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Article | 2020.07.07
Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection
Aim: The PDZ-binding motifs of two viral proteins play an important role in virus replication and pathogenesis of SARS-CoV. Through in vitro and cellular high-throughput assays, this project aims to identify the cellular PDZ-containing proteins targeted by these two viral proteins during infection and to characterize the mechanism whereby the viral sequences compete with cellular PBM-PDZ...
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Article | 2020.07.07
Short Amplicon Based Sequencing Of SARS-CoV-2 for low-input samples
Aim: Viral genomic is a key tool during outbreak response such as the SARS-CoV-2 emergence. However, sequencing can be challenging due to samples quality or low ratio of viral to host RNAs. This short technical project will implement and optimize a short amplicon-based approach tailored to SARS-CoV-2 and able to process low-quality and low-input clinical samples.
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Article | 2020.07.07
LuLISA project, bioluminescence as a tool for human diagnostics, from allergy to Covid19
LuLISA project, bioluminescence as a tool for human diagnostics, from allergy to Covid19
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Article | 2020.07.07
CEPI collaborates with the Institut Pasteur in a consortium to develop Covid-19 vaccine
CEPI collaborates with the Institut Pasteur in a consortium to develop Covid-19 vaccine
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Article | 2020.07.07
COVID-19: mathematical model indicates that between 3% and 7% of French people have been infected
COVID-19: mathematical model indicates that between 3% and 7% of French people have been infected
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Article | 2020.07.07
COVID-19 - The Bioinformatics and Biostatistics Hub on the front line
COVID-19 - The Bioinformatics and Biostatistics Hub on the front line
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News | 2020.07.09
Sleeping sickness: one step further in improving diagnosis
The African trypanosome Trypanosoma brucei gambiense is a parasite responsible for chronic Human African Trypanosomiasis, more commonly known as sleeping sickness. Diagnosing sleeping sickness generally involves two stages: serological screening (to search for antibodies against parasites in the bloodstream), followed by the microscopic detection of live parasites in the blood or a lymph node...
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Document de presse | 2020.07.06
COVID-19: no cross-protective immunity conferred by other coronaviruses in children
Every winter, seasonal coronaviruses are responsible for repeated colds and bronchitis from early childhood onwards. The question of whether the four seasonal coronaviruses can confer cross-protective immunity for COVID-19 was recently raised when it was demonstrated that some individuals had antibodies and immunity cells recognizing the SARS-CoV-2 virus before it was in active circulation. The...
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Document de presse | 2020.07.15
Type 1 Interferon deficiency: A blood based Signature for Detecting Patients at risk of severe Covid-19 for a therapeutic approach
Which patients will develop a severe form of Covid-19? This is a key question that needs to be answered to improve the individual management and prognosis of patients. In a study published in Science on July 13, teams from AP-HP, Inserm, Université of Paris, Institut Pasteur and Institut Imagine describe a unique and unexpected immunological phenotype in severe and critical patients, consisting...
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News | 2020.07.24
Viral sequence integrated in mosquito genome controls infection by related virus
A new endogenous viral element (EVE) has been identified in Aedes aegypti mosquitoes. This EVE is almost identical to a contemporaneous strain of cell-fusing agent virus (CFAV), a widespread insect-specific virus found in Ae. aegypti populations. Researchers experimentally demonstrated that this EVE controls CFAV replication in the mosquito’s ovaries. This discovery supports the idea that EVEs...
