1. Article | 2019.06.25

   Novel approaches to diagnosis, vaccination and therapy (12 entities)

   This thematic area gathers investigators with a common interest in translational research. It addresses the design, development and evaluation of candidate vaccines, therapeutics, diagnosis tools, and immunotherapies, for conversion of scientific breakthroughs into improved human health.

2. Article | 2019.06.18

   Parasites

   Teams of the Departments of Parasites and Insect Vectors and of Structural Biology and Chemistry are dedicated to characterize the dissemination and the mechanisms of drug resistance of parasitic infections and to develop alternative strategies to fight them.

3. Article | 2019.06.25

   Pathogen genomics and microbiota (8 entities)

    Research in this thematic area explores the genomes of infectious agents in relation with their evolution. It also investigates the regulation of the microbiota composition and the mechanisms by which microbiota dysbiosis influences antimicrobial immunity.

4. Article | 2019.06.25

   Pathogen biology (12 entities)

   In addition to causing many infectious diseases, pathogens provide insightful information on fundamental biological processes. Research in this thematic area investigates the mechanisms underpinning the virulence of pathogens of global public health and/or veterinary concern.

5. Article | 2021.08.03

   Sensory Disorders

    Department of NeurosciencesAziz El-Amraoui - Progressive sensory disorders, pathophysiology and therapyHearing and vision are essential for every significant activity of daily life, ranging from social interactions and mobility to an appreciation of music, art, and nature. Because of their high prevalence, untreated decline of these sensory deficits has a vast economic & societal...

6. Article | 2019.06.18

   Transversal

   Teams from the Department of Structural Biology and Chemistry and from Computational Biology develop new molecules, technologies and approaches to detect and fight AMR.

7. Article | 2019.08.06

   Vaccinology and Immunotherapy Initiative: Innovation – Vaccine Candidates

   The Institut Pasteur has a distinguished history of vaccine development as a means to improve global health. A stronghold of the Institut Pasteur in vaccines is the development of novel technologies for vaccine design and delivery with several candidates currently under clinical evaluation, either licensed to development and commercialization partners or under Institut Pasteur sponsorship.

8. Article | 2019.08.06

   Vaccinology and Immunotherapy Initiative: Clinical Research

   Clinical Research in Vaccinology and Immunotherapy at Institut Pasteur includes clinical studies with the advanced vaccine candidates developed by Institut Pasteur (described as part of the Innovation – Vaccine candidates, immune-monitoring of Institut Pasteur sponsored clinical trials as well as in collaboration with partners, and cohort and surveillance studies to uncover the disease-specific...

9. Article | 2021.08.03

   Understanding mechanisms of brain function

   Department of Cell Biology & InfectionSandrine Etienne-Manneville - Astrocytic responses to inflammatory situationsAstrocytes form the majority of glial cells of the central nervous system. They play a key role in brain homeostasis, they serve as physical and nutritional support for neurons and they directly participate in synaptic transmission. In inflammatory situations, such as...

10. Article | 2019.08.06

    Vaccinology and Immunotherapy Initiative: Fundamental Research

    Many different fields of the highly recognized fundamental research pursued at the Institut Pasteur are connected to vaccinology or immunotherapy. These include pathogen identification and characterization, structural analysis, in silico approaches, analysis of mechanisms to potentially enhance antigen immunogenicity and/or delivery or to identify specific immunotherapy targets, effects of...

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