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Document de presse | 2021.05.12
An Asthma Vaccine Effective in Mice
Inserm teams led by Laurent Reber (Infinity, Toulouse) and Pierre Bruhns (Humoral Immunity, Institut Pasteur, Paris) and French company NEOVACS have developed a vaccine that could induce long-term protection against allergic asthma, reducing the severity of its symptoms and thus significantly improving patient quality of life. Their research in animals has been published in the journal Nature...
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Document de presse | 2017.05.05
The migration history of Bantu-speaking people: genomics reveals the benefits of admixture and sheds new light on slave trade
During a wave of expansion that began 4,000 to 5,000 years ago, Bantu-speaking populations – today some 310 million people – gradually left their original homeland of West-Central Africa and traveled to the eastern and southern regions of the continent. Using data from a vast genomic analysis of more than 2,000 samples taken from individuals in 57 populations throughout Sub-Saharan Africa,...
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Document de presse | 2006.04.26
A breakthrough in the fight against multiresistance to antibiotics
Multiresistance to antibiotics is a major public health problem. In hospitals, multiresistant pathogens are the main obstacle hindering the control of nosocomial infections. One of the main ways of spreading such resistance is the transfer between bacteria of a class of particularly mobile elements, called integrons, which are carriers of these resistance factors. In a study published today ? in...
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Document de presse | 2005.09.05
Cholera: How Parasites Make Bacteria Pathogenic
Vibrio cholerae, the bacteria that causes cholera, is made pathogenic by one of its parasites, the CTX virus. This virus enables the vibrio to produce a toxin that causes the lethal diarrhea of cholera. Researchers at the CNRS and Institut Pasteur have recently proven, in a work published in Molecular Cell, which adaptive method the CTX bacteriophage uses to propagate itself so effectively in the...
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CNR/CCOMS | 2019.11.19
Emerging animal pathogens in humans
World Organization for Animal Health - Collaborating Center (WOAHCC) for the "detection and identification in humans of emerging animal pathogens and development of tools for their diagnoses".The Environment and Infectious Risks Unit, Laboratory for Urgent Response to Biological Threats, and Pathogen Discovery Laboratory host this WOAHCC.HeadsJean-Claude ManuguerraMarc EloitDetection and...
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Document de presse | 2009.07.19
How pathogens have shaped genes involved in our immune system
A recent study on human genetics on various populations across the world conducted by researchers from the Institut Pasteur and the CNRS has shown how pathogens can shape the patterns of genetic diversity of our immune system over time. Results show that bacteria, fungi and parasites, unlike viruses, appear to have allowed the introduction of mutations in the genes of some proteins of the innate...
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News | 2020.11.26
Presbycusis: ultra-rare genetic mutations responsible for a quarter of cases occurring around the age of 50
Presbycusis, or age-related hearing loss, involves genetic and environmental factors. A genomic analysis can identify gene variants whose pathogenicity subsequently needs to be confirmed. As a general rule, frequent variants have little or very little effect; it is their cumulative impact in several genes that explains the impairment. Ultra-rare variants, on the other hand, have a strong impact...
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Document de presse | 2024.10.15
Resistance mutations to nirsevimab are rare in respiratory syncytial virus (RSV)
Nirsevimab is an antibody targeting the respiratory syncytial virus (RSV). Available in France since September 2023, it is indicated in neonates and infants for the prevention of bronchiolitis caused by RSV. However, its widespread use raises the question of the emergence of resistance mutations. The POLYRES study, the largest prospective surveillance study of nirsevimab breakthrough infections...
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Document de presse | 2025.05.29
Revelations on the History of Leprosy in the Americas
Leprosy existed in America long before the arrival of Europeans: a new study reveals the history of a neglected pathogen.Long considered a disease brought to the Americas by European colonizers, leprosy may actually have a much older history on the American continent. Scientists from the Institut Pasteur, the CNRS, and the University of Colorado (USA), in collaboration with various institutions...
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News | 2022.11.10
ERC grants: new funding awarded in October 2022
Since they were launched in 2007, European Research Council (ERC) grants have become a mark of scientific excellence. Three new ERC Synergy Grants have recently been awarded for international projects involving scientists working on the Institut Pasteur campus.