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Document de presse | 2022.02.17
Legionellosis: a novel mechanism by which the bacterium Legionella pneumophila regulates the immune response of its host cells
Legionellosis or Legionnaires’ disease affected more than 1 800 people in France in 2019 and caused 160 deaths. This emerging disease is caused by Legionella pneumophila, an environmental bacterium that thrives in hot water systems. Researchers from the Institut Pasteur, the CNRS, the University of Paris have discovered a mechanism that allows Legionella pneumophila to target the immune response...
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Document de presse | 2022.02.21
Transplantation chemotherapy eliminates regenerative capacity of brain’s innate immune cells
Annually over 50,000 bone marrow transplantations occur worldwide as a therapy for multiple cancerous and non-cancerous diseases. Yet, how this procedure gives rise to bone marrow-derived cells that engraft the brain, despite being absent in the normal brain, remains unknown. In the present study, scientists from the Institut Pasteur, the CNRS and the Paris Brain Institute (Inserm) discovered how...
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Document de presse | 2022.02.21
Death of Professor François Gros, on February 18, 2022
It was with very great sadness that the Institut Pasteur learned of the death of François Gros, Professor at the Institut Pasteur and Director of Research at the CNRS, on February 18, 2022.François Gros, President of the Institut Pasteur between 1976 and 1981, made a major contribution to the discovery of messenger RNA and protein synthesis initiation factors, remarkable scientific achievements...
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Document de presse | 2022.02.25
Discovery of an innate immunological memory in the intestine
The innate immune system plays a crucial role in regulating host-microbe interactions, and especially in providing protection against pathogens that invade the mucosa. Using an intestinal infection model, scientists from the Institut Pasteur and Inserm discovered that innate effector cells – group 3 innate lymphoid cells – act not only during the early stages of infection but can also be trained...
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News | 2022.02.28
Signing of an exclusive license agreement between the Institut Pasteur and Meletios Therapeutics for the development of a new class of antivirals
The exclusive worldwide license agreement signed between the Institut Pasteur and Meletios Therapeutics, a French biotechnology company specializing in the research and development of next-generation antiviral therapies, concerned a technology platform for the generation of Defective Viral Genomes (DVG). DVGs are truncated or rearranged copies of a virus, making these viral sequences non-...
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Document de presse | 2022.03.04
The Institut Pasteur stands in solidarity with Ukraine and its scientific community
The Institut Pasteur voices support for the people and scientific community of Ukraine in response to the military invasion of their country by Russia.Since the start of the conflict, the Institut Pasteur has launched various initiatives to help Ukrainian academics. The institute has also stepped forward to host Ukrainian researchers as part of France's PAUSE program (national program for the...
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Document de presse | 2022.03.14
Discovery of an immune escape mechanism promoting Listeria infection of the central nervous system
Some "hypervirulent" strains of Listeria monocytogenes have a greater capacity to infect the central nervous system. Scientists from the Institut Pasteur, Université Paris Cité, Inserm and the Paris Public Hospital Network (AP-HP) have discovered a mechanism that enables cells infected with Listeria monocytogenes to escape immune responses. This mechanism provides infected cells circulating in...
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News | 2022.03.23
Admixture, an adaptation mechanism for populations exposed to pathogens
In a new study, scientists from the Institut Pasteur and the CNRS demonstrate that admixture, a pervasive phenomenon in recent millennia, has enabled human populations to exchange beneficial genetic mutations among themselves, thereby facilitating their adaptation, especially when confronted with infectious diseases.
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Article | 2022.03.29
PPU-Research & Technology Program
The PPU-Research & Technology Program gives access to a stimulating technological environment to carry out PhD student’s research project. This includes opportunities to conduct technological and methodological co-developments on high-end equipment under the supervision/in partnership with technology platforms or service and research units (UTechS). In addition, students of the PPU-Research...
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Portrait | 2022.03.29
Jean-Claude Manuguerra: viruses, animals and humans
It all started with a veterinarian and a cross-eyed lionJean-Claude Manuguerra was 7 when he decided that he wanted to become a veterinarian, to "save animals" – like in the TV series Daktari, which he was an avid fan of at the time. In the series, Dr. Marsh Tracy was a vet who cared for local animals and ran the Wameru Study Center for Animal Behavior in Kenya. Marsh Tracy was aided in his day-...
