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News | 2020.03.19
Discovery of numerous potential open reading frames in the Cryptococcus genome
Gene structure, including the transcript leader, is very diverse in fungi. New sequencing data analysis from the RNA Biology of Fungal Pathogens unit revealed that in the pathogenic yeasts Cryptococcus, the transcript leader sequence are rich in potential upstream Open Reading Frames, which regulate both gene expression and protein diversity.Pathogenic Cryptococcus species are responsible for...
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Article | 2020.03.27
Coronavirus (Covid-19) research projects
VACCINE CANDIDATES1. Development of an animal model and accelerated development of a DNA vaccine candidate(SCARD SARS-CoV-2 project)Aims:To develop a mouse model of SARS-CoV-2 infection.This will not only enable us to evaluate the efficacy of the vaccine; it will also facilitate in vivo research on SARS-CoV-2. To evaluate the immunogenicity (ability to induce a specific immune reaction) and...
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News | 2020.04.15
COVID-19 - The Bioinformatics and Biostatistics Hub on the front line
Like many other research teams at the Institut Pasteur, the Bioinformatics and Biostatistics Hub is engaged in fighting against the COVID-19 pandemic by participating in the curation of GISAID data (Global Initiative on Sharing All Influenza Data). The Hub is the service division of the Computational Biology Department, and is composed of 50 experts in biostatistics and bioinformatics.At the end...
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Document de presse | 2020.05.07
Achilles’ heel for reseeding of the viral reservoir after stem cell transplantation in people with HIV
Current HIV treatments efficiently block viral multiplication but cannot cure infection as they do not target HIV infected cells. HIV cure or profound HIV remission have been described in three persons with HIV who underwent allogeneic stem cell transplantation to treat severe blood cancers. However, this procedure has not eradicated the virus in other persons. A work led by scientists from the...
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News | 2020.05.14
LuLISA project, bioluminescence as a tool for human diagnostics, from allergy to Covid19
The LuLISA (Luciferase-Linked ImmunoSorbent Assay) research project aims developing high throughput serological tests for epidemiological studies at local, regional or nation scales. In a recent scientific publication, concerning the detection and dosing of IgE specific to several allergens in patients’ blood samples, the use of LuLISA proves to be a vastly improved detection method in...
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Document de presse | 2020.05.26
COVID-19: the vast majority of patients with a minor form develop neutralizing antibodies
Teams from Strasbourg University Hospital and the Institut Pasteur carried out a study among hospital staff on the two sites of Strasbourg University Hospital. After observing 160 people with minor forms of COVID-19, the scientists concluded that nearly all the patients developed antibodies within two weeks of being infected. In 98% of the patients, neutralizing antibodies were detected after 28...
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Article | 2020.06.16
Evolution of SARS-CoV-2 and the antibody immune response in humans during infection
Aim: to understand the evolution of the SARS-CoV-2 viral population in hosts during illness, in relation with the infectivity of the virus and the establishment of the humoral (antibody-based) immune response. This knowledge is important to identify trends in disease progression and help improve the treatment and post-treatment follow-up given to patients. Detailed data on the evolution of...
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Article | 2020.06.22
Developing a rapid diagnostic test to detect SARS-CoV2 virus in various environment
Aim: The epidemy of the SARS-CoV-2 virus and its global spread urgently requires efficient means for rapid diagnosis, as well as detection in various environments (aside from clinical laboratories), such as airplanes, schools, potential animal carriers, etc. We have previously devised a colorimetric method to detect specific pathogen sequences using Rolling Circle Amplification (RCA) which...
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News | 2020.07.27
A new biotechnology tool to tackle antibiotic resistance
Designing effective new molecules to tackle infectious diseases is a difficult process that currently represents a huge challenge for scientists, especially given the rise in bacterial resistance to antibiotics. Scientists from the Institut Pasteur's Bacterial Genome Plasticity Unit have responded to this challenge by developing a new biotechnological tool which bypasses the sampling limitations...
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News | 2020.08.04
Malaria: parasite resistance to artemisinin now found in Africa
Resistance to artemisinin, the main component of current antimalarial treatments recommended by WHO, is widespread in South-East Asia, but has not been described in Africa. In a study published in 2020, scientists from the Institut Pasteur, in collaboration with the NMCP in Rwanda, the WHO and Columbia University provided for the first time evidence of the de novo emergence of Pfkelch13-mediated...