1. Article | 2020.06.22

   Drug Repurposing & Design to inhibit the SARS-CoV2 proteases

   Aim: Identification of antiviral molecules targeting SARS-CoV2 proteases. Structures of the proteases will be used to screen large chemical libraries in complement of the FDA approved drugs. High Througput Screening (HTS) using dual mCherry-Nanoluc reporter cell lines can screen thousands of compounds. Combined with virtual screening this allows coverage of a large chemical space including...

2. Article | 2020.06.22

   rBCG vaccine secreting SARS-CoV-2 antigens

   Aim: Mycobacterium bovis BCG is a live attenuated vaccine that is used since almost 100 years for the vaccination against tuberculosis, with a solid safety record in billions of immunocompetent individuals. The aim of the project is to construct recombinant BCG strains that express viral protein(s) of the SARS-CoV-2 virus in fusion with the 6 kD early secreted antigenic target (ESAT-6...

3. Article | 2020.06.22

   Investigating the role of apico-basal proteins during SARS-Cov2 infection

   Aim: Manipulation of the apico-basal Polarity pathways during infection is a strategy routinely used by numerous viruses. This leads to the mislocalization or degradation of the polarity proteins and participate to the disruption of the epithelial integrity.Nothing is known so far concerning SARS-CoV2 and polarity. In order to better understand SARS-CoV2 physiopathology, this study focuses...

4. News | 2020.06.22

   Neurodegenerative diseases: recycling mechanisms open up new avenues for therapy

   Alzheimer's and Parkinson's diseases are the most widespread forms of neurodegeneration in humans. Each year, 225,000 new cases of Alzheimer's disease are diagnosed in France, amounting to a total number of 900,000 patients in the country. This figure is expected to reach 2.1 million in 2040, representing a significant burden for public healthcare systems. So far, no efficient treatment options...

5. Article | 2020.06.22

   Fiche maladie redirect en Sars-CoV-2 / Covid-19

   Fiche maladie redirect en Sars-CoV-2 / Covid-19

6. Document de presse | 2020.06.23

   COVID-19 in primary schools: no significant transmission among children or from students to teachers

   In late April 2020, scientists at the Institut Pasteur, with the support of the Hauts-de-France Regional Health Agency and the Amiens Education Authority, carried out an epidemiological survey on 1,340 people linked to primary schools in Crépy-en-Valois, in the Oise department. Thanks to the cooperation of the people of Crépy-en-Valois, the survey, which made use of serological tests developed by...

7. News | 2020.06.24

   Genetic cause of difference in sexual development uncovered

   Researchers at the Francis Crick Institute, the Institut Pasteur and their clinical collaborators have identified a cause of testicular tissue developing in people with female chromosomes.“Differences in sexual development” (DSD) are genetic conditions in which there is a mismatch between the chromosomal sex, XY or XX, which are typically of males and females, and some aspect of their anatomy,...

8. News | 2020.07.03

   Existing drugs can prevent SARS-CoV-2 from hijacking cells

   Researchers evaluate how the new coronavirus rewires human proteins for its own replication, and identify several antiviral drugs ready for clinical trials.To sum up:An international team of researchers has analysed how SARS-CoV-2, the virus that causes COVID-19, hijacks the proteins in its target cells.The research shows how the virus shifts the cell’s activity to promote its own...

9. News | 2020.07.06

   Hepatitis B: natural controllers shed light on immunity mechanisms

   Infections in humans caused by the hepatitis B virus (HBV) represent a major public health problem. Despite the availability of effective protective vaccines, more than 250 million individuals worldwide are chronically infected according to WHO estimates. HBV infection is associated with cirrhosis, liver failure and hepatocellular carcinoma, responsible for approximately a million deaths every...

10. News | 2020.07.07

    Using medicinal chemistry to improve diagnostic methods

    Aptamers are DNA or RNA molecules that can bind with high affinity and/or specificity to target molecules. Given their properties, aptamers offer numerous advantages for diagnostic, biodetection and nanotechnology applications. However, aptamers being made of natural nucleic acids suffer from certain limitations. For instance, they are rapidly degraded when directly injected into patients, and...

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