1. News | 2021.12.21

   New insights into the adaptation mechanisms of Leishmania parasites

   Parasites of the genus Leishmania show important genomic instability, which these pathogens use to adapt to their environment. A study by Institut Pasteur researchers shows that Leishmania exploits non-coding RNAs to mitigate toxic effects of genome instability by post-transcriptional regulation and the establishment of specialized ribosomes.

2. News | 2022.02.01

   CoronaFISH: a new method for studying SARS-CoV-2 and detecting its presence in the body

   The COVID-19 pandemic, which has afflicted the world for more than two years, is caused by SARS-CoV-2. The genome of this respiratory virus is composed of a single strand of RNA, a molecule similar to DNA that enables the virus to replicate in the body. Scientists from the Institut Pasteur, Inserm and the Paris Public Hospital Network (AP-HP) have developed a new method, CoronaFISH, to observe...

3. News | 2022.02.16

   Understanding resistance in HIV controller patients: how their antiviral CD4+ T cells are protected from infection

   Some rare HIV-infected patients are able to keep the viral load low enough not to require treatment. A study by researchers at the Pasteur Institute and collaborators shows that these patient CD4+ T cells block a receptor that is important for HIV entry.

4. News | 2022.06.14

   Cancer: observing immune cells fighting tumors

   An Institut Pasteur team has developed a microfluidic system to observe individual immune cells and model their interactions with tumors.

5. News | 2022.07.05

   Modeling: understanding how SARS-CoV-2 variants are selected

   Several factors determine the evolutionary success of SARS-CoV-2 variants of concern. A recent publication looks into the factors influencing this success – the number of people that an individual with the virus infects in turn, the timing of these infections and the contact rate –, using mathematical modeling to help understand the characteristics of these variants.

6. News | 2022.07.22

   Improving bacterial strain classification for more effective surveillance

   Genomic research on bacterial strains can provide the tools to develop a new classification system, leading to improved epidemiological surveillance, especially for antibiotic-resistant strains.

7. News | 2022.02.16

   COVID-19: reducing outbreak risk with repeated antigen screening in healthcare facilities

   With the emergence of the Omicron variant, healthcare facilities remain highly vulnerable to virus spread. Effective surveillance of viral presence in these facilities is therefore crucial and needs to be adapted according to outbreak risk. Scientists from the Institut Pasteur worked with colleagues to analyze the reactive use of antigen testing in a long-term care facility following a detected...

8. News | 2021.10.19

   A bacterium produces a contact-dependent antibiotic molecule

   Some strains of the bacterium Listeria monocytogenes are capable of producing an antibiotic molecule that enables them to kill other bacteria with which they come into direct contact.

9. Report | 2022.05.18

   Malaria and the globalization of disease

   This 18 May 2022 is the centenary of the death of Alphonse Laveran, winner of the Nobel Prize for Medicine and discoverer of the protozoan responsible for malaria, which has caused hundreds of millions of deaths around the world since the dawn of humanity. Few diseases have left such a lasting legacy on the history and lives of humans as malaria. This parasitic disease, which tends to follow a...

10. News | 2022.05.23

    Understanding the transmission of antibiotic resistance in Staphylococcus aureus

    To face the problem of antibiotic resistance, it is important to understand how bacterial strains develop competence to resist treatment. An international collaboration has identified how Staphylococcus aureus acquires resistance to a widely used antibiotic.

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