Advanced immunology

This five-week intensive laboratory and lecture course presents advanced studies on the main themes in cellular and molecular immunology.


The main course comprises:


- Three weeks of state of the art practical laboratory sessions designed to introduce students to a research subject investigated by a variety of experimental approaches. Focus is on the characterization of two functions of the AID protein (Activation Induced Cytidine Deaminase) in B cells: isotypic switch and somatic hypermutation.

These roles of AID will be studied in B cells from wild type or AID-KO mice by FACS, ELISA analyses, reporter gene transfection assays, siRNA silencing, sequencing genes undergoing somatic hypermutation and real-time PCR. Some experiments are carried out in the BSL2+ facility of the Institut Pasteur Center for Human Immunology (CIH).


- Two weeks of lectures dealing with advanced studies on major topics in cellular and molecular immunology, such as: development of the immune system, lymphocyte differentiation, molecular basis of antigen recognition by B and T lymphocytes, repertoire selection, lymphocyte homeostasis, tolerance, cellular communication, immune responses, innate immunity and various aspects of immunopathology.


- Three days of thematic bibliography analysis seminars, given early January by groups of students and supervised by two senior scientists. These seminars are mandatory for students enrolled in Masters programs and optional for other participants.


The program of the course organized the previous year can be downloaded to get detailed information on the general content of the course; some topics and practical works may change each year, without altering the general aims and means of the course.


Program of the 2013-2014 Advanced immunology course  (PDF - 400 KB)


Important Information

1) Since Type-2 Biosafety laboratory facilities will be used during the course, students’ updated tetanos and hepatitis B vaccination certificates are required.


2) The course requires personal work during evenings and weekends. Students should not make other commitments during that period. For instance, no hospital duties should be undertaken by MDs or Pharmacists during the course, including during the bibliography seminar week.


3) Candidates must have a good knowledge in biochemistry, molecular biology and genetics, as well as a good first year Masters level in immunology (or equivalent).


4) Students should have good knowledge of English to be able to understand full lectures, ask questions and deliver the bibliography analysis seminar in English. An understanding of French is useful, but not mandatory, for daily interactions.


5) Students not enrolled in a master 2 program of a partner university will take the final exam and finish the course on Saturday December 6th, 2014. Master 2 students will and take the final exam from January 5th to January 9th, 2015.


The course committee will evaluate applications.


Members of the Teaching Committee:


A. Alcover (Institut Pasteur),

P. A. Cazenave (Institut Pasteur/Université P. et M. Curie),

E. Coeffier (Institut Pasteur),

A. Freitas (Institut Pasteur),

C. Fridman* (Université Paris-Descartes),

F. Huetz (Institut Pasteur),

M. Sala (Institut Pasteur),

H. Waxin (Institut Pasteur),

A. Six* (Université P. et M. Curie),

M. Viguier* (Université Paris-Diderot),

A. Zider (Université Paris-Diderot).


* University Representatives


Practical information


Title of the course

Advanced immunology


Andres Alcover

Lymphocyte cell biology unit - Institut Pasteur


Antonio Freitas

Lymphocyte population biology unit - Institut Pasteur

Head of studies

François Huetz

Lymphocyte population biology unit - Institut Pasteur






5 +1 weeks


November 17th, 2014 to December 19th, 2014 and January 5th to 9th, 2015

Closing date for application

June 15, 2014


Institut Pasteur Diploma


Diplôme d'Université (DU) from Paris Diderot University for people registering at this university (registration fees ≈ €250).


Credits for a Masters degree for students registered at Parisian partner universities.


Attending conferences can be validated as a "module d'école doctorale (doctoral school module)" for students registered at partner universities.



On line registration

Registration fees


Updated on 08/01/2015

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