Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection

PPCOVi Project

Aim: The PDZ-binding motifs of two viral proteins play an important role in virus replication and pathogenesis of SARS-CoV. Through in vitro and cellular high-throughput assays, this project aims to identify the cellular PDZ-containing proteins targeted by these two viral proteins during infection and to characterize the mechanism whereby the viral sequences compete with cellular PBM-PDZ interactions.

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