Course

Human population genomics and genetic epidemiology

Epidemiology and Public Health
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This two-week course presents theoretical lectures, research examples and hands-on computer training on concepts and tools used in the study of human population genomics and genetic epidemiology.

Practical information

Institut Pasteur
October 8-19, 2018
June 15, 2018
In English

Diplomas

Credits for a Master 2 degree Paris Descartes
Credits for a Master 2 degree Sorbonne Université
Credits for a Master 2 degree Paris Diderot
Doctoral School Module
Institut Pasteur Diploma

The first week consists in three days of both theoretical lectures and research examples, and two days of hands-on-computer training and discussions presenting the concepts and the technical tools used in both human population genomics and genetic epidemiology.

Topics include:

  • Introductory concepts in human genomics and populations genetics.
  • Basic concepts in statistical genetics and genomics.
  • Introduction to genetic epidemiology.
  • Population genetics: mutation, recombination and linkage disequilibrium.
  • Public databases in human genomics (HapMap, 1,000 Genomes).
  • Genetic epidemiology (linkage analyses and association studies).
  • Methods to detect natural selection in the human genome.
  • Research examples.
  • Lectures from keynote speakers in genetic epidemiology and population genetics.

The second week consists in two days of detailed theoretical bases in population genomics and genetic epidemiology analyses and three days of practical computer-based training in the most recent concepts and analyses used in both disciplines. The practical training (computer laboratory work and discussion of the results) is based on real-data examples, using infectious diseases as a paradigm.

Topics include :

  • Quantitative genetics and expression quantitative trait loci (eQTL) analysis.
  • Analysis of rare variants and population structure.
  • Next Generation Data – design and analysis.
  • Genome-wide association analyses (GWAS) – exomes – whole genome sequencing – transcriptomics - RNA seq.
  • Computer laboratory work in genetic epidemiology.
  • Computer laboratory work in population genetics.
  • Lectures from keynote speakers.
     

    Candidates must have basic knowledge in molecular genetics, statistics and informatics.

    The course committee will evaluate applications.


    Human population genomics and genetic epidemiology Flyer - Course 2018

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More informations

Director(s)

Lluis Quintana-Murci

Human Evolutionary Genetics Unit

Institut Pasteur

 

Alexandre Alcais

Human Genetics of Infectious Diseases

INSERM U. 980

Necker Medical School

 

HONORARY DIRECTOR

Laurent Abel

Human Genetics of Infectious Diseases

INSERM U. 980

Necker Medical School

Attendees
25
Duration
Two weeks
Members of the Course committee

L. Abel (Inserm-Necker)

A. Alcais (Inserm-Necker),

S. Garnier (Université Pierre et Marie Curie),

M. Lucas-Hourani (Institut Pasteur),

S. Lyonnet (Université Paris-Descartes),

V. Ponticelli (Institut Pasteur),

L. Quintana-Murci (Institut Pasteur),

S. Malot (Institut Pasteur),

M. Sala (Institut Pasteur),

H. Waxin (Institut Pasteur),

A. Zider (Université Paris-Diderot).

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