The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
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This five-week intensive laboratory and lecture course presents advanced studies on the main themes in cellular and molecular immunology.
The course comprises :
- LABORATORY PRACTICAL COURSE: Three weeks (full time)
Monitoring human immune responses
Immuno-monitoring is nowadays performed through a variety of molecular and cellular approaches, involving an array of cutting-edge technologies. This is key for human translational medicine studies on infectious diseases, epidemic outbreaks, vaccine trials, vaccination follow up, etc.
The goal of this practical course is to introduce students to investigate a research subject through a variety of state of the art experimental approaches, and to sensitize them to translational medicine studies.
Taking advantage of the New Institut Pasteur Center for Translational Medicine and the Milieu Intérieur Laboratory of Excellence Consortium, this practical course will focus on the characterization of age-dependent differences in the immune response of healthy individuals, in the presence or absence of chronic cytomegalovirus (CMV) infection. The response of each individual to an array of immune stimuli, targeting innate or adaptive immunity, will be investigated by immunophenotyping whole human blood samples and peripheral blood mononuclear cells (PBMC). A battery of approaches will be used, including multi-color flow cytometry, imaging flow cytometry, real-time PCR, RNA-sequencing, simple and multiplex ELISA. In addition, a subset of immune cells will be sorted and analyzed for the influence of immune stimulation on their metabolic activity. The students will have access to cutting-edge technologies available at the Technology Cores of the Center for Translational Medicine (CRT technology Cores) of the Institut Pasteur.
Sponsors: We thank the LabEx Milieu Intérieur for financial support and Becton Dickinson for lending us a FACS analyzer.
- LECTURES: two weeks (full time). Lectures will be dealing with advanced studies on major topics in cellular and molecular immunology, such as: development of the immune system, lymphocyte differentiation, molecular basis of antigen recognition by B and T lymphocytes, repertoire selection, lymphocyte homeostasis, tolerance, cellular communication, immune responses, innate immunity and various aspects of immunopathology. Lectures are given by internationally renowned speakers.
- BIBLIOGRAPHY ANALYSIS SEMINARS : three days of bibliography analysis, on six main immunology subjects will be, given by groups of students and supervised by two senior scientists per subject. These seminars aim at training students to the analysis and public presentation of a scientific work. These seminars are mandatory for students enrolled in Master programs and optional for other participants.
The program of the course organized the previous year can be downloaded to get detailed information on the general frame of the course; some topics and practical works may change each year, without altering the general aims and means of the course.
1) Since Type-2 Biosafety laboratory facilities will be used during the course, updated tetanos and hepatitis B vaccination certificates are required for all the students.
2) The course requires the students’ personal work during evenings and weekends. Students are asked not to take any engagements in that period of time. For instance, MDs or Pharmacists are asked to get no hospital duties during the period of the course, including during the bibliography seminars week.
3) Candidates must have a good knowledge in Immunology (1st year master level, or equivalent), Biochemistry, Molecular Biology and Genetics.
4) Students should have good knowledge of Englishlanguage to be able to understand full lectures, ask questions and deliver the bibliography analysis seminar in English. Understanding of French language is useful, but not mandatory, for daily interactions.
5) Students not enrolled in a master 2 program of a partner Parisian university will finish the course on December 18th, 2015. Master 2 students will have the final exam on January 5th 2016 (estimate date).
6) Bibliography seminars will be run from January 6th to January 8th-2016.
The committee of the course will evaluate applications.
Members of the Teaching Committee :
A. Alcover (Institut Pasteur),
E. Coeffier (Institut Pasteur),
A. Cumano (Institut Pasteur),
M. Hasan (Institut Pasteur),
E. Tartour* (Université Paris-Descartes),
M. Sala (Institut Pasteur),
A. Six* (Université P. et M. Curie),
M. Viguier* (Université Paris-Diderot),
H. Waxin (Institut Pasteur),
A. Zider* (Université Paris-Diderot).
* University Representatives
Title of the course
Lymphocyte cell biology unit - Institut Pasteur
Lymphopoiesis Unit - Institut Pasteur
Head of studies
Center for Human Immunology - Institut Pasteur
5 +1 weeks
November 16th, to December 18th, 2015 and January 5th to 8th, 2016
Closing date for application
June 15, 2015
Institut Pasteur Diploma
Diplôme d'Université (DU) from Paris Diderot University for people registering at this university (registration fees ≈ €250).
Credits for a Masters degree for students registered at Parisian partner universities.
Attending conferences can be validated as a "module d'école doctorale (doctoral school module)" for students registered at partner universities.