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Article | 2022.03.29
Strategic and scientific partnership with Université Paris Cité
The Institut Pasteur is a research partner organization, member of Université Paris Cité community. The Institut Pasteur’s association with Université Paris Cité is a global partnership for research and education in the field of biology and health, formally established in June 2021.
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Document de presse | 2022.03.25
Towards more effective treatments for immunocompromised patients
For severely immunocompromised patients, a bone marrow transplant restores immune defenses and allows them to resume normal life. But after observing the nasopharyngeal mucosa, one of the body's first lines of immune defense, scientists from the Institut Pasteur, Université Paris Cité, Inserm and the Paris Public Hospital Network (AP-HP), in collaboration with the Imagine Institute, demonstrated...
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Document de presse | 2022.03.29
SARS-CoV-2: neutralization of BA.1 and BA.2 by therapeutic monoclonal antibodies
The SARS-CoV-2 Omicron BA.1 sublineage has been supplanted in many countries by the BA.2 sublineage. Although Omicron is responsible for less severe forms in the general population, immunocompromised people are still at higher risk of developing severe forms of COVID-19. Several monoclonal antibodies are currently available in clinical practice as a preventive treatment for these patients....
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Document de presse | 2022.04.13
Colon cancer: how mutation of the APC gene disrupts lymphocyte migration
In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers from the Institut Pasteur, INSERM(1) and Université Paris Cité describe the mechanisms that modify the structure of T lymphocytes and hinder their migration towards...
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Document de presse | 2022.04.20
When severe infection causes long-term mood disorders: A promising avenue to prevent mental illness following a transient infection
The brain is able to detect and regulate localized or systemic inflammation by using two communication pathways. The first, humoral, makes use of specific brain structures that enable circulating inflammatory mediators to enter the brain. The second, neural, involves nerves whose sensory afferents transmit the inflammatory signal detected at local level. The vagus nerve therefore uses identified...
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Document de presse | 2022.04.12
HIV: The Antibodies of "Post-treatment Controllers"
A very small percentage of people with HIV-1, known as "post-treatment controllers" (PTCs), are able to control their infection after interrupting all antiretroviral therapy.Understanding the fundamental mechanisms that govern their immune response is essential in order to develop HIV-1 vaccines, novel therapeutic strategies to achieve remission, or both.A recent study investigated the humoral...
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News | 2022.04.14
Monoclonal antibody SPK001: potent and broad neutralization activity across all SARS-CoV-2 variants of concern
SPK001, the monoclonal antibody developed by SpikImm, a biotech company founded by the Institut Pasteur and Truffle Capital, has demonstrated a potent and broad neutralization activity across all SARS-CoV-2 variants of concern, including omicron (BA.1 and BA.2). Originally developed in the Humoral Immunology lab headed by Dr Hugo Mouquet at the Institut Pasteur (joint research unit Inserm),...
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Document de presse | 2022.04.14
Decoding a direct dialog between the gut microbiota and the brain
Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions. Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and adapt appetite and...
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Document de presse | 2022.04.14
How bacteria evade bacteriophages in vivo
Phage therapy, which uses viruses known as bacteriophages to treat bacterial infections, is a long-standing medical procedure whose mechanisms of action are still poorly understood. Scientists from the Institut Pasteur and CNRS have demonstrated in vivo in a murine model that bacteria are capable of regulating their gene expression to evade the numerous bacteriophages present in the gut...
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Article | 2022.04.21
Calmette & Yersin Grants
Calmette & Yersin is a grants programme created to finance trainings for students, researchers and technicians for long and short studies or research programs. Created in 2010 by the Department of International Affairs of the Institut Pasteur, the Pasteur Network Foundation resumes the funding for internships, trainings and doctoral and post-doctoral programes to be carried out at one of...
