Virus des infections respiratoires (dont la grippe)

Activités de recherche du CNR virus des infections respiratoires (dont la grippe)

  1. Virus des infections respiratoires (dont la grippe)
  2. Activités de recherche du CNR virus des infections respiratoires (dont la grippe)

PRINCIPAUX THÈMES DE RECHERCHE DU CNR :

  • Évolution génétique des virus grippaux
  • Déterminants de restriction d’hôte et de transmission inter-espèces et identification de nouvelles cibles thérapeutiques
  • Potentiel zoonotique des virus influenza D et comparaison avec les virus influenza C.
  • vRNP des virus influenza : biosynthèse, assemblage et interactions durant l’empaquetage et/ou le réassortiment génétique
  • Détournement de la biogenèse des ribosomes et de la machinerie transcriptionnelle lors de l’infection virale.
  • Pathogenèse des virus influenza: rôle des facteurs de l’hôte au cours de l’inflammation et des interactions hôte-virus impliquées dans les surinfections bactériennes.

PUBLICATIONS 2017-2018

Publications nationales

Equipes de surveillance de la grippe* Surveillance de la grippe en France, Saison 2017-2018, Bull Epidémiol Hebd ; sous presse

van der Werf S, Morfin F, Lina B. Virus de la grippe. In : REMIC., sous presse

Lina B. Grippe. EMC – Savoirs et soins infirmiers (MAJ Traité). In press

Janin H, Vilain Parce A, Kaminski H, Valette M, Cazanave C. [The 2015-2016 influenza epidemic: Late onset, clinical severity and emergence of the B Victoria virus]. Med Mal Infect. 2018 Feb;48(1):73-74.

Gaymard A, Frobert E, Lina B, Escuret V. (2017) Infections humaines par les virus influenza A (H7N9) : émergence des virus, évolution et risque pandémique. Virologie, 2017, 21(6) :255-264

Equipes de surveillance de la bronchiolite (2017) Surveillance de la bronchiolite en France, saison 2016-2017 Bull Epidémiol Hebd ; 31 : 650-657.

Equipes de surveillance de la grippe (2017) Surveillance de la grippe en France, Saison 2016-2017, Bull Epidémiol Hebd ; 22 : 466-475

 

Publications internationales

Kissling E, Valenciano M, Pozo F, Vilcu AM, Reuss A, Rizzo C, Larrauri A, Horváth JK, Brytting M, Domegan L, Korczyńska M, Meijer A, Machado A, Ivanciuc A, Višekruna Vučina V, van der Werf S, Schweiger B, Bella A, Gherasim A, Ferenczi A, Zakikhany K, O Donnell J, Paradowska-Stankiewicz I, Dijkstra F, Guiomar R, Lazar M, Kurečić Filipović S, Johansen K, Moren A; I-MOVE/I-MOVE+ study team. (2018) 2015/16 I-MOVE/I-MOVE+ multicentre case-control study in Europe: Moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage-mismatched influenza B among children. Influenza Other Respir Viruses. 2018 Jul;12(4):423-437

Lefeuvre C, Behillil S, Triau S, Monteiro-Rodrigues A, Templier F, Tran CT, Le Guillou-Guillemette H, Lunel-Fabiani F, Enouf V, Ducancelle A. (2018) Fatal Myopericarditis Following an Influenza A (H3N2) Infection. Am J Case Rep. 2018 May 8;19:540-544

Vilcu AM, Souty C, Enouf V, Capai L, Turbelin C, Masse S, Behillil S, Valette M, Guerrisi C, Rossignol L, Blanchon T, Lina B, Hanslik T, Falchi A. (2018) Estimation of seasonal influenza vaccine effectiveness using data collected in primary care in France: comparison of the test-negative design and the screening method. Clin Microbiol Infect. 2018 Apr;24(4):431

Domenech de Cellès M, Arduin H, Varon E, Souty C, Boëlle PY, Lévy-Bruhl D, van der Werf S, Soulary J-C, Guillemot D, Watier L, Opatowski L (2018) Characterizing and Comparing the Seasonality of Influenza-Like Illnesses and Invasive Pneumococcal Diseases Using Seasonal Waveforms. Am J Epidemiol, 187(5):1029-1039.

Lekana-Douki SE, Behillil S, Enouf V, Leroy EM, Berthet N. (2018) Detection of human bocavirus-1 in both nasal and stool specimens from children under 5 years old with influenza-like illnesses or diarrhea in Gabon. BMC Res Notes. 2018 Jul 20;11(1):495.

Droz N, Enouf V, Bidet P, Mohamed D, Behillil S, Simon AL, Bachy M, Caseris M, Bonacorsi S, Basmaci R. (2018) Temporal Association Between Rhinovirus Activity and Kingella kingae Osteoarticular Infections. J Pediatr. 2018 Jan;192:234-239.e2.

Mosnier A, Daviaud I, Casalegno JS, Ruetsch M, Burugorri C, Nauleau E, Bui TT, Fleury H, Lina B, van der Werf S, Cohen JM (2017) Influenza B burden during seasonal influenza epidemics in France. Med Mal Infect 47(1):11-17.

Biquand E, Poirson J, Karim M, Declercq M, Malausse N, Cassonnet P, Barbezange C, Straub ML, Jones L, Munier S, Naffakh N, van der Werf S, Jacob Y, Masson M, Demeret C. (2017) Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans. mSphere. 2017 Nov 22;2(6). pii: e00330-17. doi: 10.1128/mSphere.00330-17.

Minodier L, Masse S, Capai L, Blanchon T, Ceccaldi PE, van der Werf S, Hanslik T, Charrel NR, Falchi A. (2017) Risk factors for seasonal influenza virus detection in stools of patients consulting in general practice for acute respiratory infections in France, 2014-2016. Influenza Other Respir Viruses. 2017 Nov 16. doi: 10.1111/irv.12523.

Auffray C, Sagner M, ……van der Werf S, ……Sanz F, Nobrega F (2017) Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing, PROGREVMED 2017; 2: e006

Vilcu AM, Souty C, Enouf V, Capai L, Turbelin C, Masse S, Behillil S, Valette M, Guerrisi C, Rossignol L, Blanchon T, Lina B, Hanslik T, Falchi A. (2017) Estimation of seasonal influenza vaccine effectiveness using data collected in primary care in France: comparison of the test-negative design and the screening method. Clin Microbiol Infect. 2017 Sep 9. pii: S1198-743X(17)30501-3

Souty C, Vilcu AM, Capai L, van der Werf S, Valette M, Blanchon T, Lina B, Behillil S, Hanslik T, Falchi A. (2017) Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France. J Clin Virol. 2017 Oct;95:1-4.

Parpaleix A, Boyer L, Wiedemann A, Lacabaratz C, Margarit L, Enouf V, Le Corvoisier P, Lino A, Covali-Noroc A, Housset B, Chouaid C, Maitre B, Lévy Y, Lelièvre JD, Adnot S. (2017) Impaired Humoral and Cellular Immune Responses to Influenza Vaccination in COPD Patient. J Allergy Clin Immunol. 2017 Sep 7. pii: S0091-6749(17)31428-8.

Crescenzo-Chaigne B, Barbezange CV, Leandri S, Roquin C, Berthault C, van der Werf S (2017) Incorporation of the influenza A virus NA segment into virions does not require cognate non-coding sequences. Sci Rep 7:43462.

Langevin S, Pichon M, Smith E, Morrison J, Bent Z, Green R, Baker K, Solberg O, Gillet Y, Javouhey E, Lina B, Katze M, and Josset L. (2017) Early nasopharyngeal microbial signatures are associated with severe influenza in children: a retrospective pilot study Journal of General Virology, 2017 98(10):2425-2437

Pichon M, Gaymard A, Josset L, Valette M, Millat G, Lina B, Escuret V. Characterization of oseltamivir-resistant influenza virus populations in immunosuppressed patients using digital-droplet PRC: Comparison with qPCR and next generation sequencins analysis. Antiviral Research, 145 (2017) 160-167.

Flicoteaux R, Protopopescu C, Tibi A, Blanchon T, Werf SV, Duval X, Mosnier A, Charlois-Ou C, Lina B, Leport C, Chevret S. Factors associated with non-persistence to oral and inhaled antiviral therapies for seasonal influenza: a secondary analysis of a double-blind, multicentre, randomised clinical trial. BMJ Open. 2017 Jul 10;7(7):e014546

Dubois J, Cavanagh MH, Terrier O, Hamelin MÈ, Lina B, Shi R, Rosa-Calatrava M, Boivin G. Mutations in the fusion protein heptad repeat domains of human metapneumovirus impact on the formation of syncytia. J Gen Virol. 2017 Jun;98(6):1174-1180.

Panthu B, Terrier O, Carron C, Traversier A, Corbin A, Balvay L, Lina B, Rosa-Calatrava M, Ohlmann T. The NS1 Protein from Influenza Virus Stimulates Translation Initiation by Enhancing Ribosome Recruitment to mRNAs. J Mol Biol. 2017 Apr 20. pii: S0022-2836(17)30182-1

Casalegno JS, Eibach D, Valette M, Enouf V, Daviaud I, Behillil S, Vabret A,Soulary JC, Benchaib M, Cohen JM, van der Werf S, Mosnier A, Lina B. Performance of influenza case definitions for influenza community surveillance: based on the French influenza surveillance network GROG, 2009-2014. Euro Surveill. 2017 Apr 6;22(14)

Pichon M, Gaymard A, Lebail-Carval K, Frobert E, Beaufils E, Chene G,Tommasino M, Lina B, Gaucherand P, Gautheret-Dejean A, Bonnafous P, Gheit T, Buenerd A, Lamblin G, Mekki Y. Vaginal Neoplasia Induced by an Unusual Papillomavirus Subtype in a Woman with Inherited Chromosomally Integrated Human Herpesvirus Type 6A. Gynecol Obstet Invest. 2017;82(3):307-310

Mosnier A, Daviaud I, Casalegno JS, Ruetsch M, Burugorri C, Nauleau E, Bui TT, Fleury H, Lina B, van der Werf S, Cohen JM (2017) Influenza B burden during seasonal influenza epidemics in France. Med Mal Infect 47(1):11-17

Mosnier A, Daviaud I, Caini S, Berche H, Mansuy JM, van der Werf S, Cohen JM, Lina B (2017) Does seasonal vaccination affect the clinical presentation of influenza among the elderly? A cross-sectional analysis in the outpatient setting in France, 2003-2014. Vaccine 35(16):2076 -2083.

Harris KA, Freidl GS, Munoz OS, von Dobschuetz S, De Nardi M, Wieland B, Koopmans MPG, Stark KDC, van Reeth K, Dauphin G, Meijer A, de Bruin E, Capua I, Hill AA, Kosmider R, Banks J, Stevens K, van der Werf S, Enouf V, van der Meulen K, Brown IH, Alexander DJ, Breed AC, FLURISK consortium (2017) Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers. Ecohealth. 14(2):342-360.

Briand FX, Schmitz A, Ogor K, Le Prioux A, Guillou-Cloarec C, Guillemoto C, Allee C, Le Bras MO, Hirchaud E, Quenault H, Touzain F, Cherbonnel-Pansart M, Lemaitre E, Courtillon C, Gares H, Daniel P, Fediaevsky A, Massin P, Blanchard Y, Eterradossi N, van der Werf S, Jestin V, Niqueux E (2017) Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential. Euro Surveill 22(9).

 

 

Mis à jour le 17/10/2018

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