1. Article | 2020.07.07

   Modeling human SARS-CoV-2 infection in mice with human lung xenografts

   To date there is no specific therapeutic treatment or vaccine for COVID-19 caused by the SARS-CoV-2 virus and relevant animal models that mimic human COVID-19 pathologies are lacking. We will generate two novel humanized mouse models: HuLung mice (human lung) and HIS-HuLung mice (and human immune system and human lung). Infection of HuLung and HIS-HuLung mice with SARS-CoV-2 will provide an in...

2. Article | 2020.07.07

   Neurological implications of SARS-COV-2 infection – a transversal study

   Aim: The infection of the nasal mucosa and the lungs by CoV-2 may spread to the CNS, including the brainstem, thereby playing a potential key role in the severe respiratory distress observed in COVID-19. Although several clinical observations support this hypothesis, the knowledge in this field is very limited. To fill this gap, we will investigate CoV-2 neuroinvasion in humans, animal models,...

3. Article | 2020.07.07

   Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection

   Aim: The PDZ-binding motifs of two viral proteins play an important role in virus replication and pathogenesis of SARS-CoV. Through in vitro and cellular high-throughput assays, this project aims to identify the cellular PDZ-containing proteins targeted by these two viral proteins during infection and to characterize the mechanism whereby the viral sequences compete with cellular PBM-PDZ...

4. Article | 2020.07.07

   Short Amplicon Based Sequencing Of SARS-CoV-2 for low-input samples

   Aim: Viral genomic is a key tool during outbreak response such as the SARS-CoV-2 emergence. However, sequencing can be challenging due to samples quality or low ratio of viral to host RNAs. This short technical project will implement and optimize a short amplicon-based approach tailored to SARS-CoV-2 and able to process low-quality and low-input clinical samples.

5. Article | 2020.07.07

   LuLISA project, bioluminescence as a tool for human diagnostics, from allergy to Covid19

   LuLISA project, bioluminescence as a tool for human diagnostics, from allergy to Covid19

6. Article | 2020.07.07

   CEPI collaborates with the Institut Pasteur in a consortium to develop Covid-19 vaccine

   CEPI collaborates with the Institut Pasteur in a consortium to develop Covid-19 vaccine

7. Article | 2020.07.07

   COVID-19: mathematical model indicates that between 3% and 7% of French people have been infected

   COVID-19: mathematical model indicates that between 3% and 7% of French people have been infected

8. Article | 2020.07.07

   COVID-19 - The Bioinformatics and Biostatistics Hub on the front line

   COVID-19 - The Bioinformatics and Biostatistics Hub on the front line

9. News | 2020.07.09

   Sleeping sickness: one step further in improving diagnosis

   The African trypanosome Trypanosoma brucei gambiense is a parasite responsible for chronic Human African Trypanosomiasis, more commonly known as sleeping sickness. Diagnosing sleeping sickness generally involves two stages: serological screening (to search for antibodies against parasites in the bloodstream), followed by the microscopic detection of live parasites in the blood or a lymph node...

10. Document de presse | 2020.07.06

    COVID-19: no cross-protective immunity conferred by other coronaviruses in children

    Every winter, seasonal coronaviruses are responsible for repeated colds and bronchitis from early childhood onwards. The question of whether the four seasonal coronaviruses can confer cross-protective immunity for COVID-19 was recently raised when it was demonstrated that some individuals had antibodies and immunity cells recognizing the SARS-CoV-2 virus before it was in active circulation. The...

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