Clinical Microbiology and Infection.

Freund, R., C. Le Ray, C. Charlier, C. Avenell, V. Truster, J. M. Treluyer, D. Skalli, Y. Ville, F. Goffinet, and O. Launay ; Inserm COFLUPREG Study Group 2011. Determinants of non-vaccination against pandemic 2009 H1N1 influenza in pregnant women: a prospective cohort study. PLoS One 6:e20900.

Launay, O., C. Desaint, C. Durier, P. Loulergue, X. Duval, C. Jacomet, G. Pialoux, J. Ghosn, F. Raffi, D. Rey, F. Ajana, N. Colin de Verdiere, J. Reynes, V. Foubert, F. Roman, J. M. Devaster, J. F. Delfraissy, and J. P. Aboulker ; ; ANRS 151 HIFLUVAC Study Group and the French Clinical Vaccinology Network (Réseau National d'Investigation Clinique en Vaccinologie REIVAC).  2011. Safety and immunogenicity of a monovalent 2009 influenza A/H1N1v vaccine adjuvanted with AS03A or unadjuvanted in HIV-infected adults: a randomized, controlled trial. J Infect Dis 204:124-134.

Lina, B., M. Bouscambert, V. Enouf, D. Rousset, M. Valette, and S. van der Werf. 2011. S-OtrH3N2 viruses: use of sequence data for description of the molecular characteristics of the viruses and their relatedness to previously circulating H3N2 human viruses. Euro Surveill 16:20039.

Papillard-Marechal, S., V. Enouf, A. Schnuriger, A. Vabret, E. Macheras, M. A. Rameix-Welti, B. Page, F. Freymuth, S. van der Werf, A. Garbarg-Chenon, B. Chevallier, J. L. Gaillard, and E. Gault. 2011. Monitoring epidemic viral respiratory infections using one-step real-time triplex RT-PCR targeting influenza A and B viruses and respiratory syncytial virus. J Med Virol 83:695-701.

Pelat, C., A. Falchi, F. Carrat, A. Mosnier, I. Bonmarin, C. Turbelin, S. Vaux, S. van der Werf, J. M. Cohen, B. Lina, T. Blanchon, and T. Hanslik. 2011. Field effectiveness of pandemic and 2009-2010 seasonal vaccines against 2009-2010 A(H1N1) influenza: estimations from surveillance data in France. PLoS One 6:e19621.

Pelletier, I., D. Rousset, V. Enouf, GROG, F. Colbère-Garapin, S. van der Werf, and N. Naffakh. 2011. Highly heterogeneous temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates, northern France. Eurosurveillance 16:16-18.

Rameix-Welti, M. A., S. Munier, S. Le Gal, F. Cuvelier, F. Agou, V. Enouf, N. Naffakh, and S. van der Werf. 2011. Neuraminidase of 2007-2008 influenza A(H1N1) viruses shows increased affinity for sialic acids due to the D344N substitution. Antivir Ther 16:597-603.

Rosenkrands, I., C. Vingsbo-Lundberg, T. J. Bundgaard, T. Lindenstrom, V. Enouf, S. van der Werf, P. Andersen, and E. M. Agger. 2011. Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes. Vaccine 2011 29:6283-6291.

Devaux I, Kreidl P, Penttinen P, Salminen M, Zucs P, Ammon A; ECDC influenza surveillance group; national coordinators for influenza surveillance. Initial surveillance of 2009 influenza A(H1N1) pandemic in the European Union and European Economic Area, April-September 2009.Euro Surveill. 2010 Dec 9;15(49). pii: 19740. Erratum in: Euro Surveill. 2011;16(3). pii: 19769. Gunson, Rory [added].

Rudrawar S, Dyason JC, Rameix-Welti MA, Rose FJ, Kerry PS, Russell RJ, van der Werf S, Thomson RJ, Naffakh N, von Itzstein M. Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat Commun. 2010 Nov 16;1:113.

Duval X, van der Werf S, Blanchon T, Mosnier A, Bouscambert-Duchamp M, Tibi A, Enouf V, Charlois-Ou C, Vincent C, Andreoletti L, Tubach F, Lina B, Mentré F, Leport C; Bivir Study Group. Efficacy of oseltamivir-zanamivir combination compared to each monotherapy for seasonal influenza: a randomized placebo-controlled trial. PLoS Med. 2010 Nov 2;7(11):e1000362. doi: 10.1371/journal.pmed.1000362. Erratum in: PLoS Med. 2010;7(12) doi: 10.1371/annotation/ca448e7c-fbbc-43e9-9981-108c9bfa8bce.

Lebarbenchon C, Chang CM, Grandhomme V, Dietrich M, Kayser Y, Elguero E, Renaud F, Thomas F, van der Werf S, Gauthier-Clerc M. Avian influenza circulation in the Camargue (south of France) during the 2006-07 season. Avian Dis. 2010 Mar;54(1 Suppl):446-9.

Combadière B, Vogt A, Mahé B, Costagliola D, Hadam S, Bonduelle O, Sterry W, Staszewski S, Schaefer H, van der Werf S, Katlama C, Autran B, Blume-Peytavi U. Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial. PLoS One. 2010 May 26;5(5):e10818. doi: 10.1371/journal.pone.0010818.

Gijzen K, Liu WM, Visontai I, Oftung F, van der Werf S, Korsvold GE, Pronk I, Aaberge IS, Tütto A, Jankovics I, Jankovics M, Gentleman B, McElhaney JE, Soethout EC. Standardization and validation of assays determining cellular immune responses against influenza. Vaccine. 2010 Apr 26;28(19):3416-22. doi: 10.1016/j.vaccine.2010.02.076. Epub 2010 Mar 4.

Massin P, Kuntz-Simon G, Barbezange C, Deblanc C, Oger A, Marquet-Blouin E, Bougeard S, van der Werf S, Jestin V. Temperature sensitivity on growth and/or replication of H1N1, H1N2 and H3N2 influenza A viruses isolated from pigs and birds in mammalian cells. Vet Microbiol. 2010 May 19;142(3-4):232-41. doi: 10.1016/j.vetmic.2009.10.012. Epub 2009 Oct 28.

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