Aim: Identification of antiviral molecules targeting SARS-CoV2 proteases. Structures of the proteases will be used to screen large chemical libraries in complement of the FDA approved drugs. High Througput Screening (HTS) using dual mCherry-Nanoluc reporter cell lines can screen thousands of compounds. Combined with virtual screening this allows coverage of a large chemical space including purchasable compounds libraries. The best hits will be further validated on SARS-CoV-2 growth assays. Validated hits will guide optimization of compounds.