Coronavirus SARS-CoV-2 : the Institut Pasteur mobilization

The Institut Pasteur in Paris and its International Network of 32 institutes have been extremely active worldwide in responding with science to the pandemic caused by the SARS-CoV-2 coronavirus. Its response currently involves hundreds of people at the Institut Pasteur in Paris and several teams in the network in other countries. A coronavirus task force was set up by the Institut Pasteur in January to launch and coordinate new COVID-19 research by its teams. Many projects are also being carried out in partnerships or with the support of other organizations. Here are the research projects now under way, several others are set to begin shortly. Here is an inventory of the current research projects (as of May 29, 2020).

 

Research Projects

 Knowledge of the virus and its pathogenesis

SARS-CoV-2 fusion, replication and host responses (CoronaFusion project)

Covid-19 - Projets de recherche - Institut Pasteur

Evolution of SARS-CoV-2 and the antibody immune response in humans during infection (SARS-CoV-2_EVOLSERO project)

task force SARS-CoV-2

Monitoring the origins and transmission/spread of SARS-CoV-2 in Laos and Vietnam: searching for SARS-like viruses and detecting antibodies in vertebrates (SPILLOVER-CORONA project)

A technique to identify key cellular factors for SARS-CoV-2 infection (CoV-CRISPR project)

Profiling SARS-CoV-2 intra-viral and virus-host interactions on the basis of innate immunity signaling (PSII project)

Working towards controlled detection of SARS-CoV-2 by the innate immune system (CoV-2Sensing project)

Origins, natural reservoirs and interspecies transmission of SARS-CoV-2 and other SARS-like coronaviruses (ONRITS project)

Task Force Coronavirus - Institut Pasteur 2020

A combination of cutting-edge proteomic approaches for improving understanding of SARS-CoV-2 infection mechanisms (PROTEO-SARS-CoV-2 project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Paris, KKU | Characterization of variable systemic and mucosal immunity during SARS-CoV-2 infection and recovery (COVar_Immune project)

Development of research tools

Task Force Coronavirus - Institut Pasteur 2020

Characterization of interaction between SARS-CoV-2 Nsp3 protein and non-canonical nucleic acid structures (G4) present in infected cells (G4-COVID19 project)

Task force SARS-CoV-2 - Institut Pasteur

Development of cell lines for research (FlipSARS project) 

A SARS-CoV-2 genome sequencing technique to analyze low-quality clinical samples (SABSOS project)

Development of a test to identify inhibitors of SARS-CoV-2 proteases (Cov2-PIs project)

Task force SARS-CoV-2 - Institut Pasteur

Generation of animal models sensitive to SARS-CoV-2 to test vaccines or drugs (hACE2-COV project)

task force SARS-CoV-2

Production of recombinant antigens from two SARS-CoV-2 proteins and generation of nano-antibodies against these proteins for diagnostic and therapeutic applications (CORONABODIES project) 

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Paris, Dakar, Cameroon, Ivory Coast | Serological surveillance of SARS-CoV-2 and seasonal coronaviruses (CoronaSeroSurv project)

Task force SARS-CoV-2 - Institut Pasteur

The use of Artificial Intelligence Methods to Discriminate Covid-19 from other Community Acquired Pneumopathy using Chest X-Ray and CT images (AIMDP COVID-19 project)

Epidemiological research, social epidemiology

Building a collection of human biological samples in France (CORSER project – A seroepidemiological study of the SARS-CoV-2 virus)

Task force SARS-CoV-2 - Institut Pasteur

Red Cross health workers and volunteers and continuity of care with COVID-19: an operational approach using mixed methods (RCCOVID project)

Task force SARS-CoV-2 - Institut Pasteur

The Institut Pasteur studies the transmission of SARS-CoV-2 from humans to pets 

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | São Paolo | Descriptive study: epidemiological, clinical and immunological analysis of SARS-CoV-2 cases in the Metropolitan Region of São Paulo, Brazil (MRSP study)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | French Guiana, New Caledonia, Guadeloupe | Household transmission investigation study for SARS in overseas territories (EPICOVID-19 Project)

Task force SARS-CoV-2 - Institut Pasteur

Covid-19 risk evaluation among the household contacts of the first cases in Africa (COVID-19 risk evaluation project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL / Dakar / Evaluation of clinical presentation and evolution of SARS -CoV-2 coronavirus infection in Senegal (SEN-CoV project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL / Niger, Dakar, Cameroun, Madagascar / Protocol for assessment of potential risk factors for 2019-novel coronavirus (2019-nCoV) infection among health care workers in a health care setting. (Healthcare workers Africa project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Montevideo | Engineering an ACE2 derived polypeptide for label-free, real-time detection on a smartphone device and therapeutic intervention (isCoVDe – in silico Coronaviruses Decoy project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Cameroon, Paris | Evaluation of SARS-CoV-2 infection spread in various populations groups in Cameroon (infection spread in Cameroon project)

Development of diagnostic tools

Development of simple COVID-19 serological tools and targeted serosurvey of at-risk individuals (COVID-19 Serosurvey project).

Antibody profiling in recovering patients and development of a serological test for an epidemiological survey in individuals exposed to SARS-CoV-2 (SARS-CoV-2-LIPS project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | São Paolo | Developing a low-cost lab-on-a-chip for diagnosing SARS-CoV-2 (LAMP project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL / Canada / Developing a rapid diagnostic test to detect SARS-CoV2 virus in various environment (POC Project)

Prophylaxis and vaccine candidates

Development of an animal model and accelerated development of a DNA vaccine candidate (SCARD SARS-CoV-2 project)

task force SARS-CoV-2

Spike glycoprotein, lentiviral vectors and B/T-cell vaccine (VAC-NAB-COV project)

CEPI collaborates with the Institut Pasteur in a consortium to develop Covid-19 vaccine​.

Task force SARS-CoV-2 - Institut Pasteur

Randomized trial of Covid-19 chemoprophylaxis in healthcare professionals (COVIDAXIS trial)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Bulgaria |Development of novel nano-based multi-epitope vaccine against coronavirus SARS-CoV-2 - Generation of Humanized NSG transfer mouse model for vaccine testing (VacciNanoCor project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Madagascar | Investigation of the first cases of coronavirus (COVID-19) infections and their contacts in Antananarivo, Madagascar (Covid-19 & contacts Madagascar project)

Therapeutic research

Task Force Coronavirus - Institut Pasteur 2020

Isolating and characterizing the human antibodies that neutralize SARS-CoV-2 (2019-NCOV THERAMAB project)

Defective viral genomes (DVGs), potential antiviral inhibitors of SARS-CoV-2 (SARS-DVGs project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Roma, Paris, Lille |  Find potent antiviral drugs against SARS-CoV2 by targeting well identified proteins essential to the viral cycle. (DrugDesign_SARS2 project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Shanghai, Paris | Identification and isolation of potent human neutralizing antibodies against SARS-CoV-2 (NABCOV project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | Paris | Accelerating the identification & design of SARS-CoV2 antiviral drugs in combination with the “DrugDesign_SARS2” project (inSilico_Drugs_to_Beat_SARS2 project)

Task force SARS-CoV-2 - Institut Pasteur

INTERNATIONAL | INRS Canada | Urgent Discovery of Drug Candidates That Target Coronavirus SARS-CoV-2 (DrugCandidates-SARS-CoV-2 project)

Modeling

Task force SARS-CoV-2 - Institut Pasteur

Launch of a large-scale survey of the French citizens, about their contacts during containment (SOCIALCOV project)

Task force SARS-CoV-2 - Institut Pasteur

Covid-19: estimating the burden of SARS-CoV-2 in France

Bioinformatics

Task force SARS-CoV-2 - Institut Pasteur

COVID-19 - The Bioinformatics and Biostatistics Hub on the front line (GISAID, nextrain)

 

 

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