These strategic resources are coordinated by the Technology and Scientific Programs Department (DTPS) through two Centers: the Center for Technological Resources and Research (C2RT) and the Center for Animal Resources and Research (C2RA).
To maintain its position at the forefront of science, the Institut Pasteur has set priorities for state-of-the-art technological development that will enable us to:
- perform imaging of living systems, from molecules to organisms;
- explore the metabolome, a new frontier in understanding biological systems;
- expand our capacities for single-cell analysis;
- provide an environment for the comprehensive study of vector-borne diseases;
- identify novel diagnostic and therapeutic approaches;
- enhance data management and collaboration at global level.
These priorities include
- Expanding our nanoimaging initiative by acquiring additional electron microscopes to optimize our use of the Titan KriosTM for atomic resolution in vitro or in cellulo protein imaging.
- Developing optical imaging methods for the multi-scale study of host-pathogen interactions: light sheet fluorescence microscopy, planar/cross-sectional imaging microscopy, magnetic resonance imaging, super-resolution microscopy, etc.
- Optimizing our crystallography, nuclear magnetic resonance (NMR), hydrogen exchange mass spectrometry and biophysics facilities to strengthen our expertise in structural biology.
- Setting up a metabolomics platform and/ or research unit to provide a shared infrastructure and pool our expertise in sample preparation and analysis using mass spectrometry and NMR.
- Developing new single-cell analysis pipelines for transcriptomes, proteomes, metabolomes and other components of the host and microbes.
- Establishing a new infrastructure for simultaneous analysis of the host, the vector and the pathogen under biosafety level 3 containment conditions (animal facility, insectarium, imaging capabilities).
- Boosting our ability to identify novel diagnostic and therapeutic solutions: high-content imaging, organ-on-a-chip, microfluidics, miniaturization, point-of-care testing, etc.
- Developing high-throughput approaches for antibody identification and production.
- Enhancing our data analysis and artificial intelligence capabilities by developing an effective strategy, recruiting research teams and fostering cooperation with external partners.
- Developing image analysis capabilities for complex samples so as to provide network maps at single-cell resolution.
- Implementing shared electronic data collection and analysis methods (Electronic Lab Notebooks (ELNs) and Laboratory Information Management Systems (LIMS)).
- Boosting internal resources for computing, storage and networking, and develop partnerships with cloud solution providers.