Viruses

Teams of the Department of Virology, of Global Heath, of Structural Biology and Chemistry and of Computational Biology study viruses causing infections to understand their epidemiology and to develop alternative strategies to fight them and overcome drug resistance.

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Hervé Bouhry - Lyssavirus epidemiology and neuropathology, National Reference Centre for Rabies, WHO Collaborating Centre for reference and research on rabies

This project aims at developing a new protocol for rabies post exposure prophylaxis  (PEP) and a successful treatment, ultimately improving the probability of survival of patients who have not received adequate PEP and have possibly developed rabies symptoms.

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Olivier Gascuel - Evolutionary Bioinformatics Unit 

Phylogeny-, modelling-, and machine learning-based analyses of the emergence and diffusion of drug resistance mutations in HIV.

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Hugo Mouquet - Humoral Immunology Laboratory

This Group develops and characterizes monoclonal antibodies with antiviral potency.

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Michaela Müller-Trutwin (head) - HIV, Inflammation and Persistence Unit

The scientists search for host-directed therapies aiming to kill HIV-infected cells or durable control HIV infection in order to contribute to the development of a cure for HIV.

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Nadia Naffakh - Molecular Genetics of RNA Viruses Unit

This unit recently demonstrated the potential of synthetic molecules that destabilize the RED-SMU1 splicing complex as an antiviral, host-directed therapy which could be active against a wide range of influenza viruses and be less prone to drug resistance. 

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Félix Rey - Structural Virology Unit

The researchers study the tree-dimensional organization of virus particles and  viral replication enzymes, focusing on enveloped viruses and the envelope glycoproteins anchored in the viral membrane. One main emphasis in the unit is to understand the molecular mechanism involved in the merge of the viral envelope with the membrane of the cell for entry, as well the evolutionary links with proteins driving the fusion of eukaryotic cells, for instance the fusion of sperm and egg.

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Asier Saez-Cirion (team leader) - HIV, Inflammation and Persistence Unit

The scientists search for host-directed therapies aiming to kill HIV-infected cells or durable control HIV infection in order to contribute to the development of a cure for HIV.

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Olivier Schwartz - Virus And Immunity Unit

In collaboration with the laboratory humoral responses to pathogens, directed by Hugo Mouquet, the scientists study the effect of anti-HIV-1 broadly neutralizing antibodies (bNAbs) on HIV-1 spread. The unit focuses on effector functions of bNAbs, and their ability to eliminate  HIV-1 infected cells through ADCC (Antibody-Dependent Cellular Cytotoxixity) and other means

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Sylvie van der Werf - Molecular Genetics of RNA Viruses Unit

The unit focuses on the mechanisms of virus evolution and virus-host protein-protein interactions as well as the large collection of influenza and other respiratory viruses of the National Reference Center for Respiratory viruses. This provides a unique setting for the evaluation of the potential of emergence of antiviral resistance, identification of new antiviral targets with reduced potential for viral escape and assessment of the performance of new antiviral inhibitors.

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Marco Vignuzzi - Viral Populations and Pathogenesis Unit

This unit studies how viruses evolve and adapt to new environments; as such, the scientists identify the ways that viruses can evolve to escape antiviral approaches and develop ways to counter these measures through evolutionary concepts.

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