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Document de presse | 2022.03.29
SARS-CoV-2: neutralization of BA.1 and BA.2 by therapeutic monoclonal antibodies
The SARS-CoV-2 Omicron BA.1 sublineage has been supplanted in many countries by the BA.2 sublineage. Although Omicron is responsible for less severe forms in the general population, immunocompromised people are still at higher risk of developing severe forms of COVID-19. Several monoclonal antibodies are currently available in clinical practice as a preventive treatment for these patients....
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Document de presse | 2022.04.13
Colon cancer: how mutation of the APC gene disrupts lymphocyte migration
In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers from the Institut Pasteur, INSERM(1) and Université Paris Cité describe the mechanisms that modify the structure of T lymphocytes and hinder their migration towards...
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Document de presse | 2022.04.20
When severe infection causes long-term mood disorders: A promising avenue to prevent mental illness following a transient infection
The brain is able to detect and regulate localized or systemic inflammation by using two communication pathways. The first, humoral, makes use of specific brain structures that enable circulating inflammatory mediators to enter the brain. The second, neural, involves nerves whose sensory afferents transmit the inflammatory signal detected at local level. The vagus nerve therefore uses identified...
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Document de presse | 2022.04.12
HIV: The Antibodies of "Post-treatment Controllers"
A very small percentage of people with HIV-1, known as "post-treatment controllers" (PTCs), are able to control their infection after interrupting all antiretroviral therapy.Understanding the fundamental mechanisms that govern their immune response is essential in order to develop HIV-1 vaccines, novel therapeutic strategies to achieve remission, or both.A recent study investigated the humoral...
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News | 2022.04.14
Monoclonal antibody SPK001: potent and broad neutralization activity across all SARS-CoV-2 variants of concern
SPK001, the monoclonal antibody developed by SpikImm, a biotech company founded by the Institut Pasteur and Truffle Capital, has demonstrated a potent and broad neutralization activity across all SARS-CoV-2 variants of concern, including omicron (BA.1 and BA.2). Originally developed in the Humoral Immunology lab headed by Dr Hugo Mouquet at the Institut Pasteur (joint research unit Inserm),...
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Document de presse | 2022.04.14
Decoding a direct dialog between the gut microbiota and the brain
Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions. Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and adapt appetite and...
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Document de presse | 2022.04.14
How bacteria evade bacteriophages in vivo
Phage therapy, which uses viruses known as bacteriophages to treat bacterial infections, is a long-standing medical procedure whose mechanisms of action are still poorly understood. Scientists from the Institut Pasteur and CNRS have demonstrated in vivo in a murine model that bacteria are capable of regulating their gene expression to evade the numerous bacteriophages present in the gut...
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Document de presse | 2022.05.04
HIV: bestowing CD8+ T cells with properties observed in natural controllers
HIV controllers are rare individuals able to control infection naturally without treatment. CD8+ T immune cells play a critical role for these individuals, suppressing viral load in the long term even without antiretroviral therapy. Scientists at the Institut Pasteur are examining key characteristics of these controllers' CD8+ T cells, with a view to replicating them in other individuals who are...
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Document de presse | 2022.05.03
Development of an ensemble model to anticipate short-term COVID-19 hospital demand
For the past two years, the COVID-19 pandemic has exerted pressure on the hospital system, with consequences for patients' care pathways. To support hospital planning strategies, it is important to anticipate COVID-19 health care demand and to continue to improve predictive models.In this study published in the journal PNAS, scientists from the Mathematical Modeling of Infectious Diseases Unit at...
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Document de presse | 2022.05.11
Hepatitis: 3D structure determination of the ‘gateway’ to the liver
Scientists from CNRS, the Institut Pasteur (France), the Vlaams Instituut voor Biotechnologie and the Vrije Universiteit Brussel (Belgium) have published a ground-breaking study of the structure and function of a central protein in the liver: NTCP, a cellular-entry pathway for bile salts, but also for certain hepatitis viruses. Published in the journal Nature, these results reveal the 3D...
