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Document de presse | 2011.09.12
The first human model for neurodegenerative Sanfilippo syndrome
Researchers from the Institut Pasteur and Inserm, in collaboration with the Centre de Biologie Cellulaire in Lyon, have obtained the first human neuron model for Sanfilippo syndrome, an incurable neurodegenerative disorder that occurs in children. This model is the tool of choice for studying the cellular mechanisms at the root of this disease as well as for identifying therapeutic options....
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Document de presse | 2011.05.15
Graft rejection at the cellular level filmed in 3D
Using a new and original in vivo imaging technique enabling real-time, in-depth, cellular immune response mechanism investigation in animals, researchers from the Institut Pasteur and Inserm have been the first to observe the process of graft rejection. Observing this "cellular choreography" has most notably proven the existence of a mechanism that contributes to the immune reaction...
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Document de presse | 2011.03.31
AREVA Foundation and Institut Pasteur sign a new partnership agreement for Aids research
AREVA Foundation continues to fight Aids alongside the Institut Pasteur in 2011. Two new Institute teams will benefit from the continuing partnership: • the team led by Professor Olivier Schwartz, who directs the Virus and Immunity Research Unit • the team of Dr. Michaela Müller of the Retroviral Infection Regulation Unit directed by Professor Barré-Sinoussi, Nobel Prize in Medicine....
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Document de presse | 2011.01.19
3D structure leads to first decoding of mechanism of action of general anesthetics
Two teams from the Institut Pasteur in association with the French National Center for Scientific Research (CNRS) have published in the journal Nature the three-dimensional structure of two general anesthetics bound to their membrane receptor. This research provides the first atomic-resolution structures of general anesthetics which can be used to understand their action mechanism, a mechanism...
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Document de presse | 2011.01.02
Hepatitis C : in 2011, a predictive marker for response to therapy
Scientists at Inserm and Institut Pasteur have performed biomarker discovery on patients being treated for chronic hepatitis C infection. Their work, published in The Journal of Clinical Investigation, demonstrates that the plasma levels of the protein IP-10 predict, prior to treatment initiation, the efficacy of treatment with pegylated-interferon and ribavirin. Based on these results, the...
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Document de presse | 2010.11.16
Stem cells and genetic programming : lessons from fundamental research
Scientists at the Institute Pasteur and CNRS have identified key regulatory factors controlling one of the critical developmental processes occurring during embryo development : X-inactivation, which ensures the silencing of the genes carried by one of the two X chromosomes present in all cells of female mammals. These regulatory factors are also implicated in maintaining the capacity...
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Document de presse | 2010.10.04
Malaria: a theory disproved – the parasite can develop and persist in the skin
Scientists from the Institut Pasteur have demonstrated in rodents that, contrary to long-held belief, the malaria parasite is able to develop and produce infectious forms not only in the liver but also in the skin. This discovery proves that the skin is not merely a transitional site for the parasites on their way to the liver, but a site where the parasites can actually develop and even persist...
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Document de presse | 2010.01.18
The life and death of neurons: how a virus can control everything
Researchers at the Institut Pasteur and the French National Center for Scientific Research (CNRS) have just discovered that the rabies virus expresses in one of its proteins a key region which enables the human neurons that it infects to survive, and this is an essential condition for the virus to spread in the organism. By identifying the mechanisms which regulate whether the neuron survives or...
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Document de presse | 2009.06.10
A major breakthrough in understanding the virulence of the Listeria bacterium in humans
A study carried out by Institut Pasteur researchers in cooperation with Inserm and INRA reveals how Listeria monocytogenes, the bacterium responsible for listeriosis, changes the activity of its entire genome to shift from an inoffensive to a pathogenic state. New types of gene products (RNAs) have been discovered. This research, which appeared in the advanced online edition of the journal Nature...
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Document de presse | 2009.05.26
The Institut Pasteur and the U.S. CDC sign a Memorandum of Understanding to promote global public health
The Institut Pasteur and the U.S. Centers for Disease Control and Prevention (CDC) signed a Memorandum of Understanding on the occasion of the Assembly of the World Health Organization (WHO), in Geneva, last week. The agreement unites the efforts of these two organizations – both leaders in the field of global public health – by creating a framework for shared and lasting actions to...