Mechanisms of intercellular spreading of SARS-CoV-2: assessing the role of TNTs to escape immune surveillance and expand tropism and pathogenicity

COVID-Spreads project

Aim: We will study the mechanism of spreading of SARS-CoV-2 between permissive (eg; epithelial) and non-permissive (eg; neuronal) cells, and investigate the role of TNTs, as well as the dependence on the ACE2 receptor. Our cryoEM and FIBSEM set up, will provide unique structural information about this process. Overall, this project will allow understanding the mechanism of the viral neurotropism, as well explain its immune evasion capacity.

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