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Document de presse | 2011.05.15
Graft rejection at the cellular level filmed in 3D
Using a new and original in vivo imaging technique enabling real-time, in-depth, cellular immune response mechanism investigation in animals, researchers from the Institut Pasteur and Inserm have been the first to observe the process of graft rejection. Observing this "cellular choreography" has most notably proven the existence of a mechanism that contributes to the immune reaction...
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Document de presse | 2013.11.03
Identification of a new mechanism in immunotherapy for lymphoma
Using innovative dynamic imaging technique, scientists at the Institut Pasteur, Inserm and the VU Medical Center in Amsterdam have uncovered the mode of action of anti-CD20, an antibody therapy frequently used in the treatment of lymphomas (cancers of the immune system) as well as some auto-immune diseases. In a lymphoma model, the scientists have been able to carry out real time in vivo imaging...
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News | 2022.08.24
ILC3s: "gatekeeper" cells for intestinal immunity
The intestinal mucosa is a key site for interaction and exchange with the external environment. It is therefore under constant surveillance from the immune system. Using an animal model, scientists from the Institut Pasteur and Inserm discovered how a set of cells involved in innate immunity – group 3 innate lymphoid cells – help monitor and maintain this barrier.Our digestive tract contains...
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News | 2022.06.14
Cancer: observing immune cells fighting tumors
An Institut Pasteur team has developed a microfluidic system to observe individual immune cells and model their interactions with tumors.
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News | 2021.03.30
Cancer: CAR T cell function scrutinized to improve immunotherapy
Immunotherapy, or the notion of "retraining" patients' immune systems, constitutes a major step forward in the fight against cancer. Although the results of CAR T cell therapy are very positive, its efficacy is still difficult to predict. Research by scientists at the Institut Pasteur has improved our understanding of how these cells function. One immunotherapy strategy involves genetically...
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Article | 2025.01.20
Immunology
The complexity of the immune system is a never-ending source of fascination for scientists. The Department of Immunology is composed of teams that investigate the body's natural system of protection against disease.
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Article | 2019.08.06
Vaccinology and Immunotherapy Initiative: Fundamental Research
Many different fields of the highly recognized fundamental research pursued at the Institut Pasteur are connected to vaccinology or immunotherapy. These include pathogen identification and characterization, structural analysis, in silico approaches, analysis of mechanisms to potentially enhance antigen immunogenicity and/or delivery or to identify specific immunotherapy targets, effects of...
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Article | 2019.06.25
Host-pathogen interactions (33 entities)
Pathogens have evolved sophisticated strategies to infect, propagate and persist within their hosts. Here, host-pathogen interactions are studied at the molecular, cellular, organ and whole-organism levels. The long-term goal of these studies is to identify novel targets for diagnosis, vaccination and treatment.
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Document de presse | 2013.03.17
Buruli Ulcer: Mechanism Behind Tissue Erosion Revealed
Scientists at the Pasteur Institute in Paris and the CNRS (French National Center for Scientific Research), in collaboration with the Universities of Basel (Switzerland) and Cambridge (UK) have identified the mechanism underlying the formation of Buruli ulcers caused by the bacterium Mycobacterium ulcerans. Their discovery opens avenues for the development of novel therapeutic approaches for...
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Article | 2019.06.20
New diagnostic approaches and innovative therapies
Developing innovative therapeutic approaches to improve treatment of patients and provide a rapid and permanent cure.