1. News | 2020.06.02

   The hidden population of multidrug-resistant Klebsiella bacteria colonizing the human digestive tract

   Klebsiella bacteria are responsible for some of the most antibiotic-resistant infections. A major study on intestinal colonization by Klebsiella has shed light on human carriage of these strains in the community (i.e. outside hospitals) in low-income countries. This study reveals that controlling Klebsiella carriage is a complex challenge.It is normal to find Klebsiella bacteria inhabiting the...

2. News | 2020.06.05

   Covid-19: a study in children with hyper-inflammatory syndrome related to Kawasaki disease

   The team of the Department of General Pediatrics and Infectious Diseases of the Necker-Enfants Malades AP-HP Hospital, the Institut Pasteur, Inserm and the University of Paris, conducted a prospective observational study between April 27 and May 15, 2020 to describe the characteristics of children and adolescents hospitalized in a context of Kawasaki disease-like syndrome in a COVID-19 epidemic...

3. News | 2020.06.04

   Study reveals conditions for the onset of severe forms of COVID-19

   Using state-of-the-art sequencing and bioinformatics techniques, scientists from the Institut Pasteur, working with fellow scientists from Israel and China, determined that patients with severe forms of COVID-19 presented an abnormal, ineffective lymphocyte response and a massive infiltration of inflammatory cells in the lungs.Patients with COVID-19 (see the COVID-19 fact sheet)present a...

4. News | 2020.06.10

   Small intestine regulates immune surveillance of colorectal cancer during chemotherapy treatment

   An international study has demonstrated that the microbiota and the intestinal cell death triggered by chemotherapy stimulate the efficacy of the immune response in patients with colorectal cancer. The results of the study, conducted in France by scientists from Gustave Roussy, Inserm, Université Paris-Saclay, the Institut Pasteur, IHU Méditerranée Infection and INRAE, were published in the...

5. Article | 2020.06.12

   Development of an animal model and accelerated development of a DNA vaccine candidate

   Aims:To develop a mouse model of SARS-CoV-2 infection.This will not only enable us to evaluate the efficacy of the vaccine; it will also facilitate in vivo research on SARS-CoV-2. To evaluate the immunogenicity (ability to induce a specific immune reaction) and efficacy (protection capability) of DNA-based vaccine candidates.DNA vaccination is a technique for protecting against...

6. Article | 2020.06.16

   Evolution of SARS-CoV-2 and the antibody immune response in humans during infection

   Aim: to understand the evolution of the SARS-CoV-2 viral population in hosts during illness, in relation with the infectivity of the virus and the establishment of the humoral (antibody-based) immune response. This knowledge is important to identify trends in disease progression and help improve the treatment and post-treatment follow-up given to patients. Detailed data on the evolution of...

7. Article | 2020.06.16

   Development of cell lines for research

   Aim: to generate a line of specific cells that will serve as a basis to improve characterization of the SARS-CoV-2 coronavirus. The generated cell lines will be useful in facilitating the isolation of clinical samples of coronavirus and in carrying out high-throughput screening     

8. Article | 2020.06.16

   A technique to identify key cellular factors for SARS-CoV-2 infection

   Aim: to carry out CRISPR/Cas9 tests to identify cellular factors involved in infection with SARS-CoV-2 and antiviral proteins that inhibit its replication. These approaches will lead to the identification of key cellular factors that may serve as virulence determinants and therapeutic targets.This research particularly concerns lung cells, the main targets of the virus. 

9. Article | 2020.06.16

   Building a collection of human biological samples in France

   Aim: to detect the presence of specific SARS-CoV-2 antibodies in different populations, either those who traveled to China in the weeks preceding the start of the outbreak, or those with suspected infection with SARS-CoV-2. The aim is to understand:When and how the virus was transmitted from animals to humansWhen the virus began circulating in humans in FranceHow long the infectious period...

10. Article | 2020.06.16

    Antibody profiling in recovering patients and development of a serological test for an epidemiological survey in individuals exposed to SARS-CoV-2

    Aim: to develop a test that can be used to carry out an initial survey on the prevalence of antibodies in individuals exposed to the SARS-CoV-2 coronavirus. The aim is to obtain a specific serological test that can be used for high-throughput testing for Covid-19 infection.

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