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Aim: The high case fatality ratio of Covid-19 compared to the flu is a global preoccupation. It could be related to non-reporting of mild and asymptomatic infection whose role in transmission is not completely clear if not diagnosed. It is therefore of paramount importance to quickly evaluate the true extent of the infection of SARS-CoV-2. We planned it in different population groups (close contacts of confirmed Covid-19, Health care workers (HCW), Travellers from high risk countries, merchants of bushmeat, and blood donors) in Cameroon.