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Document de presse | 2021.10.26
The intranasal lentiviral vaccine candidate (Lenti-S) protects brain and lung in a pre-clinical animal model
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, primarily targets the respiratory tract, but its ability to infect cells of the nervous system has also been largely reported. Indeed, the expression of the receptor of this virus, the Angiotensin Converting Enzyme 2 (ACE2), by neuronal and glial cells makes the brain susceptible to SARS-CoV-2. Moreover, neurological manifestations are...
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News | 2021.10.15
The Institut Pasteur de Guinée: a young institute in the midst of the COVID-19 crisis
The decision to set up an Institut Pasteur in Guinea was made in 2014 in response to the Ebola crisis. It reflects the joint determination of France and Guinea to tackle emerging outbreaks on a long-term basis for the welfare of the population. When the COVID-19 pandemic struck, how was this young institute able to fulfill its remit as a front-line laboratory?When the first case of COVID-19 was...
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News | 2021.09.30
DIM ELICIT Symposium on Wednesday, October 20, 2021 at IPGG: registrations are open!
The DIM ELICIT (Empowering LIfe sCiences with Innovative Technologies) is organizing its closing event on Wednesday, October 20, 2021 at the Pierre-Gilles-de-Gennes Institute for Microfluidics (IPGG). The program will highlight the most emblematic projects of the DIM ELICIT with interventions in the form of pairs (biologist/technologist). This will be also an opportunity to exchange with the...
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Document de presse | 2021.09.27
SARS-CoV-2: different immune responses observed in nasal mucosa and blood
The clinical manifestations of SARS-CoV-2 infection vary from one individual to the next, and much remains unknown about the mechanisms underpinning this variability. Since the nasal mucosa is one of the first entry points of the virus, scientists from the Institut Pasteur and Inserm, in collaboration with Cochin AP-HP Hospital, analyzed in parallel the immune responses in the nasal mucosa and in...
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News | 2021.09.09
SPKM001, a promising anti-SARS-CoV-2 monoclonal antibody, is being developed by the Institut Pasteur and SpikImm
Following encouraging initial results, which will be published shortly, the Institut Pasteur and SpikImm announce the development of the antibody SPKM001.Paris, September 9, 2021SPKM001 is a high affinity human monoclonal antibody which targets the receptor-binding site (RBD) on the Spike protein of the original SARS-CoV-2 strain and its variants.Initial preclinical results tend to show that this...
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Document de presse | 2021.08.26
COVID-19: Will telecommuting strategies stop the virus from circulating?
How can we best organise on-site workplace and school attendance periods and remote work to slow the circulation of Sars-CoV-2? Is it better to separate classes? Bring your whole team in at the same time? Set this up on daily or weekly schedules? The COVID-19 pandemic has forced most countries to impose contact limitations in workplaces, universities and schools. Scientists from the CNRS,...
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Article | 2021.08.03
Neuro-inflammation and Neuro-infection
Department of Cell Biology & InfectionSandrine Etienne-Manneville - Astrocytic responses to inflammatory situationsAstrocytes form the majority of glial cells of the central nervous system. They play a key role in brain homeostasis, they serve as physical and nutritional support for neurons and directly participate in synaptic transmission. In inflammatory situations, such as those...
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Article | 2021.08.03
Neurodegenerative Diseases
Department of Cell Biology & InfectionSandrine Etienne-Manneville - Astrocytic responses to inflammatory situationsAstrocytes form the majority of glial cells of the central nervous system. They play a key role in brain homeostasis, they serve as physical and nutritional support for neurons and they directly participate in synaptic transmission. In inflammatory situations, such as...
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Fiche maladie | 2021.07.22
Lyme disease (Lyme borreliosis)
Lyme disease, also known as Lyme borreliosis, is a tick-borne disease. It is the most widespread vector-borne disease in the entire northern hemisphere. Its incidence continues to rise at global level as a result of demographic and environmental factors, including climate change.
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News | 2021.07.19
AFROSCREEN, boosting variant surveillance in 13 African countries
The Agence française de développement (AFD) and ANRS | Maladies infectieuses émergentes, in partnership with the Institut Pasteur, IRD, and laboratories across 13 African countries, are launching the joint AFROSCREEN project. This project meets an urgent need for surveillance of the development of SARS-CoV-2 variants and other emerging pathogens by bolstering laboratory genomic sequencing...