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Document de presse | 2019.07.10
Anaphylactic shock: IgG antibodies and neutrophils play an unexpected role
Anaphylactic shock, an exacerbated allergic reaction that can prove fatal, is sometimes caused by the use of drugs during surgery. In most of these extreme reactions, evidence can be provided that patients have anti-drug antibodies of the IgE class. In 10 to 20% of anaphylactic cases evidence for the involvement of anti-drug IgE is lacking. Anti-drug IgE enable activation of mast cells and...
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Document de presse | 2019.07.11
High-risk pregnancy: the interferon effect
Discovery of a cellular mechanism involved in abnormal placental development during some high-risk pregnancies.High-risk pregnancies occur frequently and may be caused by various factors. It is estimated that 10 to 20% of pregnant women miscarry during their first trimester of pregnancy. Slow fetal growth may also arise as a result of maternal infection with certain microbes, parasites or viruses...
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News | 2019.07.08
High-level microscopy unveils bacteria’s adaptation mechanisms
Microorganisms are constantly challenged by a variety of environmental stresses. In many bacteria, the stressosome, a key inducer of the stress response is a very large machine that responds to diverse environmental changes. However, how the stressosome transmits stress signals from the environment has remained elusive. Thanks to a high-resolution microscope Titan KriosTM, researchers from the...
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Article | 2019.07.09
Cours internationaux - 2019
TITLEORGANIZERINSTITUTEDURATION DATECOURSE PLACEAtelier NGS : Epidémiologie génomique, microbiome et métagénomique pour l'Afrique et l'Océan IndienJean-Marc COLLARDInstitut Pasteur Madagascar7 daysTo Be DefinedInstitut Pasteur MadagascarSystèmes d'information géographique appliquées à l'épidémiologie : Introduction au logiciel QGIS 2. Analyses multicritères spacialisées : Application en...
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Document de presse | 2019.07.12
HIV: reprogramming cells to control infection
Cells from the rare individuals who naturally control HIV infection have been the focus of investigation for nearly 15 years with the aim of elucidating their specific features. Following research on the ANRS CO21 CODEX and CO6 PRIMO cohorts, scientists from the Institut Pasteur have described the characteristics of CD8 immune cells in these "HIV controller" subjects. The unique antiviral power...
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News | 2019.07.16
Immature heart cells persist in the adult heart and react to infarction
Cardiovascular diseases are a major cause of mortality and morbidity worldwide. After myocardial infarction, heart cells (or cardiomyocytes) die and are replaced by fibrotic tissue leading to impaired cardiac function. The assessment of the regenerative capacity of the heart has always been compromised by the lack of signatures to characterize cardiomyocytes. Researchers from the Institut Pasteur...
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News | 2019.07.23
Shedding light on almost indestructible archaeal pili
Extremophiles are organisms that have evolved to thrive under extremely harsh environmental conditions. Scientists have always been mystified by how these organisms survive in such settings and especially how extracellular appendages, such as pili, remain stable. Researchers from the Institut Pasteur, in collaboration with colleagues from the University of Virginia revealed how sugars make those...
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News | 2019.07.17
The Institut Pasteur launches a Scientific Platform in the university of São Paulo Research and Innovation Center
On July 4, the Institut Pasteur, an internationally renowned center for biomedical research and a French non-profit foundation specialized in infectious diseases, has inaugurated the Pasteur-USP Scientific Platform in the University of São Paulo Research and Innovation Center (Inova USP) which is hosting 17 laboratories dedicated to innovation. This platform will focus on the study of pathogens...
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News | 2019.07.11
A fast likelihood method to reconstruct and visualize ancestral scenarios
The Institut Pasteur is at the forefront of computational biology research. Scientists in the Evolutionary Bioinformatics Unit (part of Institut Pasteur and CNRS Unit, USR 3756) recently developed the PastML program. This tool, based on decision-theory concepts, infers "ancestral scenarios" that describe the evolution of traits or characters along phylogenetic trees. The characters can be very...
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News | 2019.07.12
Wolbachia, bacteria to combat dengue
The first mosquitoes carrying Wolbachia, bacteria that prevent them from transmitting arboviruses (including dengue, Zika and chikungunya), were released on Wednesday July 10, 2019 in Nouméa, New Caledonia, as part of the World Mosquito Program,* which involves teams from the Institut Pasteur de Nouvelle-Calédonie. The aim of this program is to encourage mosquitoes infected with Wolbachia to...
