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Report | 2017.07.24
AIDS: progress and fresh hope
Having claimed the lives of close to 40 million people (source: OMS 2017) since HIV was discovered in 1983, AIDS is indeed a global health catastrophe. Significant progress has nevertheless been made over the last few years, particularly in developed countries, with longer life expectancy for patients on triple therapy. But this treatment does not eliminate the virus and must be taken for life....
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Article | 2020.06.16
Working towards controlled detection of SARS-CoV-2 by the innate immune system
Aim: controlling the SARS-CoV-2 outbreak requires both scientific knowledge and antiviral drugs. RIG-I-like receptors in the cell cytoplasm play a major role in detecting infection with RNA viruses and in initiating and modulating antiviral immunity. The aim of the project is to study the RNA ligands in the SARS-CoV-2 virus that are detected by these receptors. The project will shed light on...
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Article | 2020.07.07
Modeling human SARS-CoV-2 infection in mice with human lung xenografts
To date there is no specific therapeutic treatment or vaccine for COVID-19 caused by the SARS-CoV-2 virus and relevant animal models that mimic human COVID-19 pathologies are lacking. We will generate two novel humanized mouse models: HuLung mice (human lung) and HIS-HuLung mice (and human immune system and human lung). Infection of HuLung and HIS-HuLung mice with SARS-CoV-2 will provide an in...
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Document de presse | 2023.06.06
Monkeypox: characterization of post-infectious immune response
In 2022-2023, an outbreak of monkeypox, now known as mpox (caused by the monkeypox virus or MPXV) led to 87,000 human cases in 170 countries[1]. Most cases were reported outside the usual areas in which the virus circulates. Since the outbreak began, surveillance of the virus has been stepped up in Europe, with nearly 5,000 cases being reported in France[2]. Scientists and clinicians from the...
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Report | 2024.03.12
COVID-19: which monoclonal antibodies should be used for vulnerable individuals?
Vaccination does not offer sufficient protection against severe forms of COVID-19 for people with a weakened immune system. For these individuals, monoclonal antibodies have long been the preferred therapeutic solution. But depending on the SARS-CoV-2 variant, the effectiveness of these treatments has fluctuated. Scientists have had to develop novel antibodies that are more effective while also...
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Article | 2025.08.19
Infectious Threats - Pasteur 2030
Infectious diseases and antibiotic resistance constitute one of the greatest global health threats. Institut Pasteur mobilizes its scientific resources and global network to anticipate and counter these risks.
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Article | 2018.01.30
A program concerning the Hand-Foot-And-Mouth disease in South East Asia
The infection called "hand, foot and mouth" (HFMD) is a viral disease that mainly affects children under 5 years. It is transmitted by direct contact between infected children and is characterized by fever, mouth sores and blisters on the hands, feet and buttocks. To date, there is no specific treatment for this disease. A global approach is being developed in Southeast Asia to define...
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Article | 2020.10.05
DEVELOPMENT OF INNOVATION
Development Of InnovationMichel Perez,Head of OfficeThe Development of Innovation Office works with researchers to develop their inventions throughout the acceleration and maturation phases by bringing industrial development skills and helping in attracting specific external funding.This office is composed of scientists with strong background in industrial research and development.The...
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Article | 2024.04.30
Hélène Sparrow: microbe hunter
A Polish-born French physician and biologist, Hélène Sparrow lived through wars and revolution, moving between soldiers’ bedsides and her research laboratory.
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Article | 2016.11.10
The final years 1877-1887
Between the age of 55 and 65 Louis Pasteur developed microbiology, applying it to medicine and surgery. Having established that diseases were caused by microorganisms, he then sought to identify and find a means of fighting them. His finest accomplishment was rabies.