molecular mechanisms
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2021.05.21
Dominant optic atrophy (DOA) is one of the most common forms of mitochondrial disease. It can be caused by genetic mutations in OPA1 resulting in mitochondrial...
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2020.10.16
Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for which no treatment is available. X-ray structures of the hantavirus...
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2020.02.08
In nature, female mosquitoes take successive blood meals during which they are exposed to a variety of microbes present in the host. In Africa, Trypanosoma...
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2020.08.04
Resistance to artemisinin, the main component of current antimalarial treatments recommended by WHO, is widespread in South-East Asia, but has not been...
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2020.10.24
α1β2γ2 GABAA receptors mediate most inhibitory synaptic transmission in the brain, and are the target of widely used therapeutic drugs such as benzodiazepines...
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2021.02.22
The Lymphopoiesis Unit identified within the first cells that seed the thymus a unique population of lymphoid progenitors. These cells can generate lymphoid...
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2021.05.03
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Emerging and re-emerging viruses are key players among the different pathogens that have caused recent epidemics, as attested by several...
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2020.03.05
Cells in vivo organize into 3D structures that underlie the shape and mechanics of tissues, as well as their biological function. Researchers mapped how...
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2020.03.27
Replicative DNA polymerases have evolved the ability to copy the genome with high processivity and fidelity. In Eukarya and Archaea, their processivity is...
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2020.07.03
The ARIA software suite developed at Institut Pasteur automates the analysis of NMR data to calculate three-dimensional structures of macromolecules. To...