1. Article | 2020.06.22

   Protocol for assessment of potential risk factors for 2019-novel coronavirus (2019-nCoV) infection among health care workers in a health care setting

   Aim: Worldwide, the health care workers play an essential role in the clinical management of Covid-19 patients, but in Africa they are also at risk of infection given the level of control measures in hospital wards. This study aims to obtain an early understanding of key epidemiological characteristics in the risk of transmission in healthcare workers in different African countries of the...

2. Article | 2020.06.22

   Developing a rapid diagnostic test to detect SARS-CoV2 virus in various environment

   Aim: The epidemy of the SARS-CoV-2 virus and its global spread urgently requires efficient means for rapid diagnosis, as well as detection in various environments (aside from clinical laboratories), such as airplanes, schools, potential animal carriers, etc. We have previously devised a colorimetric method to detect specific pathogen sequences using Rolling Circle Amplification (RCA) which...

3. Article | 2020.06.22

   Identification and isolation of potent human neutralizing antibodies against SARS-CoV-2

   Aim: Neutralizing antibodies (nAbs) hold great potential to prevent and treat SARS-CoV-2 infections. We propose to clone and express monoclonal antibodies (mAbs) from the IgG+ B cells of convalescent patients directed against SARS-CoV2 Spike (S) protein. Their neutralizing capacity will be tested by using pseudovirus particles and virus infection assays. Finally, the B-cell epitopes will be...

4. Article | 2020.06.22

   Accelerating the identification & design of SARS-CoV2 antiviral drugs in combination with the “DrugDesign_SARS2” project

   Aim: to accelerate the identification & design of SARS-CoV-2 antiviral drugs in combination with the “DrugDesign_SARS2” project. FDA-approved Institut Pasteur Paris platforms, and subsequently, wide libraries of purchasable compounds will be screened in silico to target functions/interactions of RNA_Pol, Spike (virus targets) and ACE2 (host targets) proteins. Prioritization will...

5. Article | 2020.06.22

   Urgent Discovery of Drug Candidates That Target Coronavirus SARS-CoV-2

   Aim: rapidly provide drug candidates to treat victims of Covid-19. We will do this by applying our cutting-edge technologies and libraries to screen for viable active compounds that kill coronavirus. The strategy will employ phenotype screens (FPDD) that test for coronavirus inhibition using mouse (MHV-59) and human (OC43) virus as models for fast compound screening in cell culture. Direct-...

6. Article | 2020.06.22

   Engineering an ACE2 derived polypeptide for label-free, real-time detection on a smartphone device and therapeutic intervention

   Aim: The current pandemic of CoV urges for therapeutic options and fast, and cheap diagnosis in alternative to the PCR based technology. We propose characterizing a newly designed polypeptide based on ACE2, which could be the base of detection devices adapted to smartphones and harbors the potential for therapeutic intervention. Focusing on ACE2 overcomes viral mutations, extending the...

7. Article | 2020.06.22

   Evaluation of SARS-CoV-2 infection spread in various populations groups in Cameroon

   Aim: The high case fatality ratio of Covid-19 compared to the flu is a global preoccupation. It could be related to non-reporting of mild and asymptomatic infection whose role in transmission is not completely clear if not diagnosed. It is therefore of paramount importance to quickly evaluate the true extent of the infection of SARS-CoV-2. We planned it in different population groups (close...

8. Article | 2020.06.22

   Development of novel nano-based multi-epitope vaccine against coronavirus SARS-CoV-2 - Generation of Humanized NSG transfer mouse model for vaccine testing

   Aim: We hypothesize that it may be possible to generate protective anti-SARS-CoV-2 immuneresponse in humanized NSG transfer mouse model. This will be achieved by administering to them of lipid-based nanoparticles carrying peptide molecules, comprising dominant immunogenic B and T cell epitopes from coronavirus SARS-CoV-2. The epitopes will be predicted by EpiDOCK server for evaluation of...

9. Article | 2020.06.22

   Investigation of the first cases of coronavirus (COVID-19) infections and their contacts in Antananarivo, Madagascar

   Aim: This study aims to understand the epidemiologic, clinical, virologic and immunologic characteristics of first infected cases, their evolution and household transmission. It is intended to follow confirmed infected cases and their household members. It will be conducted with clinicians from three hospital centers of Antananarivo.

10. Article | 2020.06.22

    Characterization of variable systemic and mucosal immunity during SARS-CoV-2 infection and recovery

    Aim: Our knowledge of the kinetics, intensity and diversity of cellular and humoral immune responses following SARS-CoV-2 infection in humans is limited. Using a novel technical pipeline based on the Milieu Interieur cohort approach, we will characterize systemic as well as local mucosal immunity during and after SARS-CoV-2 infection. We aim to identify immune signatures that can distinguish...

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