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News | 2019.10.02
Lassa fever: vaccine set to be trialed
There is currently no vaccine for the Lassa arenavirus, which causes Lassa fever. This hemorrhagic fever, endemic in West Africa, infects up to 300,000 people each year. Given the urgency of the situation, scientists in the Biology of Viral Emerging Infections Unit and the Viral Genomics and Vaccination Unit at the Institut Pasteur evaluated the efficacy of several vaccine candidates. Following...
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Document de presse | 2019.10.22
A blood factor involved in weight loss and aging
Aging is a process that affects all functions of the human body, particularly brain function. However, aging can be delayed through lifestyle changes (physical exercise, restricting calorie intake, etc.). Researchers at the Institut Pasteur and CNRS have elucidated the properties of a molecule in the blood – GDF11 – whose mechanisms were previously unknown. In a mouse model, they showed that this...
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Portrait | 2019.11.18
Lluis Quintana-Murci: discovering the world and humankind
Lluis Quintana-Murci is a scientist specializing in human genetics, with a particular focus on population genetics. His fascinating research tells an amazing story – our story, the story of humanity through time and in all its stunning diversity. Lluis was delighted to talk to us about his background and his passion for his work.Lluis was born in 1970 in Palma de Mallorca in Spain. As a child, he...
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News | 2020.04.22
Neurodevelopmental disorders: a daily practical guide by InovAND to help families deal with the difficulties of lockdown
Institut Pasteur partner InovAND, the Excellence Center in the Greater Paris region specializing in autism spectrum and neurodevelopmental disorders, is publishing a practical guide every day to help families overcome the difficulties associated with the lockdown.The lockdown soon proved to be a testing time for many families, especially those with a child affected by neurodevelopmental disorders...
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News | 2020.06.02
The hidden population of multidrug-resistant Klebsiella bacteria colonizing the human digestive tract
Klebsiella bacteria are responsible for some of the most antibiotic-resistant infections. A major study on intestinal colonization by Klebsiella has shed light on human carriage of these strains in the community (i.e. outside hospitals) in low-income countries. This study reveals that controlling Klebsiella carriage is a complex challenge.It is normal to find Klebsiella bacteria inhabiting the...
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News | 2020.12.02
Diphtheria: identification of a penicillin resistance gene
Before the vaccine era, diphtheria was the most deadly respiratory infection in young children. There are still outbreaks of diphtheria in some world regions and cases can occur among unvaccinated individuals, with severe consequences. Antibiotics are vital in treating diphtheria, and the emergence of antibiotic resistance is a major public health concern. A team of Institut Pasteur scientists...
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Document de presse | 2020.12.28
COVID-19: optimizing surveillance in long-term care facilities
Throughout the world, long-term care facilities have been high-risk sites for virus spread since the emergence of the COVID-19 epidemic. In this context, the capacity for timely surveillance and control of case numbers is essential in such facilities. Scientists at the Institut Pasteur have joined forces with the University of Versailles-Saint-Quentin-en-Yvelines, Inserm, and the National...
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News | 2021.03.30
Mobilization of the Institut Pasteur International Network to manage the COVID-19 outbreak: case study of support provided to the Institut Pasteur de Bangui
Since the beginning of the COVID-19 pandemic, and increasingly rapidly thereafter, the Institut Pasteur International Network has drawn heavily on all its expertise and resources to tackle this emerging virus and its consequences, particularly through its support of institutes based in low-income countries. All Network member institutes have been identified by their health authorities as...
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Document de presse | 2021.04.21
SARS-CoV-2: infection induces antibodies capable of killing infected cells regardless of disease severity
Drawing on epidemiological field studies and the FrenchCOVID hospital cohort coordinated by Inserm, teams from the Institut Pasteur, the CNRS and the Vaccine Research Institute (VRI, Inserm/University Paris-Est Créteil) studied the antibodies induced in individuals with asymptomatic or symptomatic SARS-CoV-2 infection. The scientists demonstrated that infection induces polyfunctional antibodies....
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Document de presse | 2022.04.14
Decoding a direct dialog between the gut microbiota and the brain
Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions. Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and adapt appetite and...