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News | 2020.02.04
Transgenerational sterility caused by heritable small RNAs
The results of a study from researchers from Institut Pasteur illustrate how small non-coding RNAs can act as epigenetic molecules capable of transmitting traits across generation, over and above the information encoded in our genomes. Using the nematode Caenorhabditis elegans they show that the inheritance of small RNAs antisense to histone genes adversely affect the fertility of worms across...
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Document de presse | 2014.06.09
Immunological memory discovered in fetuses
Scientists from the Institut Pasteur in Paris, the Institut Pasteur of Shanghai and INSERM research unit 1041, "Immune Regulation and Vaccinology", in collaboration with the Paris Public Hospital Network, have recently demonstrated the existence of immunological memory cells in fetuses. These cells are developed in utero and are capable of producing an inflammatory-type immune response...
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News | 2021.07.15
BCG vaccine: the first tuberculosis vaccination took place a century ago
July 2021 marks the hundredth anniversary of the first vaccination of an infant with the BCG vaccine. Although tuberculosis is still one of the ten leading causes of mortality worldwide, this vaccine, developed at the Institut Pasteur, led to a steep reduction in the number of cases. We take a look back at how the vaccine was discovered.Albert Calmette arrived in Lille in 1897 as director of the...
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Article | 2016.11.10
The early years 1847-1862
In 1847 Louis Pasteur, a young chemist freshly graduated from the prestigious Ecole normale supérieure, set to work on the problem posed by German physicist Eilhard Mitscherlich, namely, why do sodium ammonium paratartrate and tartrate - two seemingly identical chemical substances - affect polarized light differently ?
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Document de presse | 2014.08.27
Potential strategies for limiting the hepatitis C epidemic in Egypt
In the fight against hepatitis C, directing preventive and curative interventions towards sufferers of chronic diseases requiring regular medical care would be an effective means of reducing transmission of the hepatitis C virus (HCV) in Egypt, and undoubtedly also in other countries with limited resources. This theory has arisen from a mathematical modeling study carried out as part of the ANRS...
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Document de presse | 2011.02.20
Unsuspected immune arsenal in infants
While completely protected from any infectious germs in their mother’s womb, fetuses spontaneously develop, “in advance”, an immune defense system ready to react to the bacterial colonization of their digestive tract at birth. This surprising observation made by scientists at the Institut Pasteur and the French National Center for Scientific Research (CNRS) also shows that this...
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Article | 2024.04.30
Federico Nitti, researcher and resistance fighter
Known for demonstrating the antibacterial activity of sulfonamides, the first antibiotics used, this Italian biologist and naturalized French citizen was a celebrated resistance fighter.
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Article | 2019.08.06
Vaccinology and Immunotherapy Initiative: Innovation – Vaccine Candidates
The Institut Pasteur has a distinguished history of vaccine development as a means to improve global health. A stronghold of the Institut Pasteur in vaccines is the development of novel technologies for vaccine design and delivery with several candidates currently under clinical evaluation, either licensed to development and commercialization partners or under Institut Pasteur sponsorship.
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News | 2023.01.06
Development of a pentavalent vaccine against New World arenaviruses
An Institut Pasteur team has successfully developed a pentavalent vaccine against the five pathogenic arenaviruses circulating in South America and tested it in a primate model. Each of the viruses has a low incidence but a very high mortality rate, so combining them in a single vaccine would help facilitate vaccine development and ensure that the population can be protected as soon as possible...
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Article | 2024.04.30
Edmond Nocard, discoverer of the Nocardia bacterium
Veterinarian and biologist, this disciple of Louis Pasteur pioneered the study of microbial animal diseases and is considered the founder of veterinary microbiology.