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Vidéo | 2025.03.20
Mini-organs for science!
Hair-sized mini-brains and mini-lungs... Welcome to the fascinating world of organoids!These 3D structures, created in the laboratory from stem cells, mimic the functions of real organs. A major asset for understanding brain development, testing treatments or studying infection by viruses such as SARS-CoV-2.Thanks to scientists like Barbara Fonseca, a researcher at the Biomaterials and...
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News | 2025.03.12
A step closer to understanding our immune system to improve therapies for chronic inflammatory diseases
The Institut Pasteur, in collaboration with Johnson & Johnson Innovative Medicine Research & Development, uncovers the interactions between a molecule (the cytokine interleukine-23 (IL-23)) produced by the immune system and so-called mucosal-associated invariant T (MAIT) cells, which are involved early in the immune response to fight pathogens. Chronic inflammatory diseases are...
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News | 2024.10.08
Can lymphoid organs-on-chip be used to evaluate the effectiveness of booster vaccines?
Researchers at the Institut Pasteur, a Carnot-labeled institute, have developed an innovative technology: "lymphoid organ-on-chip" devices that are capable of simulating the human immune system’s response to booster vaccines. This breakthrough could provide a versatile preclinical system to evaluate vaccine candidates in the face of rapidly evolving pandemics such as that caused by the SARS-CoV-2...
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News | 2025.03.18
Enodia Therapeutics, a spin-off from the Institut Pasteur, develops new approach for targeted protein degradation
The Institut Pasteur, a Carnot institute since 2007, and the start-up studio Argobio announced in February 2025 the launch of Enodia Therapeutics, a groundbreaking French biotech company dedicated to block and degrade disease-causing proteins for treating cancer, inflammatory diseases and viral infections. The platform leverages state-of-the-art generative artificial intelligence (AI) to design...
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Article | 2025.03.19
People at the heart of our mission
The Institut Pasteur puts people at the heart of its mission, in the firm belief that excellence in scientific research is achieved through the commitment of individuals and the support of those who believe in its work. This involves valuing each and every one of our employees, from scientists to administrative and technical staff. Every member of our community contributes to the success and...
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Article | 2025.03.11
Ethics, Integrity and Compliance
Aware of the inherent challenges associated with science and scientific applications, the Institut Pasteur promotes research that is responsible, ethical, fair and respectful of human dignity. It works within the framework of applicable legislation and regulations, and is committed to the principles of transparency and anti-corruption. Several independent committees in different areas oversee...
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Article | 2025.03.11
Strengthening and promoting ethics
The Institut Pasteur Ethics Committee (CEIP) encourages discussion on the societal and ethical dimensions of research and practices. It is also involved in improving implementation and coordination in the areas of ethics, professional conduct, scientific integrity and responsible research. The CEIP works with the other specialist committees to develop institutional awareness of these topics.
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Article | 2025.03.11
Reflecting on research practices
The Institut Pasteur's Research Volunteers Committee (COVOL) is a forum for reflection on research from the participants' viewpoint. It includes volunteers who have chosen to be involved in the Institut Pasteur's research, often by donating samples or data, and serves as a bridge between the institution and society. It also plays a part in improving the Institut Pasteur's practices through the...
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Article | 2025.03.10
Assessing ethical acceptability
For any research involving humans or animals, scientists must demonstrate compatibility with applicable ethical standards and legal requirements. At the Institut Pasteur, two bodies assess the ethical dimensions of research protocols: the Committee for Ethics in Animal Experimentation (CETEA) and the Institut Pasteur Institutional Review Board (IRB-IP).
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Article | 2025.03.10
Monitoring sensitive situations and providing support
Some situations require closer monitoring, either when requested by a funder or because they represent a specific risk (for example a health or environmental risk or a conflict of interest). In these cases, the Institut Pasteur supports the teams concerned via two permanent operational groups: the Dual Use Liaison Group (DULG) and the Conflict of Interest Review Board (GELI). An ad hoc committee...
