Scientists from twelve countries have recently joined forces to develop a program to identify new antimicrobial molecules. The project is based around the IRAADD, an international cooperation network of which the Institut Pasteur is a member.
Antimicrobial resistance remains a major public health issue with repercussions for several infectious diseases. Research on this issue is one of the Institut Pasteur's priority research areas, as laid down in its 2019-2023 Strategic Plan. Scientists from the Institut Pasteur recently contributed to a "roadmap" publication in the journal Nature Reviews Chemistry. The article provides a general overview of the current situation and proposes a research program to tackle the problem of antimicrobial resistance. The program is based around the IRAADD, the International Research Alliance for Antibiotic Discovery and Development, of which the Institut Pasteur is a member.
A network for translational science
IRAADD is an international network of scientists and industry partners that was set up to develop new antibiotic drug candidates. It has proposed a research plan to discover and develop molecules capable of overcoming the multidrug resistance witnessed in some infectious bacterial agents. To achieve these aims, the publication pleads the case for the development of translational science, which bridges the gap between basic research and industrial applications.
The roadmap emphasizes how important it is for skills, knowledge and individuals to be able to move freely between these two worlds. It also suggests that simpler legal frameworks are needed to manage the intellectual property of any new molecules developed as a result of complex collaborations between several organizations. Joining forces within a network is a way of raising awareness of the need for antibacterial drugs, finding sources of funding and communicating with decision-makers. The research paper, produced following a seminar attended by scientists and industry stakeholders, was signed by 54 authors from 12 different countries. The publication calls for further conferences and dedicated discussions to underpin these collaborations.
Towards the sustainable discovery and development of new antibiotics, Nature Reviews Chemistry, August 19, 2021
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