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Document de presse | 2013.09.30
Potential therapeutic targets for blocking AIDS virus replication
Scientists from the Institut Pasteur and Inserm have identified several proteins in humans as potential new therapeutic targets for treating the AIDS virus. These proteins are part of a complex cellular mechanism that blocks the virus replication in cells called macrophages. The discovery of this mechanism and the proteins involved gives scientists a solid theoretical basis for developing new...
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Document de presse | 2013.10.09
Fine-tuning the approach to malaria and toxoplasmosis research
A study carried out by teams from the Institut Pasteur, the Institut Cochin (Inserm, CNRS, Paris Descartes University), and the Wellcome Trust Centre for Molecular Parasitology at the University of Glasgow, may very well redefine current approaches to malaria and toxoplasmosis research in terms of treatment development. Their research which focuses on the role played by the protein AMA1 (present...
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Document de presse | 2013.11.03
Identification of a new mechanism in immunotherapy for lymphoma
Using innovative dynamic imaging technique, scientists at the Institut Pasteur, Inserm and the VU Medical Center in Amsterdam have uncovered the mode of action of anti-CD20, an antibody therapy frequently used in the treatment of lymphomas (cancers of the immune system) as well as some auto-immune diseases. In a lymphoma model, the scientists have been able to carry out real time in vivo imaging...
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Document de presse | 2013.11.27
Clinical trial launched to treat Sanfilippo B syndrome using gene therapy
A phase I/II gene therapy clinical trial for children suffering from Sanfilippo B syndrome, a rare genetic disease, enrolled a first patient in October of this year. The trial is being carried out and coordinated by the Institut Pasteur (the trial’s sponsor), Inserm, AFM-Téléthon and Vaincre les Maladies Lysosomales (VML). It is being conducted at Bicêtre Hospital (AP-HP) in Paris. If the...
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Document de presse | 2013.11.04
Two European programs reinforce the fight against emerging diseases
The 31 partners involved in the two major European research programs PREDEMICS and ANTIGONE are to meet for a joint seminar at the Institut Pasteur on November 6th. These two programs will respectively receive €11.7 million and €12 million funding of the European Union over five years to study the emergence mechanisms of infectious diseases in order to strengthen existing treatment and...
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Document de presse | 2013.12.11
Carriers of a genetic mutation show increased dependence on tobacco
Scientists at the Institut Pasteur, the French National Center for Scientific Research (CNRS) and Pierre and Marie Curie University (UPMC) have recently proven that, in mice, nicotine intake – nicotine is the main addictive substance in tobacco – is heavily regulated by a genetic mutation that is very common in humans. This mutation affects the neuronal nicotinic receptor, disrupting...
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Document de presse | 2013.12.12
A prime target for the development of anti-inflammatories
For the first time, scientists from the Institut Pasteur and Inserm have demonstrated the key role played by a particular molecule in intestinal infection. The study was published online in Immunity on December 12, 2013. The molecule, known as ATP, serves as a trigger signal for the inflammatory response targeting pathogenic agents. Using the Shigella flexneri model, the scientists have also...
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Fiche maladie | 2016.06.21
Zika
The Zika virus is a Flavivirus mainly transmitted by the bite of infected mosquitoes of the genus Aedes. It causes Zika virus disease.
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Fiche maladie | 2015.10.06
MERS-CoV
A new respiratory virus emerged in Saudi Arabia in 2012. It was named MERS-CoV, or Middle East Respiratory Syndrome Coronavirus, and it affects the respiratory tract, causing fever and a cough and proving fatal in 30% of cases. The virus has since been reported in several countries throughout the Middle East. In all, 1,219 cases have been diagnosed, leading to 449 deaths. Several cases have been...
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Fiche maladie | 2015.10.06
Sepsis / Septicemia
Sepsis is the term used internationally to describe a widespread inflammatory response that occurs as a result of severe infection. Septicemia, the term coined in 1837 by French doctor Pierre Piorry from the Greek words "σήψις" (sêptikós), putrefaction, and "αίμα" (haîma), blood, refers to the presence of bacteria (or fungi or viruses) in the blood. Sepsis primarily affects people with weak...
