Isolating and characterizing the human antibodies that neutralize SARS-CoV-2

2019-NCOV THERAMAB project

Aimto elucidate the mechanisms behind the antibody responses to SARS-CoV-2 and investigate the role they may play in eliminating the virus in infected individuals. The idea is to improve our understanding of the antibody responses of anti-SARS-CoV-2 memory B lymphocytes at molecular and functional level (B lymphocytes are the immune cells that produce antibodies). The memory B cells that develop after an initial infection have a long life span and are capable of intervening rapidly and effectively in the event of reinfection. The project aims to harness the discoveries made to develop a treatment based on the use of human neutralizing antibodies (immunotherapy).  

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