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Document de presse | 2016.06.23
Antibodies that are effective against both dengue and Zika viruses
Scientists from the Institut Pasteur and the CNRS[1], in collaboration with Imperial College London and the University of Vienna, Austria, have identified antibodies that can efficiently neutralize both the dengue virus and the Zika virus. The description of the binding site for these antibodies on the viral envelope, identical for both viruses, could lead to the development of a universal...
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News | 2020.12.02
Diphtheria: identification of a penicillin resistance gene
Before the vaccine era, diphtheria was the most deadly respiratory infection in young children. There are still outbreaks of diphtheria in some world regions and cases can occur among unvaccinated individuals, with severe consequences. Antibiotics are vital in treating diphtheria, and the emergence of antibiotic resistance is a major public health concern. A team of Institut Pasteur scientists...
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Document de presse | 2022.06.20
How to improve the care of childhood encephalitis in South-East Asia
Encephalitis is an acute inflammation of the brain tissue that affects children and adults, especially in South-East Asia. Researchers and physicians involved in the "South-East Asia encephalitis" (SEAe) project, coordinated by the Institut Pasteur in collaboration with the Pasteur Network, have demonstrated the importance of prevention as well as rapid and appropriate diagnosis and treatment of...
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News | 2024.09.18
Whooping cough: how do we explain its resurgence in 2024 in France?
In a study coordinated by the Institut Pasteur, scientists describe the dynamics of the whooping cough epidemic in 2024 in France, the worst in 25 years. The scientists also sequenced the genome of almost 70 bacterial isolates collected during the outbreak from January to mid-2024. These analyses allowed them to put forward several theories explaining the current resurgence in circulation of the...
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Document de presse | 2008.02.14
Chikungunya: an animal model, at last !
Researchers from the Institut Pasteur and INSERM have developed the first mouse model for chikungunya virus infection. This animal model mimics both the benign and severe forms of the disease. As a result, the scientists have determined which tissues and cells are infected by the virus in each of these clinical conditions. The development of such an animal model is a major advance, not only at...
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Document de presse | 2019.07.11
High-risk pregnancy: the interferon effect
Discovery of a cellular mechanism involved in abnormal placental development during some high-risk pregnancies.High-risk pregnancies occur frequently and may be caused by various factors. It is estimated that 10 to 20% of pregnant women miscarry during their first trimester of pregnancy. Slow fetal growth may also arise as a result of maternal infection with certain microbes, parasites or viruses...
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Document de presse | 2022.04.12
HIV: The Antibodies of "Post-treatment Controllers"
A very small percentage of people with HIV-1, known as "post-treatment controllers" (PTCs), are able to control their infection after interrupting all antiretroviral therapy.Understanding the fundamental mechanisms that govern their immune response is essential in order to develop HIV-1 vaccines, novel therapeutic strategies to achieve remission, or both.A recent study investigated the humoral...
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Document de presse | 2023.01.25
Discovery of a circovirus involved in human hepatitis
Scientists from the Institut Pasteur, Necker-Enfants Malades Hospital (AP-HP), Inserm in the Imagine Institute, Université Paris Cité and the Alfort National Veterinary School (EnvA) have identified a previously unknown species of circovirus, provisionally named human circovirus 1 (HCirV-1). Circoviruses are a family of small, highly resistant DNA viruses that were initially identified in 1974 in...
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Document de presse | 2022.03.29
SARS-CoV-2: neutralization of BA.1 and BA.2 by therapeutic monoclonal antibodies
The SARS-CoV-2 Omicron BA.1 sublineage has been supplanted in many countries by the BA.2 sublineage. Although Omicron is responsible for less severe forms in the general population, immunocompromised people are still at higher risk of developing severe forms of COVID-19. Several monoclonal antibodies are currently available in clinical practice as a preventive treatment for these patients....
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Document de presse | 2013.05.05
Chikungunya : discovery of a human-specific factor involved in the virus replication
Scientists from the Institut Pasteur, Inserm and CNRS, have identified a human-specific factor involved in the replication of Chikungunya virus which accounts for the species specificity of this virus. Chikungunya virus is an emerging virus that in 2005 caused, for the first time, an outbreak in La Réunion island, a French overseas district where more than 30% of the population was infected, and...