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News | 2016.05.11
The Institut Pasteur signs Framework-Agreement with the Centre National d’Etude Spatiale
On Monday 9th Mai, 2016 on the Institut Pasteur campus, the President of the Institut Pasteur, Christian Bréchot and the President of the French space agency (CNES), Jean-Yves Le Gall signed a 5-year Framework Agreement.
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News | 2016.05.17
HIV: Identification of key immune response receptors in patients spontaneously controlling infection
A small number of patients infected by HIV spontaneously control viral replication without antiretroviral therapy, and do not develop the disease. The ability of these rare patients, known as "HIV controllers", to suppress HIV replication appears to be down to a highly effective immune response. Scientists observed that CD4+ T immune cells in these patients were capable of recognizing...
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News | 2016.06.05
Identification of a therapeutic compound for a genetic form of autism spectrum disorders thanks to high throughput screening
A team of researchers has highlighted the therapeutic potential of lithium in a patient with a rare form of autism spectrum disorder associated with SHANK3 gene mutation. This molecule, usually used to treat bipolar disorder, was identified thanks to high throughput screening of chemical compounds on human neurons derived from pluripotent stem cells, including those of the treated patient.
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News | 2016.06.22
Malaria - First global mapping of artemisinin resistance confirms definitively that resistance is confined to Southeast Asia and has not spread to sub-Saharan Africa
The first global mapping of artemisinin resistance (the KARMA study) has definitively confirmed that resistance to the main drug currently used in the treatment of Plasmodium falciparum malaria is for the moment confined to Southeast Asia and has not spread to sub–Saharan Africa.
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News | 2016.06.22
Antibodies that are effective against both dengue and Zika viruses
Scientists have identified antibodies that can efficiently neutralize both the dengue virus and the Zika virus. The description of the binding site for these antibodies on the viral envelope, identical for both viruses, could lead to the development of a universal vaccine that offers simultaneous protection against dengue and Zika virus disease.
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News | 2016.06.29
The relentless dynamism of the adult brain
Scientists were able to make real-time observations over a period of several months that reveal how new adult-born neurons are formed and evolve in the olfactory bulb of mice. They made the surprising discovery that there is constant structural plasticity in the connections established by these new neurons with the circuits into which they are recruited.
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News | 2016.07.06
Phage therapy: fundamental action mechanisms revealed
Scientists identify for the first time the genetic and metabolic mechanisms underpinning the therapeutic action of a bacteriophage known for its therapeutic potential. Given the worrying rise in bacterial resistance to antibiotics and the difficulties in developing effective new molecules, there has been renewed interest within the scientific community in recent years in phage therapy, which...
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News | 2016.07.17
Malaria: a genetically attenuated parasite induces an effective, long-lasting immune response
With nearly 3.2 billion people currently at risk of contracting malaria, scientists from the Institut Pasteur, the CNRS and Inserm have experimentally developed a live, genetically attenuated vaccine for Plasmodium, the parasite responsible for the disease. By identifying and deleting one of the parasite's genes, the scientists enabled it to induce an effective, long-lasting immune response...
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News | 2016.08.21
Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes
Scientists from the Institut Pasteur have demonstrated the role of lysosomal vesicles in transporting α-synuclein aggregates, responsible for Parkinson's and other neurodegenerative diseases, between neurons. These proteins move from one neuron to the next in lysosomal vesicles which travel along the "tunneling nanotubes" between cells.
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News | 2016.08.22
TONIRA : towards better medical care of acute respiratory infections among children in Niger
In Niger, respiratory infections and pneumonia are the second cause of hospital infant mortality (10 to 20% of deaths according to health authorities information). As in most African countries, few data on surveillance and etiology of these infections are available whereas they are essential to guide public health policies. In addition in Niger, antibiotic treatment for acute respiratory diseases...
