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Article | 2019.09.13
The use of animals in the Institut Pasteur's research programs
In the pursuit of its mission to prevent and combat diseases in France and throughout the world, the Institut Pasteur operates in four main areas: scientific and medical research, public health and health monitoring, education, and development of research applications.
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News | 2016.10.17
Esrrb transcription factor plays a key role in maintaining stem cell identity even after countless divisions
How is it that embryonic stem cells are able to divide over and over again without ever losing their identity? Scientists from the Institut Pasteur have recently answered this question with their discovery that a transcription factor, Esrrb, is directly involved in controlling the transfer of information that enables stem cells to continue expressing the same genes as the initial stem cell even...
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Document de presse | 2019.10.22
A blood factor involved in weight loss and aging
Aging is a process that affects all functions of the human body, particularly brain function. However, aging can be delayed through lifestyle changes (physical exercise, restricting calorie intake, etc.). Researchers at the Institut Pasteur and CNRS have elucidated the properties of a molecule in the blood – GDF11 – whose mechanisms were previously unknown. In a mouse model, they showed that this...
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Document de presse | 2023.12.06
Plasmodium vivax malaria: infections may be largely underestimated in sub-Saharan Africa
Researchers from the Institut de Parasitologie et de Pathologie Tropicale at the University of Strasbourg and the Laboratoire de Parasitologie et de Mycologie Médicale at the Strasbourg University Hospital, in collaboration with King's College London, UK, the Institut Pasteur (Paris, France), the Institut Pasteur de Madagascar and the University of Addis Ababa, Ethiopia, have revealed how...
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News | 2020.07.06
Hepatitis B: natural controllers shed light on immunity mechanisms
Infections in humans caused by the hepatitis B virus (HBV) represent a major public health problem. Despite the availability of effective protective vaccines, more than 250 million individuals worldwide are chronically infected according to WHO estimates. HBV infection is associated with cirrhosis, liver failure and hepatocellular carcinoma, responsible for approximately a million deaths every...
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Document de presse | 2014.01.23
A new bacterial mechanism for evading the immune system
A team of scientists from the Institut Pasteur, the CNRS and Paris Diderot University has identified a new regulation mechanism that enables a pathogenic bacterium of the Streptococcus genus to rapidly adapt to its host. This study was published on January 16, 2014 in PLoS Pathogens. The mechanism in question enables the bacterium to minimize its exposure to the immune system while maintaining...
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Document de presse | 2006.06.05
AIDS: discovery of a new mechanism induced by HIV to modulate the immune system
Researchers from the Pasteur Institute and the CNRS* have revealed a novel mechanism utilized by the AIDS virus (HIV) to modulate the host immune response. They have shown that the virus substantially reduces contacts between the HIV-1 infected T lymphocytes and other cells of the immune system. These cells contacts are crucial to the triggering of adequate immune response. Their work is...
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News | 2019.07.23
Shedding light on almost indestructible archaeal pili
Extremophiles are organisms that have evolved to thrive under extremely harsh environmental conditions. Scientists have always been mystified by how these organisms survive in such settings and especially how extracellular appendages, such as pili, remain stable. Researchers from the Institut Pasteur, in collaboration with colleagues from the University of Virginia revealed how sugars make those...
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News | 2021.01.25
Covid-19: impacts of the pandemic on the human microbiome
The Covid-19 epidemic has had great impact on people’s lives across the world. The disease, physical distancing and lockdown measures have had multiple effects on health. One less-studied effect is the consequence on the microbiome. A group of prominent microbiome researchers in biomedical and social science, coordinated by Brett Finlay (University of British Columbia) and Tamara Giles-Vernick (...
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News | 2016.08.25
A new approach for deciphering complex immune responses
The response to infection is highly variable from one individual to another. The Milieu Intérieur consortium, coordinated by Prof. Matthew Albert (Immunobiology of dendritic cells Unit, Institut Pasteur / Inserm) and Dr Lluis Quintana-Murci (Human Evolutionary Genetics Unit, Institut Pasteur / CNRS) seeks to establish the parameters that characterize the immune system of healthy individuals and...