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Document de presse | 2016.01.27
Tuberculosis: discovery of a critical stage in the evolution of the bacillus towards pathogenicity
It is the disappearance of a glycolipid from the bacterial cell envelope during evolution that may have considerably increased the virulence of tuberculosis bacilli in humans. Scientists from the CNRS, the Institut Pasteur and the Université Toulouse III – Paul Sabatier[1] have shown that this disappearance modified the surface properties of Mycobacterium tuberculosis, favoring its...
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News | 2020.12.03
HIV: one stage in replication may occur in macrophage nuclei
Understanding the replication mechanisms of HIV in the body is vital for the development of more targeted treatments. Research into macrophages is particularly crucial, since these immune cells are the first line of cellular defense against infectious agents, and HIV accumulates silently in them, making them a reservoir for the virus – even in people receiving treatment. Scientists from the...
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News | 2016.01.26
Tuberculosis: discovery of a critical stage in the evolution of the bacillus towards pathogenicity
It is the disappearance of a glycolipid from the bacterial cell envelope during evolution that may have considerably increased the virulence of tuberculosis bacilli in humans. Scientists have shown that this disappearance modified the surface properties of Mycobacterium tuberculosis, favoring its aggregation in "cords" and increasing its pathogenicity. These findings, which enable a...
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Article | 2019.06.20
Cancer Biology
Understanding the main stages in tumor development to identify markers for very early diagnosis and new therapeutic targets.
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News | 2024.12.03
The essential role of the gene Nr5a2 in embryogenesis
Scientists have elucidated the role of the gene Nr5a2 in the first stages of embryonic development in mammals. This research sheds new light on a biological process that is not yet fully understood.
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News | 2022.09.01
Malaria: blood stage of the parasite recreated in vivo to help tackle the disease
By engrafting human hematopoietic stem cells into mice, a team from the Institut Pasteur, Inserm and the CNRS was able to maintain the Plasmodium vivax parasite in vivo, providing a novel model to explore therapeutic strategies.
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Document de presse | 2005.06.14
From stem cells to skeletal muscle : the vital stages deciphered
A laboratory from the Institut Pasteur, associated with the CNRS has taken a determining step towards the understanding of the evolution of skeletal muscle stem cells. Using specific genetic markers, researchers have shown four characteristic stages that mark out the development of the muscle cells from a population of stem cells, which they have identified. This discovery has very important...
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Document de presse | 2013.07.04
Transmissibility of new coronavirus too low to trigger global epidemic at this stage
In a study published online on July 5, 2013 for the medical journal The Lancet, a team from the Institut Pasteur suggests that the coronavirus MERS-CoV, in its current form, is not capable of triggering a global epidemic. However, it should not be assumed that the virus’ transmissibility will not increase if the virus mutates or if transmission occurs at a one-off event where large numbers...
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News | 2019.09.06
Whooping cough: elucidation of a critical stage in the action of the CyaA toxin
Scientists from the Institut Pasteur are investigating CyaA, one of the major toxins of Bordetella pertussis. This bacterium is responsible for whooping cough, a disease that is currently on the rise. Acylation is a biochemical reaction in which an acyl chain is added to a molecule. It was already known that the CyaA protein was acylated in Bordetella pertussis. The scientists used a combination...
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News | 2023.01.16
A new stem cell model to study sex determination in humans
A stem cell model allows researchers to observe the earliest stages of sex determination in humans. This could help uncover why some people are born without a clearly identifiable sex at birth, as well as the development of future fertility treatments.