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Portrait | 2018.12.04
For Asier Sáez-Cirión, research is an incurable passion
It was 35 years ago that the HIV-1 virus, responsible for AIDS, was first isolated by scientists at the Institut Pasteur. While many lives have been saved by antiretroviral therapy, there is currently no treatment that fully eliminates the virus from the body, and the search for a vaccine goes on. These challenges are driving the research of a number of scientists at the Institut Pasteur,...
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News | 2019.10.25
Exhibition in honor of Jules Bordet at the Université libre de Bruxelles
On October 8, 2019, the Université libre de Bruxelles inaugurated an exhibition entitled "100th anniversary of a Nobel Prize – Jules Bordet". Developed in collaboration with the Institut Pasteur, this exhibition pays tribute to Institut Pasteur scientist Jules Bordet, who was awarded the 1919 Nobel Prize in Physiology or Medicine for his work on immunity. The exhibition will run until December 21...
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Document de presse | 2020.01.30
Institut Pasteur sequences the whole genome of the coronavirus, 2019-nCoV
On January 24, 2020, the French Ministry of Health confirmed the first three cases of patients affected by coronavirus, 2019-nCoV. On January 29, 2020, the Institut Pasteur, which is responsible for monitoring respiratory viruses in France, sequenced the whole genome of the coronavirus known as "2019-nCoV", becoming the first institution in Europe to sequence the virus since the start of the...
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News | 2020.02.14
Leishmaniasis: epigenetic mechanisms implicated in infection
Leishmaniasis is a human and animal disease caused by parasites of the Leishmania genus that affects 12 million people worldwide. It is endemic in around a hundred countries and is currently emerging in Europe as a result of climate change and large-scale population movements. Scientists from the Institut Pasteur in Paris, in collaboration with the Institut Pasteur of Shanghai-Chinese Academy of...
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Document de presse | 2020.06.23
COVID-19 in primary schools: no significant transmission among children or from students to teachers
In late April 2020, scientists at the Institut Pasteur, with the support of the Hauts-de-France Regional Health Agency and the Amiens Education Authority, carried out an epidemiological survey on 1,340 people linked to primary schools in Crépy-en-Valois, in the Oise department. Thanks to the cooperation of the people of Crépy-en-Valois, the survey, which made use of serological tests developed by...
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Document de presse | 2020.10.15
Innate immunity and fusion of cells infected with SARS-CoV-2
Innate immunity is the fastest-acting component of the immune system, but so far little is known about its role during infection with SARS-CoV-2. A few hours after an infection, the body emits an alarm signal, interferon, enabling cells that have not yet been infected to produce antiviral proteins. This phenomenon occurs well before the production of neutralizing antibodies. Scientists from the...
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Document de presse | 2020.10.08
AIDS: Furthering Knowledge of Natural HIV Infection Control Mechanisms
A further step has just been taken in understanding the mechanisms that allow some individuals to control HIV infection without treatment.A research team led by Dr. Asier Sáez-Cirión (Institut Pasteur) and Dr. Bruno Vaslin (IDMIT[1], CEA-Inserm-Université Paris Saclay) observed for the first time that the antiviral activity of CD8+ T cells of "controller" macaques infected with the simian...
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News | 2021.07.09
The Institut Pasteur International Network is evolving and becoming the Pasteur Network
A new system of governance is being introduced for the Institut Pasteur International Network and its 33 members, which since 2011 have been part of the Pasteur International Network association, which was chaired by the Institut Pasteur President Stewart Cole. Ten years on, the Network is adopting a more participatory, balanced mode of governance and a more structured business model. The...
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Document de presse | 2021.07.21
SARS-CoV-2 damages ciliated cells and inhibits mucociliary clearance in the airways
COVID-19 is a viral disease with respiratory symptoms that can induce fatal pneumonia. Understanding how SARS-CoV-2 spreads in the respiratory tract can help scientists identify the parameters controlling the severity of infection. Scientists from the Institut Pasteur, the CNRS and Inserm found that SARS-CoV-2 multiplies efficiently in the respiratory tract, and that it primarily targets ciliated...
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Document de presse | 2021.09.27
SARS-CoV-2: different immune responses observed in nasal mucosa and blood
The clinical manifestations of SARS-CoV-2 infection vary from one individual to the next, and much remains unknown about the mechanisms underpinning this variability. Since the nasal mucosa is one of the first entry points of the virus, scientists from the Institut Pasteur and Inserm, in collaboration with Cochin AP-HP Hospital, analyzed in parallel the immune responses in the nasal mucosa and in...