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News | 2018.06.05
An update on Ebola in the Democratic Republic of the Congo with Arnaud Fontanet, an expert at the Institut Pasteur
For several weeks, the Democratic Republic of the Congo has been facing a new outbreak of the hemorrhagic fever Ebola. Where does this virus come from? What is the latest on the current crisis? An update with Arnaud Fontanet, Professor at the CNAM and Head of the Epidemiology of Emerging Diseases Unit at the Institut Pasteur in Paris. Arnaud Fontanet, Professor at the CNAM and Head of...
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Document de presse | 2019.02.18
Gene therapy durably reverses congenital deafness in mice
In collaboration with the universities of Miami, Columbia and San Francisco, scientists from the Institut Pasteur, Inserm, CNRS, Collège de France, Sorbonne University and the University of Clermont Auvergne have managed to restore hearing in an adult mouse model of DFNB9 deafness – a hearing disorder that represents one of the most frequent cases of congenital genetic deafness. Individuals with...
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News | 2019.11.07
Parkinson's: new discoveries about nanotubes, transporters of toxic proteins
We now know that neurodegenerative diseases are caused by the aggregation of "misfolded" proteins in the brain. These proteins, which are toxic for neurons, spread from cell to cell through tiny tunnels, known as nanotubes. After imaging their structure in detail, (1) scientists in the Institut Pasteur's Membrane Traffic and Pathogenesis Unit, directed by Chiara Zurzolo, are now investigating the...
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Document de presse | 2021.03.26
COVID-19: analysis of the sensitivity of the UK (B.1.1.7) and South African (B.1.351) variants to SARS-CoV-2 neutralizing antibodies
The B.1.1.7 and B.1.351 variants of SARS-CoV-2 were first detected in the UK and South Africa respectively, and have since spread to many other countries. Scientists from the Institut Pasteur joined forces with Orléans Regional Hospital, Tours University Hospital, Créteil Intercommunal Hospital, Strasbourg University Hospital and Georges Pompidou European Hospital to study the sensitivity of...
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Document de presse | 2021.04.06
Light shed on the coordination of neural stem cell activation
In all adult vertebrates, neural stem cells can be recruited to produce new neurons in the brain. However, little is known about these so-called "activation" processes. Scientists at the Institut Pasteur, CNRS, and Tel Aviv University working in collaboration with the École Polytechnique and INRAE have successfully performed 3D visualization and spatial and temporal distribution analysis of...
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Document de presse | 2021.04.14
Genetic admixture in the South Pacific: from Denisovans to the human immune response
Describing the genetic diversity of human populations is essential to improve our understanding of human diseases and their geographical distribution. However, the vast majority of genetic studies have been focused on populations of European ancestry, which represent only 16% of the global population. Scientists at the Institut Pasteur, Collège de France, and CNRS have looked at understudied...
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Document de presse | 2021.05.05
COVID-19: discovery of the mechanisms of short- and long-term anosmia
Loss of smell, or anosmia, is one of the earliest and most commonly reported symptoms of COVID-19. But the mechanisms involved had yet to be clarified. Scientists from the Institut Pasteur, the CNRS, Inserm, Université de Paris and the Paris Public Hospital Network (AP-HP) determined the mechanisms involved in the loss of smell in patients infected with SARS-CoV-2 at different stages of the...
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Portrait | 2022.03.29
Jean-Claude Manuguerra: viruses, animals and humans
It all started with a veterinarian and a cross-eyed lionJean-Claude Manuguerra was 7 when he decided that he wanted to become a veterinarian, to "save animals" – like in the TV series Daktari, which he was an avid fan of at the time. In the series, Dr. Marsh Tracy was a vet who cared for local animals and ran the Wameru Study Center for Animal Behavior in Kenya. Marsh Tracy was aided in his day-...
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Document de presse | 2022.07.13
Light shed on SARS-CoV-2 replication in bat cells
Bats are reservoir species for numerous viruses including coronaviruses. Given that they do not appear to be affected by diseases transmitted by these viruses, there is potential benefit in understanding how their immune system regulates infection. Scientists at the Institut Pasteur and the CNRS studied SARS-CoV-2 replication in bat cells, which involved using real-time imaging techniques for the...
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News | 2023.09.19
HIV-AIDS : inspiring patients
With early and rigorous treatment, some so-called "controller" patients are able to keep their viral load low enough to not suffer from AIDS. These are inspiring cases for research, not to mention the very rare patients who have already been completely cured of HIV.