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News | 2019.11.08
Gut microbiota: surprising interactions between pathogenic and commensal bacteria
In achieving a state of equilibrium in the body, the billions of microbes that form assemblies known as microbiota at various sites including the gut, the skin and the oral cavity play an important role. The absence of microbiota results in increased exposure to some diseases. Scientists from the Bacteria-Cell Interactions Unit at the Institut Pasteur, in collaboration with INRA, Inserm...
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News | 2019.12.11
Anticipating and reacting quickly to outbreaks: a consortium won the Galien MedStartUp award
The Praesens Foundation, the Institut Pasteur, the Institut Pasteur de Dakar, University of Nebraska Medical Center and Twist Bioscience Corporation (NASDAQ: TWST) announced that the consortium is the winner of the Prix Galien MedStartUp award in the category: 'Best Collaboration Dedicated to the Developing or Underserved Populations Worldwide'. The consortium works together to...
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News | 2021.03.09
Whooping cough: light shed on the entry mechanism of a key Bordetella pertussis virulence factor
Bordetella pertussis is the agent responsible for whooping cough, a disease that is currently on the rise. In particular, the bacterium produces the CyaA toxin. A consortium including several teams from the Institut Pasteur, CNRS, and Sorbonne University, working closely with the C2RT Proteins Pole technical cores and several SOLEIL and ESRF synchrotron light lines, has examined the entry...
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News | 2021.10.15
The Institut Pasteur de Guinée: a young institute in the midst of the COVID-19 crisis
The decision to set up an Institut Pasteur in Guinea was made in 2014 in response to the Ebola crisis. It reflects the joint determination of France and Guinea to tackle emerging outbreaks on a long-term basis for the welfare of the population. When the COVID-19 pandemic struck, how was this young institute able to fulfill its remit as a front-line laboratory?When the first case of COVID-19 was...
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Document de presse | 2021.10.26
The intranasal lentiviral vaccine candidate (Lenti-S) protects brain and lung in a pre-clinical animal model
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, primarily targets the respiratory tract, but its ability to infect cells of the nervous system has also been largely reported. Indeed, the expression of the receptor of this virus, the Angiotensin Converting Enzyme 2 (ACE2), by neuronal and glial cells makes the brain susceptible to SARS-CoV-2. Moreover, neurological manifestations are...
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Document de presse | 2021.09.27
SARS-CoV-2: different immune responses observed in nasal mucosa and blood
The clinical manifestations of SARS-CoV-2 infection vary from one individual to the next, and much remains unknown about the mechanisms underpinning this variability. Since the nasal mucosa is one of the first entry points of the virus, scientists from the Institut Pasteur and Inserm, in collaboration with Cochin AP-HP Hospital, analyzed in parallel the immune responses in the nasal mucosa and in...
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Article | 2022.03.29
PPU-Research & Technology Program
The PPU-Research & Technology Program gives access to a stimulating technological environment to carry out PhD student’s research project. This includes opportunities to conduct technological and methodological co-developments on high-end equipment under the supervision/in partnership with technology platforms or service and research units (UTechS). In addition, students of the PPU-Research...
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News | 2022.08.24
ZIKAlliance project: Zika vector competence data reveals risks of outbreaks
A publication published this summer looks back at the contribution of the European ZIKAlliance project, launched in 2016 following the Zika epidemic in the Pacific Islands and America. A global analysis of the competence of potential vectors was carried out, the most comprehensive study of vector competence to date using the same protocols. This study reminds us that vector-borne diseases are...
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Document de presse | 2022.12.20
Identification of a new neural pathway essential for refining odor perception
In the brain, sensory messages are processed by neurons that send the information collected by the sensory organ to the different structures of the brain. At each stage of integration, the activity of these neurons is controlled by interneurons that exert local inhibition in order to direct and modulate the neural messages. This type of circuit forms the classical architecture of the sensory...
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News | 2023.11.16
Antibiotic resistance, or how bacteria become resistant
Antibiotic resistance is a major public health issue. Understanding how resistance works and how bacteria become resistant is crucial in helping us maintain the effectiveness of antibiotics against bacteria.