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Document de presse | 2019.11.12
Gut microbiota imbalance promotes the onset of colorectal cancer
The gastroenterology team at Henri-Mondor AP-HP Hospital and University Paris-Est Créteil, led by Professor Iradj Sobhani, together with teams from Inserm and the Institut Pasteur Molecular Microbial Pathogenesis Unit (U1202), led by Professor Philippe Sansonetti – holder of the Microbiology and Infectious Diseases Chair at the Collège de France –, have demonstrated that an imbalance in the gut...
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Document de presse | 2019.12.12
Gastric cancer susceptibility marker discovered
Gastric cancer, the third most common cause of cancer-related deaths, is often associated with a poor prognosis because it tends to be diagnosed at an advanced stage and is therefore difficult to treat. To reduce the death rate, it is essential to identify a biomarker enabling early diagnosis of this cancer. In pursuit of this goal, scientists from the Institut Pasteur, CNRS, and University of...
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News | 2020.07.09
Sleeping sickness: one step further in improving diagnosis
The African trypanosome Trypanosoma brucei gambiense is a parasite responsible for chronic Human African Trypanosomiasis, more commonly known as sleeping sickness. Diagnosing sleeping sickness generally involves two stages: serological screening (to search for antibodies against parasites in the bloodstream), followed by the microscopic detection of live parasites in the blood or a lymph node...
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Document de presse | 2020.10.08
AIDS: Furthering Knowledge of Natural HIV Infection Control Mechanisms
A further step has just been taken in understanding the mechanisms that allow some individuals to control HIV infection without treatment.A research team led by Dr. Asier Sáez-Cirión (Institut Pasteur) and Dr. Bruno Vaslin (IDMIT[1], CEA-Inserm-Université Paris Saclay) observed for the first time that the antiviral activity of CD8+ T cells of "controller" macaques infected with the simian...
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Document de presse | 2021.03.07
COVID-19: neutralizing immune response lasts longer in women than in men
As part of the SEROCoV-HUS study, teams from Strasbourg University Hospital and the Institut Pasteur monitored 308 hospital staff who had previously contracted a mild form of SARS-CoV-2. The scientists demonstrated that neutralizing antibodies could be detected in 84% of them up to 6 months after infection, but that the level fell more quickly in men than in women. These results seem to suggest...
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News | 2021.03.09
Whooping cough: light shed on the entry mechanism of a key Bordetella pertussis virulence factor
Bordetella pertussis is the agent responsible for whooping cough, a disease that is currently on the rise. In particular, the bacterium produces the CyaA toxin. A consortium including several teams from the Institut Pasteur, CNRS, and Sorbonne University, working closely with the C2RT Proteins Pole technical cores and several SOLEIL and ESRF synchrotron light lines, has examined the entry...
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Document de presse | 2021.04.21
SARS-CoV-2: infection induces antibodies capable of killing infected cells regardless of disease severity
Drawing on epidemiological field studies and the FrenchCOVID hospital cohort coordinated by Inserm, teams from the Institut Pasteur, the CNRS and the Vaccine Research Institute (VRI, Inserm/University Paris-Est Créteil) studied the antibodies induced in individuals with asymptomatic or symptomatic SARS-CoV-2 infection. The scientists demonstrated that infection induces polyfunctional antibodies....
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News | 2021.07.09
The Institut Pasteur International Network is evolving and becoming the Pasteur Network
A new system of governance is being introduced for the Institut Pasteur International Network and its 33 members, which since 2011 have been part of the Pasteur International Network association, which was chaired by the Institut Pasteur President Stewart Cole. Ten years on, the Network is adopting a more participatory, balanced mode of governance and a more structured business model. The...
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News | 2021.07.15
BCG vaccine: the first tuberculosis vaccination took place a century ago
July 2021 marks the hundredth anniversary of the first vaccination of an infant with the BCG vaccine. Although tuberculosis is still one of the ten leading causes of mortality worldwide, this vaccine, developed at the Institut Pasteur, led to a steep reduction in the number of cases. We take a look back at how the vaccine was discovered.Albert Calmette arrived in Lille in 1897 as director of the...
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News | 2021.12.14
2022: the bicentenary of Louis Pasteur's birth
Louis Pasteur was born on December 27, 1822. He was an international figure in scientific and medical research and the founder of the Institut Pasteur (Paris) in 1887. Louis Pasteur was a precursor of a certain way of conducting research, deeply concerned with its goals, both humanistic and universal, and the need to train and transmit this approach and these values to future generations. Today,...