A SARS-CoV-2 genome sequencing technique to analyze low-quality clinical samples

SABSOS project

Aim: viral genomics is a key tool in the response to emerging disease outbreaks like that caused by SARS-CoV-2. But sequencing can be difficult because of poor quality samples or the low ratio of viral to host RNA. This technical project will implement and optimize an approach for processing clinical samples even if they are of poor quality and have a low viral load.

This method has worked for other RNA viruses (chikungunya using samples with a very low load; dengue virus using individual mosquitoes; degraded Zika virus samples).

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