Collection Nationale de Cultures de Microorganismes (CNCM)


Due to the gradual return to our activities during this exceptional period for COVID-19, the deadlines for deposits’ acceptance and sample requests may be extended.

May 25th 2020



Depositors should:

  1. complete the deposit documents,

  2. provide the microorganism as frozen material in form of 12 samples out of a single

preparation, each sample containing at least 106 viable units (lower titers may be accepted).

Furthermore, depositors are asked to supply the CNCM with any viable material which is not available at the CNCM1 and which is needed to propagate, to test and/or to store the microorganism. For the same purposes depositors are also asked to furnish any ingredient which is not free or is hard to access.

Steps to follow

La CNCM fournit les documents de dépôt appropriés, selon le type de microorganisme et répond, par écrit, à toutes les questions adressées par courrier ou par Email. Par ailleurs, elle est toujours prête à donner des compléments d'information et des conseils par téléphone dans les limites de ses compétences.

Preparing the Deposit

  • The depositor should ensure that he meets all the requirements as to the form and quantity of the biological material to be transmitted for the purposes of deposit of the microorganism and should fill in the documents and give all the information asked for.
  • The documents should be signed by the scientist responsible for the biological material and by an Official of the depositing organization.
  • Depositors must send to the CNCM by e-mail the deposit documents (form, addendum and contract) before the shipment of the biological material, so that the CNCM verifies that all the necessary information is given and that it is technically and legally able to accept the microorganism.
  • The CNCM communicates by e-mail, as soon as possible, its agreement, or disagreement, with the necessary questions, comments and recommendations.
  • The sending of the originals of the deposit documents, duly completed and signed, must precede or accompany the sending of the biological material.

Transfer of the biological material

  • Depositors are strongly advised to inform the CNCM when they plan to ship the biological material and to provide essential shipping information.

  • Depositors must comply with any safety requirement for the transport/export of the material, particularly they must comply with the specific requirements for the packaging and for the labeling according to the hazard group of the microorganism and of the refrigerant, (2) make sure that the package is accompanied by any documentation required by the relevant international and national Regulations concerning the transport and, where appropriate, the export of the material (export permit).

Registration of the microorganism

As soon as the microorganism is received in a condition which does not preclude for evident reasons its acceptance, the CNCM registers the biological material in the exercise book and promptly communicates in writing the registration number to the depositor. THE COMMUNICATION OF THE REGISTRATION NUMBER OF THE BIOLOGICAL MATERIAL DOES NOT IMPLY THAT THE CNCM IS STRICTLY OBLIGED TO ACCEPT THE MICROORGANISM.

Acceptance of the microorganism

The CNCM accepts the microorganism if

1. all the requirements are complied with,

2. and the examination of the content of at least one of the transmitted samples has provided confirmation that by no fact the CNCM is precluded from performing the tasks relating to the microorganism that it must perform under the Treaty.

The receipt referred to in Rule 7.1 of the Regulations under the Treaty testifies to the acceptance of the microorganism. The receipt is issued on the international form BP/4. If the microorganism is accepted, its accession number is identical to the registration number of the relevant biological material.

The average time of acceptance of a microorganism is 90 days.

The notification of the acceptance, or of the refusal, is issued within a six month time period after the date on which the depositor has complied with all the requirements concerning the deposit, except in some cases, where the growth of the microorganism is particularly slow, where the known conditions for propagation, tests and/or storage are not satisfactory, where some ingredients are difficult to access, or where irregularities or unexpected facts are noticed and need confirmation.

Validation of the deposit

Once all tests have been performed by the CNCM to be sure that it is in a position to comply with the requirements under the Treaty, the first viability statement referred to in Rule 10.2.a)i) is issued on the international form BP/9.

The first viability statement indicating a positive result testifies to the validity of the deposit. This statement is issued at the same time as the receipt.

Request for authenticity check

The CNCM prepares its own batches by subculturing original material at the time of deposit and, if need be, at any time during the period of the storage. Samples of those batches are sent to the depositor so that he can test them for all known properties and verify that these Properties are preserved under the conditions used by the CNCM for growth and storage.

Period of storage

The duration of storage of any microorganism deposited under the Treaty is of at least 30 years after the date of deposit and at least five years after the most recent request for a sample.

The depositor should be informed that the deposit cannot be cancelled during this period, neither by the depositor nor by the CNCM, regardless of the status of the applications involving the microorganism or the use of it.

The “fee for storage” is a single fee which includes tests and storage for the whole duration of the deposit. This fee is subject to Value Added Tax (VAT) according to French Law and must be paid after receipt of the relevant invoice.

Fees for deposit

Bacteria, Phages, Filamentous fungi, Yeasts                                                    701.27 €

Virus propagatesd on cell cultures                                                                    1 086.96 €

Cell cultures                                                                                                        1 448.27 €

Back to top